Key roles for the lipid signaling enzyme phospholipase d1 in the tumor microenvironment during tumor angiogenesis and metastasis. - Wikidata - awgldk - TriplyDB

Key roles for the lipid signaling enzyme phospholipase d1 in the tumor microenvironment during tumor angiogenesis and metastasis.

Key roles for the lipid signaling enzyme phospholipase d1 in the tumor microenvironment during tumor angiogenesis and metastasis.

http://www.wikidata.org/entity/Q37041152

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Coronin 1B regulates S1P-induced human lung endothelial cell chemotaxis: role of PLD2, protein kinase C and Rac1 signal transduction Functional regulation of phospholipase D expression in cancer and inflammation Targeting Cdc42 in cancer Mechanism of enzymatic reaction and protein-protein interactions of PLD from a 3D structural model.The phospholipase D superfamily as therapeutic targets Phospholipases D1 and D2 Suppress Appetite and Protect against Overweight Two sites of action for PLD2 inhibitors: The enzyme catalytic center and an allosteric, phosphoinositide biding pocket.Phospholipase D in cell signaling: from a myriad of cell functions to cancer growth and metastasis.Cellular and physiological roles for phospholipase D1 in cancer.Brucine suppresses colon cancer cells growth via mediating KDR signalling pathway.Phospholipase D signaling pathways and phosphatidic acid as therapeutic targets in cancer Antitumor action of a novel histone deacetylase inhibitor, YF479, in breast cancer.Deficiencies of the lipid-signaling enzymes phospholipase D1 and D2 alter cytoskeletal organization, macrophage phagocytosis, and cytokine-stimulated neutrophil recruitment.Inhibition of phospholipase D2 induces autophagy in colorectal cancer cells Phospholipase D1 facilitates second-phase myoblast fusion and skeletal muscle regeneration Targeting phospholipase D1 attenuates intestinal tumorigenesis by controlling β-catenin signaling in cancer-initiating cells.The Phospholipase D2 Knock Out Mouse Has Ectopic Purkinje Cells and Suffers from Early Adult-Onset Anosmia.Phosphatidic Acid (PA) can Displace PPARα/LXRα Binding to The EGFR Promoter Causing its Transrepression in Luminal Cancer Cells PLD-Specific Small-Molecule Inhibitors Decrease Tumor-Associated Macrophages and Neutrophils Infiltration in Breast Tumors and Lung and Liver Metastases.Physiological and pathophysiological roles for phospholipase D.Phospholipase D2 promotes degradation of hypoxia-inducible factor-1α independent of lipase activity.The chromosome 3q26 OncCassette: A multigenic driver of human cancer.Angiogenic gene signature in human pancreatic cancer correlates with TGF-beta and inflammatory transcriptomes.Phospholipase D2 mediates survival signaling through direct regulation of Akt in glioblastoma cells.PLD1 regulates adipogenic differentiation through mTOR - IRS-1 phosphorylation at serine 636/639.Phosphatidic acid, phospholipase D and tumorigenesis.A feedback mechanism between PLD and deadenylase PARN for the shortening of eukaryotic poly(A) mRNA tails that is deregulated in cancer cells.Phospholipase D (PLD) drives cell invasion, tumor growth and metastasis in a human breast cancer xenograph model.Simultaneous high expression of PLD1 and Sp1 predicts a poor prognosis for pancreatic ductal adenocarcinoma patients.Emerging roles of lipid metabolism in cancer metastasis.Role of phospholipase d in g-protein coupled receptor function Phospholipase D2 loss results in increased blood pressure via inhibition of the endothelial nitric oxide synthase pathway.Targeting Phospholipid Metabolism in Cancer.PLD1 overexpression promotes invasion and migration and function as a risk factor for Chinese glioma patients.Molecular mechanisms of N-formyl-methionyl-leucyl-phenylalanine-induced superoxide generation and degranulation in mouse neutrophils: phospholipase D is dispensable.Phosphatidic acid-dependent recruitment and function of the Rac activator DOCK1 during dorsal ruffle formation.Thematic minireview series on phospholipase D and cancer.Phospholipase D and Its Essential Role in Cancer.Tissue microarray staining reveals PLD1 and Sp1 have a collaborative, pro-tumoral effect in patients with osteosarcomas.Measuring Phospholipase D Enzymatic Activity Through Biochemical and Imaging Methods.

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Key roles for the lipid signaling enzyme phospholipase d1 in the tumor microenvironment during tumor angiogenesis and metastasis.

http://www.wikidata.org/entity/Q37041152

description

2012 nî lūn-bûn

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2012年の論文

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2012年學術文章

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2012年學術文章

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name

Key roles for the lipid signal ...... r angiogenesis and metastasis.

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Key roles for the lipid signal ...... r angiogenesis and metastasis.

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type

label

Key roles for the lipid signal ...... r angiogenesis and metastasis.

@en

Key roles for the lipid signal ...... r angiogenesis and metastasis.

@nl

prefLabel

Key roles for the lipid signal ...... r angiogenesis and metastasis.

@en

Key roles for the lipid signal ...... r angiogenesis and metastasis.

@nl

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Science Signaling

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Key roles for the lipid signal ...... r angiogenesis and metastasis.

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Adrianus van der Velden

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Bernhard Nieswandt

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Gilbert Di Paolo

http://www.w3.org/2001/XMLSchema#string

Huasong Tian

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Julie-Ann Cavallo

http://www.w3.org/2001/XMLSchema#string

Michael A Frohman

http://www.w3.org/2001/XMLSchema#string

Qin Chen

http://www.w3.org/2001/XMLSchema#string

Takanobu Sato

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Tsunaki Hongu

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Wahida Ali

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P2860

A single autophosphorylation site on KDR/Flk-1 is essential for VEGF-A-dependent activation of PLC-gamma and DNA synthesis in vascular endothelial cells

Modes of resistance to anti-angiogenic therapy

Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis

The genomic landscapes of human breast and colorectal cancers

The adaptor protein shb binds to tyrosine 1175 in vascular endothelial growth factor (VEGF) receptor-2 and regulates VEGF-dependent cellular migration

Phospholipase D: a lipid centric review

Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis

Autophagy and metabolism

Phospholipase d2 ablation ameliorates Alzheimer's disease-linked synaptic dysfunction and cognitive deficits.

Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness.

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