Laforin prevents stress-induced polyglucosan body formation and Lafora disease progression in neurons.
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Does abnormal glycogen structure contribute to increased susceptibility to seizures in epilepsy?Activation of serum/glucocorticoid-induced kinase 1 (SGK1) underlies increased glycogen levels, mTOR activation, and autophagy defects in Lafora disease.Laforin-malin complex degrades polyglucosan bodies in concert with glycogen debranching enzyme and brain isoform glycogen phosphorylaseA novel image-based high-throughput screening assay discovers therapeutic candidates for adult polyglucosan body disease.Glycogen synthase protects neurons from cytotoxicity of mutant huntingtin by enhancing the autophagy flux.Triacylglycerol mimetics regulate membrane interactions of glycogen branching enzyme: implications for therapy.Polyglucosan neurotoxicity caused by glycogen branching enzyme deficiency can be reversed by inhibition of glycogen synthase.
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Laforin prevents stress-induced polyglucosan body formation and Lafora disease progression in neurons.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 02 April 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Laforin prevents stress-induce ...... isease progression in neurons.
@en
Laforin prevents stress-induce ...... isease progression in neurons.
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type
label
Laforin prevents stress-induce ...... isease progression in neurons.
@en
Laforin prevents stress-induce ...... isease progression in neurons.
@nl
prefLabel
Laforin prevents stress-induce ...... isease progression in neurons.
@en
Laforin prevents stress-induce ...... isease progression in neurons.
@nl
P2093
P2860
P1476
Laforin prevents stress-induce ...... isease progression in neurons.
@en
P2093
Berge A Minassian
Helen Zhang
Jack M Parent
Peixiang Wang
P2860
P2888
P356
10.1007/S12035-013-8438-2
P577
2013-04-02T00:00:00Z