Targeted mutations that ablate either the adenylate cyclase or hemolysin function of the bifunctional cyaA toxin of Bordetella pertussis abolish virulence
about
Pertussis toxin and adenylate cyclase toxin provide a one-two punch for establishment of Bordetella pertussis infection of the respiratory tractPertussis toxin and adenylate cyclase toxin: key virulence factors of Bordetella pertussis and cell biology toolsThe adenylate cyclase toxin of Bordetella pertussis binds to target cells via the alpha(M)beta(2) integrin (CD11b/CD18)Adenylate cyclase toxin (ACT) from Bordetella hinzii: characterization and differences from ACT of Bordetella pertussisAdenylate cyclase toxin from Bordetella pertussis synergizes with lipopolysaccharide to promote innate interleukin-10 production and enhances the induction of Th2 and regulatory T cells.CyaC-mediated activation is important not only for toxic but also for protective activities of Bordetella pertussis adenylate cyclase-hemolysin.Stereotyped and specific gene expression programs in human innate immune responses to bacteria.Probing the function of Bordetella bronchiseptica adenylate cyclase toxin by manipulating host immunity.Suppression of platelet aggregation by Bordetella pertussis adenylate cyclase toxin.Stimulation of Bordetella pertussis adenylate cyclase toxin intoxication by its hemolysin domainA novel sensor kinase is required for Bordetella bronchiseptica to colonize the lower respiratory tractThe C-terminal domain is essential for protective activity of the Bordetella pertussis adenylate cyclase-hemolysin.Cell-invasive activity of epitope-tagged adenylate cyclase of Bordetella pertussis allows in vitro presentation of a foreign epitope to CD8+ cytotoxic T cells.Bordetella pertussis infection of primary human monocytes alters HLA-DR expression.Elucidating the in vivo targets of bacterial toxins.Adenylate cyclase toxin-hemolysin relevance for pertussis vaccines.Genomic insights of Pannonibacter phragmitetus strain 31801 isolated from a patient with a liver abscess.Cyclic AMP-Elevating Capacity of Adenylate Cyclase Toxin-Hemolysin Is Sufficient for Lung Infection but Not for Full Virulence of Bordetella pertussis.Pore-forming and enzymatic activities of Bordetella pertussis adenylate cyclase toxin synergize in promoting lysis of monocytes.Adenylate cyclase toxin-mediated delivery of the S1 subunit of pertussis toxin into mammalian cells.Cloning of Prevotella intermedia loci demonstrating multiple hemolytic domains.Structure-Function Relationships Underlying the Capacity of Bordetella Adenylate Cyclase Toxin to Disarm Host Phagocytes.
P2860
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P2860
Targeted mutations that ablate either the adenylate cyclase or hemolysin function of the bifunctional cyaA toxin of Bordetella pertussis abolish virulence
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on June 1992
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Targeted mutations that ablate ...... la pertussis abolish virulence
@en
Targeted mutations that ablate ...... a pertussis abolish virulence.
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type
label
Targeted mutations that ablate ...... la pertussis abolish virulence
@en
Targeted mutations that ablate ...... a pertussis abolish virulence.
@nl
prefLabel
Targeted mutations that ablate ...... la pertussis abolish virulence
@en
Targeted mutations that ablate ...... a pertussis abolish virulence.
@nl
P2093
P2860
P356
P1476
Targeted mutations that ablate ...... la pertussis abolish virulence
@en
P2093
P2860
P304
P356
10.1073/PNAS.89.11.4898
P407
P577
1992-06-01T00:00:00Z