The rat oncogenome: comparative genetics and genomics of rat models of mammary carcinogenesis.
about
In vivo microdialysis sampling of adipokines CCL2, IL-6, and leptin in the mammary fat pad of adult female rats.Genetically engineered ERα-positive breast cancer mouse models.Significant overlap between human genome-wide association-study nominated breast cancer risk alleles and rat mammary cancer susceptibility loci.Physical confirmation and mapping of overlapping rat mammary carcinoma susceptibility QTLs, Mcs2 and Mcs6Validation of six genetic determinants of susceptibility to estrogen-induced mammary cancer in the rat and assessment of their relevance to breast cancer risk in humansBAC CGH-array identified specific small-scale genomic imbalances in diploid DMBA-induced rat mammary tumorsMultiple susceptibility loci for radiation-induced mammary tumorigenesis in F2[Dahl S x R]-intercross rats.Association of cellular and molecular responses in the rat mammary gland to 17β-estradiol with susceptibility to mammary cancer4-Vinylcyclohexene diepoxide (VCD) inhibits mammary epithelial differentiation and induces fibroadenoma formation in female Sprague Dawley rats.Development and characterization of a novel rat model of estrogen-induced mammary cancer.Tamoxifen induces regression of estradiol-induced mammary cancer in the ACI.COP-Ept2 rat model.Rat Mcs1b is concordant to the genome-wide association-identified breast cancer risk locus at human 5q11.2 and MIER3 is a candidate cancer susceptibility gene.Mapping of three genetic determinants of susceptibility to estrogen-induced mammary cancer within the Emca8 locus on rat chromosome 5.Tissue-specific actions of the Ept1, Ept2, Ept6, and Ept9 genetic determinants of responsiveness to estrogens in the female rat.Exposure to estrogen and ionizing radiation causes epigenetic dysregulation, activation of mitogen-activated protein kinase pathways, and genome instability in the mammary gland of ACI rats.Rat Models of 17beta-Estradiol-Induced Mammary Cancer Reveal Novel Insights into Breast Cancer Etiology and Prevention.Genetic variation in sensitivity to estrogens and breast cancer risk.
P2860
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P2860
The rat oncogenome: comparative genetics and genomics of rat models of mammary carcinogenesis.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on January 2007
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
The rat oncogenome: comparativ ...... els of mammary carcinogenesis.
@en
The rat oncogenome: comparativ ...... els of mammary carcinogenesis.
@nl
type
label
The rat oncogenome: comparativ ...... els of mammary carcinogenesis.
@en
The rat oncogenome: comparativ ...... els of mammary carcinogenesis.
@nl
prefLabel
The rat oncogenome: comparativ ...... els of mammary carcinogenesis.
@en
The rat oncogenome: comparativ ...... els of mammary carcinogenesis.
@nl
P356
P1433
P1476
The rat oncogenome: comparativ ...... dels of mammary carcinogenesis
@en
P2093
James D Shull
P356
10.3233/BD-2007-28108
P577
2007-01-01T00:00:00Z