In vitro suppression of serum elastase-inhibitory capacity by reactive oxygen species generated by phagocytosing polymorphonuclear leukocytes.
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Cell surface-bound elastase and cathepsin G on human neutrophils: a novel, non-oxidative mechanism by which neutrophils focus and preserve catalytic activity of serine proteinasesRole of oxidants in microbial pathophysiologyEndothelial cell cytotoxicity in inflammatory vascular diseases--the possible role of oxidised lipoproteins.Human neutrophil elastase modulates platelet function by limited proteolysis of membrane glycoproteins.Respiratory burst activity of intestinal macrophages in normal and inflammatory bowel diseaseTissue injury in inflammation. Oxidants, proteinases, and cationic proteins.Neutrophils degrade subendothelial matrices in the presence of alpha-1-proteinase inhibitor. Cooperative use of lysosomal proteinases and oxygen metabolites.Free-radical chemistry of cigarette smoke and its toxicological implications.Pathogenesis of the adult respiratory distress syndrome. Evidence of oxidant activity in bronchoalveolar lavage fluid.Z-type alpha 1-antitrypsin is less competent than M1-type alpha 1-antitrypsin as an inhibitor of neutrophil elastase.Risk factors for emphysema. Cigarette smoking is associated with a reduction in the association rate constant of lung alpha 1-antitrypsin for neutrophil elastase.Lung injury induced by leukocytic proteases.Pericellular proteolysis by neutrophils in the presence of proteinase inhibitors: effects of substrate opsonizationHigh-level production of biologically active human alpha 1-antitrypsin in Escherichia coli.Potential mechanism of emphysema: alpha 1-proteinase inhibitor recovered from lungs of cigarette smokers contains oxidized methionine and has decreased elastase inhibitory capacity.Oxidized proteins and their contribution to redox homeostasis.Elastase-mediated fibrinogenolysis by chemoattractant-stimulated neutrophils occurs in the presence of physiologic concentrations of antiproteinasesElastase release by transmigrating neutrophils deactivates endothelial-bound SDF-1alpha and attenuates subsequent T lymphocyte transendothelial migrationWhat we owe to alpha(1)-antitrypsin and to Carl-Bertil Laurell.Phagocytes, toxic oxygen metabolites and inflammatory bowel disease: implications for treatment.Oxidative regulation of neutrophil elastase-alpha-1-proteinase inhibitor interactionsAntielastases of the human alveolar structures. Implications for the protease-antiprotease theory of emphysemaPotential mediator of inflammation. Phagocyte-derived oxidants suppress the elastase-inhibitory capacity of alpha 1-proteinase inhibitor in vitro.Chemotactic factor inactivation by the myeloperoxidase-hydrogen peroxide-halide system.Roles for proteinases in the pathogenesis of chronic obstructive pulmonary disease.Elastase-induced pulmonary emphysema: insights from experimental models.Oxygen free radicals, inflammation, and synovitis: and synovitis: the current status.The Pseudomonas aeruginosa secretory product pyocyanin inactivates alpha1 protease inhibitor: implications for the pathogenesis of cystic fibrosis lung disease.alpha 1-Antitrypsin: molecular pathology, leukocytes, and tissue damage.The role of granulocytes in inflammation.Macrophage activation, chronic inflammation and gastrointestinal disease.Antioxidants in neonatal lung disease.Development of an assay for in vivo human neutrophil elastase activity. Increased elastase activity in patients with alpha 1-proteinase inhibitor deficiencyIntravascular activation of complement and acute lung injury. Dependency on neutrophils and toxic oxygen metabolites.Proteolysis by neutrophils. Relative importance of cell-substrate contact and oxidative inactivation of proteinase inhibitors in vitro.Neutrophil-mediated endothelial injury in vitro mechanisms of cell detachment.Elastase of U-937 monocytelike cells. Comparisons with elastases derived from human monocytes and neutrophils and murine macrophagelike cells.Respiratory burst of neutrophils enhances in hemorrhagic fever with renal syndrome (HFRS).Radical approach to the acute respiratory distress syndrome.Complement membrane attack complex stimulates production of reactive oxygen metabolites by cultured rat mesangial cells.
P2860
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P2860
In vitro suppression of serum elastase-inhibitory capacity by reactive oxygen species generated by phagocytosing polymorphonuclear leukocytes.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on April 1979
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
In vitro suppression of serum ...... polymorphonuclear leukocytes.
@en
In vitro suppression of serum ...... polymorphonuclear leukocytes.
@nl
type
label
In vitro suppression of serum ...... polymorphonuclear leukocytes.
@en
In vitro suppression of serum ...... polymorphonuclear leukocytes.
@nl
prefLabel
In vitro suppression of serum ...... polymorphonuclear leukocytes.
@en
In vitro suppression of serum ...... polymorphonuclear leukocytes.
@nl
P2860
P356
P1476
In vitro suppression of serum ...... polymorphonuclear leukocytes.
@en
P2860
P304
P356
10.1172/JCI109364
P407
P577
1979-04-01T00:00:00Z