Protein phosphatase 2A inactivates Bcl2's antiapoptotic function by dephosphorylation and up-regulation of Bcl2-p53 binding.
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Small-Molecule Bcl2 BH4 Antagonist for Lung Cancer TherapyA review of ceramide analogs as potential anticancer agentsNeuroprotectin D1 induces dephosphorylation of Bcl-xL in a PP2A-dependent manner during oxidative stress and promotes retinal pigment epithelial cell survivalBEX2 has a functional interplay with c-Jun/JNK and p65/RelA in breast cancer.From the Biology of PP2A to the PADs for Therapy of Hematologic MalignanciesInhibition of protein phosphatase 2A (PP2A) prevents Mcl-1 protein dephosphorylation at the Thr-163/Ser-159 phosphodegron, dramatically reducing expression in Mcl-1-amplified lymphoma cells.Characterization of biosynthetic genes of ascamycin/dealanylascamycin featuring a 5'-O-sulfonamide moiety in Streptomyces sp. JCM9888.The essential role of evasion from cell death in cancer.Endogenous signaling by omega-3 docosahexaenoic acid-derived mediators sustains homeostatic synaptic and circuitry integritySphingolipids: regulators of crosstalk between apoptosis and autophagySorafenib and pemetrexed toxicity in cancer cells is mediated via SRC-ERK signalingResistance to BH3 mimetic S1 in SCLC cells that up-regulate and phosphorylate Bcl-2 through ERK1/2.Novel Ser/Thr protein phosphatases in cell death regulationEmerging Raf inhibitors.p53 and regulation of bioactive sphingolipids.Regulation of DNA fragmentation: the role of caspases and phosphorylation.p53 and Ceramide as Collaborators in the Stress ResponseAlterations of tau and VASP during microcystin-LR-induced cytoskeletal reorganization in a human liver cell line.PKR negatively regulates leukemia progression in association with PP2A activation, Bcl-2 inhibition and increased apoptosis.Erucylphosphohomocholine, the first intravenously applicable alkylphosphocholine, is cytotoxic to acute myelogenous leukemia cells through JNK- and PP2A-dependent mechanisms.Transient PP2A inhibition alleviates normal tissue stem cell susceptibility to cell death during radiotherapy.A feedback loop between BEX2 and ErbB2 mediated by c-Jun signaling in breast cancer.C-ceramide is a natural regulatory ligand of p53 in cellular stress response
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P2860
Protein phosphatase 2A inactivates Bcl2's antiapoptotic function by dephosphorylation and up-regulation of Bcl2-p53 binding.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 09 October 2008
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Protein phosphatase 2A inactiv ...... egulation of Bcl2-p53 binding.
@en
Protein phosphatase 2A inactiv ...... egulation of Bcl2-p53 binding.
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type
label
Protein phosphatase 2A inactiv ...... egulation of Bcl2-p53 binding.
@en
Protein phosphatase 2A inactiv ...... egulation of Bcl2-p53 binding.
@nl
prefLabel
Protein phosphatase 2A inactiv ...... egulation of Bcl2-p53 binding.
@en
Protein phosphatase 2A inactiv ...... egulation of Bcl2-p53 binding.
@nl
P2093
P2860
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P1476
Protein phosphatase 2A inactiv ...... egulation of Bcl2-p53 binding.
@en
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Fengqin Gao
W Stratford May
Xingming Deng
P2860
P304
P356
10.1182/BLOOD-2008-06-165134
P407
P577
2008-10-09T00:00:00Z