The volatile anesthetic isoflurane perturbs conformational activation of integrin LFA-1 by binding to the allosteric regulatory cavity
about
Crystal structure of isoflurane bound to integrin LFA-1 supports a unified mechanism of volatile anesthetic action in the immune and central nervous systemsSepsis pathophysiology and anesthetic considerationStereoselectivity of isoflurane in adhesion molecule leukocyte function-associated antigen-1Volatile anesthetics, not intravenous anesthetic propofol bind to and attenuate the activation of platelet receptor integrin αIIbβ3.Sedative drug modulates T-cell and lymphocyte function-associated antigen-1 function.Isoflurane binds and stabilizes a closed conformation of the leukocyte function-associated antigen-1.Differential effects of volatile anesthetics on leukocyte integrin macrophage-1 antigen.Anesthesia, surgery, illness and Alzheimer's diseaseIsoflurane inhibits neutrophil recruitment in the cutaneous Arthus reaction model.Propofol shares the binding site with isoflurane and sevoflurane on leukocyte function-associated antigen-1.Sevoflurane binds and allosterically blocks integrin lymphocyte function-associated antigen-1.Mechanisms revealed through general anesthetic photolabeling.Choice of anesthetic technique on plasma concentrations of interleukins and cell adhesion molecules.Surgical and pharmacological animal models used in drug metabolism and pharmacokinetics.The effect of different anesthetics on tumor cytotoxicity by natural killer cells.Shedding Light on Anesthetic Mechanisms: Application of Photoaffinity Ligands.Mechanisms of the Immunological Effects of Volatile Anesthetics: A ReviewAzi-isoflurane, a Photolabel Analog of the Commonly Used Inhaled General Anesthetic IsofluraneFrom the Cover: Prolonged Exposure to Volatile Anesthetic Isoflurane Worsens the Outcome of Polymicrobial Abdominal Sepsis.Volatile Anesthetic Isoflurane Attenuates Liver Injury in Experimental Polymicrobial Sepsis Model.
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The volatile anesthetic isoflurane perturbs conformational activation of integrin LFA-1 by binding to the allosteric regulatory cavity
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
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scientific article published on 15 August 2008
@en
vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
The volatile anesthetic isoflu ...... e allosteric regulatory cavity
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The volatile anesthetic isoflu ...... allosteric regulatory cavity.
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type
label
The volatile anesthetic isoflu ...... e allosteric regulatory cavity
@en
The volatile anesthetic isoflu ...... allosteric regulatory cavity.
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prefLabel
The volatile anesthetic isoflu ...... e allosteric regulatory cavity
@en
The volatile anesthetic isoflu ...... allosteric regulatory cavity.
@nl
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P356
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The volatile anesthetic isoflu ...... e allosteric regulatory cavity
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P2093
Clay Bracken
Koichi Yuki
Motomu Shimaoka
Nathan S Astrof
Ronnie Yoo
Sulpicio G Soriano
Whitney Silkworth
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P304
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10.1096/FJ.08-113324
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P577
2008-08-15T00:00:00Z