WRN protects against topo I but not topo II inhibitors by preventing DNA break formation
about
Roles of Werner syndrome protein in protection of genome integrityRecapitulation of Werner syndrome sensitivity to camptothecin by limited knockdown of the WRN helicase/exonucleaseAssociation of epigenetic inactivation of the WRN gene with anticancer drug sensitivity in cervical cancer cellsThe Drosophila Werner exonuclease participates in an exonuclease-independent response to replication stress.Human RecQ helicases in DNA repair, recombination, and replication.Serines 440 and 467 in the Werner syndrome protein are phosphorylated by DNA-PK and affects its dynamics in response to DNA double strand breaksThe 19S proteasome subunit Rpn7 stabilizes DNA damage foci upon genotoxic insult.The Drosophila orthologue of progeroid human WRN exonuclease, DmWRNexo, cleaves replication substrates but is inhibited by uracil or abasic sites : analysis of DmWRNexo activity in vitro.Copy number changes at 8p11-12 predict adverse clinical outcome and chemo- and radiotherapy response in breast cancer.
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P2860
WRN protects against topo I but not topo II inhibitors by preventing DNA break formation
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 15 October 2008
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
WRN protects against topo I but not topo II inhibitors by preventing DNA break formation
@en
WRN protects against topo I but not topo II inhibitors by preventing DNA break formation.
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type
label
WRN protects against topo I but not topo II inhibitors by preventing DNA break formation
@en
WRN protects against topo I but not topo II inhibitors by preventing DNA break formation.
@nl
prefLabel
WRN protects against topo I but not topo II inhibitors by preventing DNA break formation
@en
WRN protects against topo I but not topo II inhibitors by preventing DNA break formation.
@nl
P2093
P2860
P1433
P1476
WRN protects against topo I but not topo II inhibitors by preventing DNA break formation
@en
P2093
Bernd Kaina
Christopher Gestrich
Maja T Tomicic
Markus Christmann
Vilhelm A Bohr
P2860
P304
P356
10.1016/J.DNAREP.2008.08.008
P577
2008-10-15T00:00:00Z