Identification of substituted pyrimido[5,4-b]indoles as selective Toll-like receptor 4 ligands - Wikidata - awgldk - TriplyDB

Identification of substituted pyrimido[5,4-b]indoles as selective Toll-like receptor 4 ligands

Identification of substituted pyrimido[5,4-b]indoles as selective Toll-like receptor 4 ligands

http://www.wikidata.org/entity/Q37043647

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Computational Approaches to Toll-Like Receptor 4 Modulation Synthetic Toll-like receptor 4 (TLR4) and TLR7 ligands as influenza virus vaccine adjuvants induce rapid, sustained, and broadly protective responses Identification of Adjuvantic Activity of Amphotericin B in a Novel, Multiplexed, Poly-TLR/NLR High-Throughput Screen.Rationally Designed TLR4 Ligands for Vaccine Adjuvant Discovery Toll-like receptor 4 (TLR4) modulation by synthetic and natural compounds: an update.Novel synthetic toll-like receptor 4/MD2 ligands attenuate sterile inflammation Discovery of substituted 4-aminoquinazolines as selective Toll-like receptor 4 ligands.Adjuvants in the Driver's Seat: How Magnitude, Type, Fine Specificity and Longevity of Immune Responses Are Driven by Distinct Classes of Immune Potentiators CD14 dependence of TLR4 endocytosis and TRIF signaling displays ligand specificity and is dissociable in endotoxin tolerance Discovery and Structure-Activity Relationships of the Neoseptins: A New Class of Toll-like Receptor-4 (TLR4) Agonists.A Novel Class of Small Molecule Agonists with Preference for Human over Mouse TLR4 Activation Modulation of Innate Immune Responses via Covalently Linked TLR Agonists.TLR4/MD-2 activation by a synthetic agonist with no similarity to LPS.Immune Response Modulation of Conjugated Agonists with Changing Linker Length Directing the immune system with chemical compounds.Strategies for designing synthetic immune agonists.Synthetic Toll-Like Receptor 4 (TLR4) and TLR7 Ligands Work Additively via MyD88 To Induce Protective Antiviral Immunity in Mice.A Light-Controlled TLR4 Agonist and Selectable Activation of Cell Subpopulations Structure-Activity Relationship Studies of Pyrimido[5,4-b]indoles as Selective Toll-Like Receptor 4 Ligands.Identification of Biologically Active Pyrimido[5,4-b]indoles That Prolong NF-κB Activation without Intrinsic Activity.The Role of Carbohydrates in the Lipopolysaccharide (LPS)/Toll-Like Receptor 4 (TLR4) Signalling.Rational Design of a New Class of Toll-Like Receptor 4 (TLR4) Tryptamine Related Agonists by Means of the Structure- and Ligand-Based Virtual Screening for Vaccine Adjuvant Discovery.

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P2860

Identification of substituted pyrimido[5,4-b]indoles as selective Toll-like receptor 4 ligands

http://www.wikidata.org/entity/Q37043647

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

@pt

bilimsel makale

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scientific article published on 24 May 2013

@en

vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Identification of substituted ...... e Toll-like receptor 4 ligands

@en

Identification of substituted ...... Toll-like receptor 4 ligands.

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type

label

Identification of substituted ...... e Toll-like receptor 4 ligands

@en

Identification of substituted ...... Toll-like receptor 4 ligands.

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prefLabel

Identification of substituted ...... e Toll-like receptor 4 ligands

@en

Identification of substituted ...... Toll-like receptor 4 ligands.

@nl

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Journal of Medicinal Chemistry

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Identification of substituted ...... e Toll-like receptor 4 ligands

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Afshin Nour

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Brian Crain

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Dennis A Carson

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Howard B Cottam

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Igor F Tsigelny

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Karen Messer

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Maripat Corr

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Michael Chan

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Minya Pu

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Richard D Mathewson

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P2860

MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4

A Toll-like receptor recognizes bacterial DNA

The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex

Evidence that tricyclic small molecules may possess toll-like receptor and myeloid differentiation protein 2 activity

Activation of anti-hepatitis C virus responses via Toll-like receptor 7.

Structural basis of species-specific endotoxin sensing by innate immune receptor TLR4/MD-2

A human homologue of the Drosophila Toll protein signals activation of adaptive immunity

NF-kappaB regulation in the immune system

Evidence that opioids may have toll-like receptor 4 and MD-2 effects

Cutting edge: a novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling

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4206-4223

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scholarly article

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10.1021/JM301694X

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11

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56

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2013-05-24T00:00:00Z

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23656327

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Toll-like receptor

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