Deletion of Trpm7 disrupts embryonic development and thymopoiesis without altering Mg2+ homeostasis
about
The TRPM7 chanzyme is cleaved to release a chromatin-modifying kinaseMammalian MagT1 and TUSC3 are required for cellular magnesium uptake and vertebrate embryonic developmentSecond messenger role for Mg2+ revealed by human T-cell immunodeficiencyTRP channels in neurogastroenterology: opportunities for therapeutic interventionInternational Union of Basic and Clinical Pharmacology. LXXVI. Current progress in the mammalian TRP ion channel familyTransient receptor potential (TRP) channels and cardiac fibrosisTRPM7 and its role in neurodegenerative diseasesRegulation of transient receptor potential channels by the phospholipase C pathwayIon channels and transporters in lymphocyte function and immunityCurrent understanding of TRPM7 pharmacology and drug development for strokePermeation, regulation and control of expression of TRP channels by trace metal ionsEmerging roles of L-type voltage-gated and other calcium channels in T lymphocytesDefects in TRPM7 channel function deregulate thrombopoiesis through altered cellular Mg(2+) homeostasis and cytoskeletal architecture.Magnesium excretion in C. elegans requires the activity of the GTL-2 TRPM channelTRPM channels and magnesium in early embryonic developmentTransient receptor potential channels as therapeutic targetsGenetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarizationEpithelial magnesium transport by TRPM6 is essential for prenatal development and adult survivalTRPM7Cleavage of TRPM7 releases the kinase domain from the ion channel and regulates its participation in Fas-induced apoptosis.TRPM7 regulates polarized cell movements.Abnormal differentiation of dopaminergic neurons in zebrafish trpm7 mutant larvae impairs development of the motor pattern.TRPM1 forms ion channels associated with melanin content in melanocytes.Aberrant over-expression of TRPM7 ion channels in pancreatic cancer: required for cancer cell invasion and implicated in tumor growth and metastasisDrosophila TRPM channel is essential for the control of extracellular magnesium levels.Blockade of TRPM7 channel activity and cell death by inhibitors of 5-lipoxygenase.TRPM7 activates m-calpain by stress-dependent stimulation of p38 MAPK and c-Jun N-terminal kinase.Zinc-induced neurotoxicity mediated by transient receptor potential melastatin 7 channels.The association between single-nucleotide polymorphisms of TRPM7 gene and breast cancer in Han Population of Northeast China.Role of TRPM7 in Cancer: Potential as Molecular Biomarker and Therapeutic Target.Calcium signaling in immune cells.Inactivation of TRPM7 kinase activity does not impair its channel function in mice.Newly developed Mg2+-selective fluorescent probe enables visualization of Mg2+ dynamics in mitochondria.TRPM7-mediated Ca2+ signals confer fibrogenesis in human atrial fibrillation.Cellular functions of transient receptor potential channels.Waixenicin A inhibits cell proliferation through magnesium-dependent block of transient receptor potential melastatin 7 (TRPM7) channelsFlow shear stress enhances intracellular Ca2+ signaling in pulmonary artery smooth muscle cells from patients with pulmonary arterial hypertension.Inhibition of TRPM7 channels reduces degranulation and release of cytokines in rat bone marrow-derived mast cellsMagnesium and embryonic development.KCa3.1 and TRPM7 channels at the uropod regulate migration of activated human T cells.
P2860
Q24298123-BD8ECA45-6AF7-49F9-9F77-A5ED80ED7763Q24311085-D1A1D57C-3570-4C9D-B1C1-7FE084046405Q24613811-732351A8-16B9-49D9-95B1-5B07BF7FAEF9Q24618774-265E5E80-4EB4-4620-8E8D-CEF3C6A96134Q24623493-21733562-6A44-4BC0-BC63-F2FF0B22C6B3Q24625500-FEF65620-B73A-4A3A-BDDE-AAEE3F26A511Q26798376-96E4A96E-2608-4AE2-9906-9BEDCE51C3A5Q26822505-B29B7D03-4410-460B-9E25-0CF56A56E993Q26829714-FB06E0AE-CB3A-4DE5-BB64-EF0CDE6D700AQ26853706-2F294CFE-C142-4796-9CDE-97B7E92D347CQ26999694-A29E322F-F971-469F-9671-4366B3F98E6DQ27000395-9F15BB8D-352A-48FC-8446-23CB11EB4983Q27322516-B02CABDC-614C-4994-AC71-C0C507D7B9B3Q27333276-CB35880C-AA3D-484A-B82A-94476C7D11F5Q27348770-7F337014-D9F1-4364-94DD-29B5D0886378Q28244558-C60B522C-DEFD-4A5B-8A6D-B9F86B258CD1Q28654771-EBEC7779-13C1-4803-BF29-BD53C8CA0E95Q28817847-9D94F5C0-AC1D-499A-8E1D-97CAE3D64FF0Q30361651-0CB8B7C8-0546-40BC-871C-65284A345032Q30520617-D1A976CA-9541-4629-B5FE-EB223F8EBF5EQ30528668-2A193FF9-D550-4272-9CAF-60E287E06FACQ30575217-AD5C1F04-1D95-4EC1-9282-AC0474846FF5Q30583204-5552C391-5B2E-417A-A58B-2B5AC686381BQ30640734-F1F83275-22BF-4B8D-90B3-7C55DD976A4FQ30982539-905F1CF8-302B-45BC-A63E-FC2E9C82CE06Q33612288-4BF9ABF0-2A2A-4332-A000-369D867A5148Q33671527-696791B3-B2E6-4608-83A4-ABE374A9A28FQ33748122-8BD02C9C-A29D-41AA-98A7-E85101759CCCQ33839298-501CF77F-ACF0-4B95-8097-F2EB690AA922Q33851509-7F379284-604D-465C-8C31-CFD3C3DE1CB6Q33878792-236F190A-76E5-4BDC-B8B4-C642E6EAD157Q33912584-32014A46-4007-4548-998D-01F5BE1EAAB8Q33999997-C3410A0A-6861-41BA-97BD-D85A36EB2A34Q34008101-8960EC2A-D9FE-4D1F-93FE-0A41365F48E6Q34020976-B7B22AA2-A043-4AF1-9B4D-586FC92D5F34Q34021556-9641112C-229E-4D3B-BDEA-417B707E7008Q34062874-A0798F01-F4BC-4B14-955F-E1D91E114A0EQ34072299-7D5E5728-99B6-4099-BADF-1FBCC3754C8DQ34392661-D8A995F6-FC40-460C-BD63-E414C7F737EEQ34405737-202618C4-A09D-4FAD-9DE4-34B49DD7959F
P2860
Deletion of Trpm7 disrupts embryonic development and thymopoiesis without altering Mg2+ homeostasis
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on October 2008
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Deletion of Trpm7 disrupts emb ...... hout altering Mg2+ homeostasis
@en
Deletion of Trpm7 disrupts emb ...... out altering Mg2+ homeostasis.
@nl
type
label
Deletion of Trpm7 disrupts emb ...... hout altering Mg2+ homeostasis
@en
Deletion of Trpm7 disrupts emb ...... out altering Mg2+ homeostasis.
@nl
prefLabel
Deletion of Trpm7 disrupts emb ...... hout altering Mg2+ homeostasis
@en
Deletion of Trpm7 disrupts emb ...... out altering Mg2+ homeostasis.
@nl
P2860
P50
P356
P1433
P1476
Deletion of Trpm7 disrupts emb ...... hout altering Mg2+ homeostasis
@en
P2093
Adriana Donovan
P2860
P304
P356
10.1126/SCIENCE.1163493
P407
P577
2008-10-01T00:00:00Z