Novel nitrogen-enriched oridonin analogues with thiazole-fused A-ring: protecting group-free synthesis, enhanced anticancer profile, and improved aqueous solubility
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Oridonin, a Promising ent-Kaurane Diterpenoid Lead CompoundMolecular Insight in the Multifunctional Effects of OridoninDiscovery and development of natural product oridonin-inspired anticancer agentsChemical Composition and In Vitro Cytotoxicity of Essential Oils from Leaves and Flowers of Callistemon citrinus from Western HimalayasNovel hybrids of natural oridonin-bearing nitrogen mustards as potential anticancer drug candidatesent-Kaurane-based regio- and stereoselective inverse electron demand hetero-Diels-Alder reactions: synthesis of dihydropyran-fused diterpenoidsBiochemical and pharmacological characterizations of ESI-09 based EPAC inhibitors: defining the ESI-09 "therapeutic window".Oridonin inhibits hepatic stellate cell proliferation and fibrogenesis.Overcoming synthetic challenges of oridonin A-ring structural diversification: regio- and stereoselective installation of azides and 1,2,3-triazoles at the C-1, C-2, or C-3 position.The enantioselective construction of tetracyclic diterpene skeletons with Friedel-Crafts alkylation and palladium-catalyzed cycloalkenylation reactions.Evolution in medicinal chemistry of ursolic acid derivatives as anticancer agentsFormulation and evaluation of biodegradable nanoparticles for the oral delivery of fenretinide.Enhanced effects of novel oridonin analog CYD0682 for hepatic fibrosis.Structure-Activity Relationship Studies of Substituted 2-(Isoxazol-3-yl)-2-oxo-N'-phenyl-acetohydrazonoyl Cyanide Analogues: Identification of Potent Exchange Proteins Directly Activated by cAMP (EPAC) Antagonists.Oridonin ring A-based diverse constructions of enone functionality: identification of novel dienone analogues effective for highly aggressive breast cancer by inducing apoptosis.Targeting XBP1-mediated β-catenin expression associated with bladder cancer with newly synthetic Oridonin analogues.Induction of the mitochondria-mediated apoptosis in human esophageal cancer cells by DS2, a newly synthetic diterpenoid analog, is regulated by Bax and caused by generation of reactive oxygen species.Targeting 3-phosphoinositide-dependent protein kinase 1 associated with drug-resistant renal cell carcinoma using new oridonin analogsEnhanced anti-fibrogenic effects of novel oridonin derivative CYD0692 in hepatic stellate cells.Lasiokaurin derivatives: synthesis, antimicrobial and antitumor biological evaluation, and apoptosis-inducing effects.N-Propargylamines: versatile building blocks in the construction of thiazole cores.Natural product analogues: towards a blueprint for analogue-focused synthesis.Oridonin-loaded and GPC1-targeted gold nanoparticles for multimodal imaging and therapy in pancreatic cancer
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P2860
Novel nitrogen-enriched oridonin analogues with thiazole-fused A-ring: protecting group-free synthesis, enhanced anticancer profile, and improved aqueous solubility
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 19 June 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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Novel nitrogen-enriched oridon ...... nd improved aqueous solubility
@en
Novel nitrogen-enriched oridon ...... d improved aqueous solubility.
@nl
type
label
Novel nitrogen-enriched oridon ...... nd improved aqueous solubility
@en
Novel nitrogen-enriched oridon ...... d improved aqueous solubility.
@nl
prefLabel
Novel nitrogen-enriched oridon ...... nd improved aqueous solubility
@en
Novel nitrogen-enriched oridon ...... d improved aqueous solubility.
@nl
P2093
P2860
P356
P1476
Novel nitrogen-enriched oridon ...... nd improved aqueous solubility
@en
P2093
Christopher Wild
Chunyong Ding
Haijun Chen
Huiling Liu
Yusong Zhang
Zhengduo Yang
P2860
P304
P356
10.1021/JM400367N
P407
P50
P577
2013-06-19T00:00:00Z