Metabolomics guides rational development of a simplified cell culture medium for drug screening against Trypanosoma brucei.
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Structure-Based Design and Synthesis of Antiparasitic Pyrrolopyrimidines Targeting Pteridine Reductase 1Revisiting the central metabolism of the bloodstream forms of Trypanosoma brucei: production of acetate in the mitochondrion is essential for parasite viabilityBenznidazole biotransformation and multiple targets in Trypanosoma cruzi revealed by metabolomicsDietary nitrogen alters codon bias and genome composition in parasitic microorganismsCrystal structure of an arginase-like protein from Trypanosoma brucei that evolved without a binuclear manganese cluster.Independent pathways can transduce the life-cycle differentiation signal in Trypanosoma brucei.Probing the metabolic network in bloodstream-form Trypanosoma brucei using untargeted metabolomics with stable isotope labelled glucoseAntiparasitic chemotherapy: from genomes to mechanisms.LM14 defined medium enables continuous growth of Trypanosoma cruziThe Flagellar Arginine Kinase in Trypanosoma brucei Is Important for Infection in Tsetse FliesGMP synthase is essential for viability and infectivity of Trypanosoma brucei despite a redundant purine salvage pathway.Targeting the parasite's DNA with methyltriazenyl purine analogs is a safe, selective, and efficacious antitrypanosomal strategyLC-MS-based absolute metabolite quantification: application to metabolic flux measurement in trypanosomes.Metabolomics Identifies Multiple Candidate Biomarkers to Diagnose and Stage Human African Trypanosomiasis.Arginine and Lysine Transporters Are Essential for Trypanosoma bruceiThe silicon trypanosome: a test case of iterative model extension in systems biology.Bloodstream form pre-adaptation to the tsetse fly in Trypanosoma brucei.Trypanosoma brucei metabolite indolepyruvate decreases HIF-1α and glycolysis in macrophages as a mechanism of innate immune evasion.Metabolomic-based strategies for anti-parasite drug discovery.Metabolomics - the complementary field in systems biology: a review on obesity and type 2 diabetes.Extracellular Microbial Metabolomics: The State of the Art.Mitochondrial pyruvate carrier in Trypanosoma brucei.The animal trypanosomiases and their chemotherapy: a reviewOrnithine uptake and the modulation of drug sensitivity in Trypanosoma brucei.Metabolomic profiling reveals a finely tuned, starvation-induced metabolic switch in Trypanosoma cruzi epimastigotes.A paradigm shift: The mitoproteomes of procyclic and bloodstream Trypanosoma brucei are comparably complex.Evaluation of the Trypanosoma brucei 6-oxopurine salvage pathway as a potential target for drug discovery.Benzoxaborole treatment perturbs S-adenosyl-L-methionine metabolism in Trypanosoma brucei.KinetoplasteaThe trypanocidal benzoxaborole AN7973 inhibits trypanosome mRNA processingWhat role can metabolomics play in the discovery and development of new medicines for infectious diseases?Metabolomics and lipidomics reveal perturbation of sphingolipid metabolism by a novel anti-trypanosomal 3-(oxazolo[4,5-b]pyridine-2-yl)anilide
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Metabolomics guides rational development of a simplified cell culture medium for drug screening against Trypanosoma brucei.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 09 April 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Metabolomics guides rational d ...... ng against Trypanosoma brucei.
@en
Metabolomics guides rational d ...... ng against Trypanosoma brucei.
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type
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Metabolomics guides rational d ...... ng against Trypanosoma brucei.
@en
Metabolomics guides rational d ...... ng against Trypanosoma brucei.
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Metabolomics guides rational d ...... ng against Trypanosoma brucei.
@en
Metabolomics guides rational d ...... ng against Trypanosoma brucei.
@nl
P2860
P50
P356
P1476
Metabolomics guides rational d ...... ing against Trypanosoma brucei
@en
P2093
Keith R Matthews
Michael P Barrett
P2860
P304
P356
10.1128/AAC.00044-13
P407
P577
2013-04-09T00:00:00Z