Molecular signatures in skin associated with clinical improvement during mycophenolate treatment in systemic sclerosis
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Gene expression profiling offers insights into the role of innate immune signaling in SScRecent advances in the genetics of systemic sclerosis: toward biological and clinical significanceDissecting the heterogeneity of skin gene expression patterns in systemic sclerosisMolecular stratification and precision medicine in systemic sclerosis from genomic and proteomic data.Adiponectin is an endogenous anti-fibrotic mediator and therapeutic target.Limited cutaneous systemic sclerosis skin demonstrates distinct molecular subsets separated by a cardiovascular development gene expression signatureHigh Rhodotorula sequences in skin transcriptome of patients with diffuse systemic sclerosis.Systems level analysis of systemic sclerosis shows a network of immune and profibrotic pathways connected with genetic polymorphisms.Experimentally-derived fibroblast gene signatures identify molecular pathways associated with distinct subsets of systemic sclerosis patients in three independent cohorts.Sustained β-catenin activity in dermal fibroblasts promotes fibrosis by up-regulating expression of extracellular matrix protein-coding genes.Multiplex cytokine analysis of dermal interstitial blister fluid defines local disease mechanisms in systemic sclerosisFibronectinEDA promotes chronic cutaneous fibrosis through Toll-like receptor signaling.Gene expression changes reflect clinical response in a placebo-controlled randomized trial of abatacept in patients with diffuse cutaneous systemic sclerosisMolecular characterization of systemic sclerosis esophageal pathology identifies inflammatory and proliferative signaturesThe Histone Deacetylase Sirtuin 1 Is Reduced in Systemic Sclerosis and Abrogates Fibrotic Responses by Targeting Transforming Growth Factor β Signaling.Nilotinib (Tasigna™) in the treatment of early diffuse systemic sclerosis: an open-label, pilot clinical trialEditorial: Scleroderma: Bringing a Disease From Black-and-White Into TechnicolorSkin gene expression correlates of severity of interstitial lung disease in systemic sclerosis.Integrated, multicohort analysis of systemic sclerosis identifies robust transcriptional signature of disease severity.A novel multi-network approach reveals tissue-specific cellular modulators of fibrosis in systemic sclerosis.Current status of systemic sclerosis biomarkers: applications for diagnosis, management and drug development.Personalized medicine in systemic sclerosis: facts and promises.Biomarkers in Scleroderma: Progressing from Association to Clinical Utility.Clinical Trial Design Issues in Systemic Sclerosis: an Update.Systematic approach to understanding the pathogenesis of systemic sclerosis.Identification of Optimal Mouse Models of Systemic Sclerosis by Interspecies Comparative Genomics.Connective tissue diseases: systemic sclerosis: beyond limited and diffuse subsets?Novel lung imaging biomarkers and skin gene expression subsetting in dasatinib treatment of systemic sclerosis-associated interstitial lung disease.Targeted apoptosis of myofibroblasts with the BH3 mimetic ABT-263 reverses established fibrosis.Identification of novel systemic sclerosis biomarkers employing aptamer proteomic analysis.Endogenous ligands of TLR4 promote unresolving tissue fibrosis: Implications for systemic sclerosis and its targeted therapy.Belimumab for the Treatment of Early Diffuse Systemic Sclerosis: Results of a Randomized, Double-Blind, Placebo-Controlled, Pilot Trial.Thinking BIG rheumatology: how to make functional genomics data work for you.A modified murine model of systemic sclerosis: bleomycin given by pump infusion induced skin and pulmonary inflammation and fibrosis.The mechanistic implications of gene expression studies in SSc: Insights from Systems BiologyPharmacological Inhibition of Toll-Like Receptor-4 Signaling by TAK242 Prevents and Induces Regression of Experimental Organ Fibrosis
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Molecular signatures in skin associated with clinical improvement during mycophenolate treatment in systemic sclerosis
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 14 March 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Molecular signatures in skin a ...... reatment in systemic sclerosis
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Molecular signatures in skin a ...... eatment in systemic sclerosis.
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type
label
Molecular signatures in skin a ...... reatment in systemic sclerosis
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Molecular signatures in skin a ...... eatment in systemic sclerosis.
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prefLabel
Molecular signatures in skin a ...... reatment in systemic sclerosis
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Molecular signatures in skin a ...... eatment in systemic sclerosis.
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Molecular signatures in skin a ...... reatment in systemic sclerosis
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Arlene Sirajuddin
Chiang-Ching Huang
J Matthew Mahoney
John Varga
Jungwha Lee
Mary Carns
Michael L Whitfield
Monique Hinchcliff
Robert Lafyatis
Rowland W Chang
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P2888
P304
P356
10.1038/JID.2013.130
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P577
2013-03-14T00:00:00Z
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P6179
1052111577