A new role for HIV nucleocapsid protein in modulating the specificity of plus strand priming.
about
Viral reverse transcriptases show selective high affinity binding to DNA-DNA primer-templates that resemble the polypurine tract.Role of HIV-1 nucleocapsid protein in HIV-1 reverse transcription.Nucleocapsid protein annealing of a primer-template enhances (+)-strand DNA synthesis and fidelity by HIV-1 reverse transcriptase.A protein ballet around the viral genome orchestrated by HIV-1 reverse transcriptase leads to an architectural switch: from nucleocapsid-condensed RNA to Vpr-bridged DNA.Zinc finger function of HIV-1 nucleocapsid protein is required for removal of 5'-terminal genomic RNA fragments: a paradigm for RNA removal reactions in HIV-1 reverse transcription.Fidelity of plus-strand priming requires the nucleic acid chaperone activity of HIV-1 nucleocapsid protein.Implications of the nucleocapsid and the microenvironment in retroviral reverse transcription.Specific implications of the HIV-1 nucleocapsid zinc fingers in the annealing of the primer binding site complementary sequences during the obligatory plus strand transfer.
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P2860
A new role for HIV nucleocapsid protein in modulating the specificity of plus strand priming.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 15 July 2008
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
A new role for HIV nucleocapsi ...... ficity of plus strand priming.
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A new role for HIV nucleocapsi ...... ficity of plus strand priming.
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type
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A new role for HIV nucleocapsi ...... ficity of plus strand priming.
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A new role for HIV nucleocapsi ...... ficity of plus strand priming.
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prefLabel
A new role for HIV nucleocapsi ...... ficity of plus strand priming.
@en
A new role for HIV nucleocapsi ...... ficity of plus strand priming.
@nl
P2860
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A new role for HIV nucleocapsi ...... ficity of plus strand priming.
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P2093
Deena T Jacob
Jeffrey J DeStefano
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P304
P356
10.1016/J.VIROL.2008.06.002
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P577
2008-07-15T00:00:00Z