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Genetic architecture of complex traits: large phenotypic effects and pervasive epistasis

Genetic architecture of complex traits: large phenotypic effects and pervasive epistasis

http://www.wikidata.org/entity/Q37018913

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Multi-omic data integration and analysis using systems genomics approaches: methods and applications in animal production, health and welfare Obesity genetics in mouse and human: back and forth, and back again Epistasis and quantitative traits: using model organisms to study gene-gene interactions Maternal nutrition induces pervasive gene expression changes but no detectable DNA methylation differences in the liver of adult offspring Deep congenic analysis identifies many strong, context-dependent QTLs, one of which, Slc35b4, regulates obesity and glucose homeostasis Generational association studies of dopaminergic genes in reward deficiency syndrome (RDS) subjects: selecting appropriate phenotypes for reward dependence behaviors The mystery of missing heritability: Genetic interactions create phantom heritability Evolving hard problems: Generating human genetics datasets with a complex etiology New approaches to disease mapping in admixed populations Identification of genes and networks driving cardiovascular and metabolic phenotypes in a mouse F2 intercross Genetic architecture of growth traits revealed by global epistatic interactions Network biology concepts in complex disease comorbidities Missing heritability and strategies for finding the underlying causes of complex disease Mouse genomic variation and its effect on phenotypes and gene regulation The Hybrid Mouse Diversity Panel: a resource for systems genetics analyses of metabolic and cardiovascular traits.Genomic survey of prepulse inhibition in mouse chromosome substitution strains.Inheritance patterns of progressive hearing loss in laboratory strains of mice Systems mapping: how to improve the genetic mapping of complex traits through design principles of biological systems.Interaction-based feature selection and classification for high-dimensional biological data Knowledge-driven multi-locus analysis reveals gene-gene interactions influencing HDL cholesterol level in two independent EMR-linked biobanks.The role of genetic variation in the causation of mental illness: an evolution-informed framework.Failure to replicate a genetic association may provide important clues about genetic architecture A genome-wide library of CB4856/N2 introgression lines of Caenorhabditis elegans.C57BL/6J mice as a polygenic developmental model of diet-induced obesity.Genotype and expression analysis of two inbred mouse strains and two derived congenic strains suggest that most gene expression is trans regulated and sensitive to genetic background.Effect of chromosome substitution on intrinsic exercise capacity in mice.Epistasis: obstacle or advantage for mapping complex traits?Transgenerational genetic effects of the paternal Y chromosome on daughters' phenotypes.Epistatic Networks Jointly Influence Phenotypes Related to Metabolic Disease and Gene Expression in Diversity Outbred Mice.Estimating directional epistasis Taste solution consumption by FHH-Chr nBN consomic rats.Extracting quantitative genetic interaction phenotypes from matrix combinatorial RNAi.A comparative assessment of mandible shape in a consomic strain panel of the house mouse (Mus musculus)--implications for epistasis and evolvability of quantitative traits.X-autosome incompatibilities in Drosophila melanogaster: tests of Haldane's rule and geographic patterns within species Identification of novel carcinogen-mediated mammary tumor susceptibility loci in the rat using the chromosome substitution technique.Body fat distribution and organ weights of 14 common strains and a 22-strain consomic panel of rats Ancestral paternal genotype controls body weight and food intake for multiple generations Modifier genes and the plasticity of genetic networks in mice.Genetic divergence and the genetic architecture of complex traits in chromosome substitution strains of mice.Genetic control of obesity and gut microbiota composition in response to high-fat, high-sucrose diet in mice.

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Genetic architecture of complex traits: large phenotypic effects and pervasive epistasis

http://www.wikidata.org/entity/Q37018913

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article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 09 December 2008

@en

vedecký článok

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vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

Genetic architecture of complex traits: large phenotypic effects and pervasive epistasis

@en

Genetic architecture of complex traits: large phenotypic effects and pervasive epistasis.

@nl

type

label

Genetic architecture of complex traits: large phenotypic effects and pervasive epistasis

@en

Genetic architecture of complex traits: large phenotypic effects and pervasive epistasis.

@nl

prefLabel

Genetic architecture of complex traits: large phenotypic effects and pervasive epistasis

@en

Genetic architecture of complex traits: large phenotypic effects and pervasive epistasis.

@nl

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PNAS.0810388105

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Proceedings of the National Academy of Sciences of the United States of America

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Genetic architecture of complex traits: large phenotypic effects and pervasive epistasis

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Andrew Kirby

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Annie E Hill

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David S Sinasac

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E J Kulbokas

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Haifeng Shao

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Hayden-William Courtland

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Joseph H Nadeau

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Karl J Jepsen

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Lindsay C Burrage

http://www.w3.org/2001/XMLSchema#string

Sheila R Ernest

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P2860

Data and theory point to mainly additive genetic variance for complex traits

Identification of ten loci associated with height highlights new biological pathways in human growth

Many sequence variants affecting diversity of adult human height

Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results

Genome-wide association analysis identifies 20 loci that influence adult height

A HapMap harvest of insights into the genetics of common disease

R/qtl: QTL mapping in experimental crosses

Genetic basis of proteome variation in yeast.

The landscape of genetic complexity across 5,700 gene expression traits in yeast

Analysing complex genetic traits with chromosome substitution strains.

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19910-19914

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scholarly article

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10.1073/PNAS.0810388105

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50

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105

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Mark Joseph Daly

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2008-12-09T00:00:00Z

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23641584

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19066216

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2604967

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