Comprehensive alpha, beta and delta cell transcriptomes reveal that ghrelin selectively activates delta cells and promotes somatostatin release from pancreatic islets.
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Obestatin stimulates glucose-induced insulin secretion through ghrelin receptor GHS-R.The Transcription Factor Nfatc2 Regulates β-Cell Proliferation and Genes Associated with Type 2 Diabetes in Mouse and Human Islets.Transcriptome analysis of pancreatic cells across distant species highlights novel important regulator genes.β1-Adrenergic receptor deficiency in ghrelin-expressing cells causes hypoglycemia in susceptible individuals.The regulator of G-protein signaling RGS16 promotes insulin secretion and β-cell proliferation in rodent and human islets.A Single-Cell Transcriptome Atlas of the Human Pancreas.PAX6 maintains β cell identity by repressing genes of alternative islet cell types.Single-cell transcriptomes identify human islet cell signatures and reveal cell-type-specific expression changes in type 2 diabetes.Functional identification of islet cell types by electrophysiological fingerprinting.Analysis of Purified Pancreatic Islet Beta and Alpha Cell Transcriptomes Reveals 11β-Hydroxysteroid Dehydrogenase (Hsd11b1) as a Novel Disallowed Gene.Development of Fluorinated Non-Peptidic Ghrelin Receptor Ligands for Potential Use in Molecular Imaging.Hypoglycemic Effect of Combined Ghrelin and Glucagon Receptor Blockade.Pancreatic α- and β-cellular clocks have distinct molecular properties and impact on islet hormone secretion and gene expression.The Rab-GTPase activating protein, TBC1D1, is critical for maintaining normal glucose homeostasis and β-cell mass.Immunohistochemical assessment of glucagon-like peptide 1 receptor (GLP-1R) expression in the pancreas of patients with type 2 diabetes.Ghrelin function in human obesity and type 2 diabetes: a concise review.Epigenetic control of β-cell function and failure.Genomics of Islet (Dys)function and Type 2 Diabetes.Intra-islet endothelial cell and β-cell crosstalk: Implication for islet cell transplantation.Transcriptomic profiling of pancreatic alpha, beta and delta cell populations identifies delta cells as a principal target for ghrelin in mouse islets.How stable is repression of disallowed genes in pancreatic islets in response to metabolic stress?Systematic single-cell analysis provides new insights into heterogeneity and plasticity of the pancreas.Interrogating islets in health and disease with single-cell technologiesAlpha TC1 and Beta-TC-6 genomic profiling uncovers both shared and distinct transcriptional regulatory features with their primary islet counterparts.Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men.δ-cells and β-cells are electrically coupled and regulate α-cell activity via somatostatin.Ghrelin as a Survival Hormone.Biphasic voltage-dependent inactivation of human NaV 1.3, 1.6 and 1.7 Na+ channels expressed in rodent insulin-secreting cells.Vitamin D Switches BAF Complexes to Protect β Cells.Ablation of somatostatin cells leads to impaired pancreatic islet function and neonatal death in rodents.TALK-1 reduces delta-cell endoplasmic reticulum and cytoplasmic calcium levels limiting somatostatin secretion.Islet Long Noncoding RNAs: A Playbook for Discovery and CharacterizationGLP-1 suppresses glucagon secretion in human pancreatic alpha-cells by inhibition of P/Q-type Ca channels
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Comprehensive alpha, beta and delta cell transcriptomes reveal that ghrelin selectively activates delta cells and promotes somatostatin release from pancreatic islets.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 03 May 2016
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Comprehensive alpha, beta and ...... elease from pancreatic islets.
@en
Comprehensive alpha, beta and ...... elease from pancreatic islets.
@nl
type
label
Comprehensive alpha, beta and ...... elease from pancreatic islets.
@en
Comprehensive alpha, beta and ...... elease from pancreatic islets.
@nl
prefLabel
Comprehensive alpha, beta and ...... elease from pancreatic islets.
@en
Comprehensive alpha, beta and ...... elease from pancreatic islets.
@nl
P2093
P2860
P1433
P1476
Comprehensive alpha, beta and ...... release from pancreatic islets
@en
P2093
Christopher Cowing-Zitron
Cynthia J Donaldson
Glyn M Noguchi
Joan Vaughan
Michael R DiGruccio
Talitha van der Meulen
P2860
P304
P356
10.1016/J.MOLMET.2016.04.007
P577
2016-05-03T00:00:00Z