Liquid Chromatographic Determination of NSC 737664 (ABT-888: an Inhibitor of Poly(ADP-ribose) Polymerase (PARP)) in Plasma and Urine in a Phase 0 Clinical Trial
about
A rapid and sensitive method for determination of veliparib (ABT-888), in human plasma, bone marrow cells and supernatant by using LC/MS/MS.Alteration of poly(ADP-ribose) metabolism affects murine sperm nuclear architecture by impairing pericentric heterochromatin condensation.Increased poly(ADP-ribosyl)ation in skeletal muscle tissue of pediatric patients with severe burn injury: prevention by propranolol treatment.Phase I study of PARP inhibitor ABT-888 in combination with topotecan in adults with refractory solid tumors and lymphomasPhase 0 clinical trial of the poly (ADP-ribose) polymerase inhibitor ABT-888 in patients with advanced malignancies.Phase-0/microdosing studies using PET, AMS, and LC-MS/MS: a range of study methodologies and conduct considerations. Accelerating development of novel pharmaceuticals through safe testing in humans - a practical guide.
P2860
Liquid Chromatographic Determination of NSC 737664 (ABT-888: an Inhibitor of Poly(ADP-ribose) Polymerase (PARP)) in Plasma and Urine in a Phase 0 Clinical Trial
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on January 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Liquid Chromatographic Determi ...... ne in a Phase 0 Clinical Trial
@en
Liquid Chromatographic Determination of NSC 737664
@nl
type
label
Liquid Chromatographic Determi ...... ne in a Phase 0 Clinical Trial
@en
Liquid Chromatographic Determination of NSC 737664
@nl
prefLabel
Liquid Chromatographic Determi ...... ne in a Phase 0 Clinical Trial
@en
Liquid Chromatographic Determination of NSC 737664
@nl
P2093
P2860
P1476
Liquid Chromatographic Determi ...... ne in a Phase 0 Clinical Trial
@en
P2093
Eva Majerova
Kimberly D Hill
Lawrence R Phillips
P2860
P304
P356
10.1080/10826070802603351
P577
2009-01-01T00:00:00Z