The Cdk1-APC/C cell cycle oscillator circuit functions as a time-delayed, ultrasensitive switch.
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Ultrasensitivity part III: cascades, bistable switches, and oscillatorsFeedback loops and reciprocal regulation: recurring motifs in the systems biology of the cell cycleChanges in oscillatory dynamics in the cell cycle of early Xenopus laevis embryosHow Does the Xenopus laevis Embryonic Cell Cycle Avoid Spatial Chaos?Interphase APC/C-Cdc20 inhibition by cyclin A2-Cdk2 ensures efficient mitotic entry.Protein Phosphatases Involved in Regulating Mitosis: Facts and HypothesesModels in biology: lessons from modeling regulation of the eukaryotic cell cycleMitotic trigger waves and the spatial coordination of the Xenopus cell cycle.Timing of Tissue-specific Cell Division Requires a Differential Onset of Zygotic Transcription during Metazoan Embryogenesis.Phosphorylation-mediated stabilization of Bora in mitosis coordinates Plx1/Plk1 and Cdk1 oscillationsUltrasensitivity part I: Michaelian responses and zero-order ultrasensitivity.Cell cycle control by a minimal Cdk network.Spatial trigger waves: positive feedback gets you a long way.Bistability, oscillations, and traveling waves in frog egg extracts.Ultrasensitivity part II: multisite phosphorylation, stoichiometric inhibitors, and positive feedback.Cell cycle gene expression networks discovered using systems biology: Significance in carcinogenesisControl of βAR- and N-methyl-D-aspartate (NMDA) Receptor-Dependent cAMP Dynamics in Hippocampal Neurons.Robustness of cell cycle control and flexible orders of signaling eventsErroneous Silencing of the Mitotic Checkpoint by Aberrant Spindle Pole-Kinetochore Coordination.Build to understand: synthetic approaches to biologyMechanism of APC/CCDC20 activation by mitotic phosphorylation.Role for regulated phosphatase activity in generating mitotic oscillations in Xenopus cell-free extracts.Dependency of the spindle assembly checkpoint on Cdk1 renders the anaphase transition irreversible.How oocytes try to get it right: spindle checkpoint control in meiosis.Emerging mechanisms regulating mitotic synchrony during animal embryogenesis.Role of DNA binding sites and slow unbinding kinetics in titration-based oscillators.Measuring time during early embryonic development.Identifying ultrasensitive HGF dose-response functions in a 3D mammalian system for synthetic morphogenesis.PP1 initiates the dephosphorylation of MASTL, triggering mitotic exit and bistability in human cells.Linear-No-Threshold Default Assumptions are Unwarranted for Cytotoxic Endpoints Independently Triggered by Ultrasensitive Molecular Switches.Inefficient degradation of cyclin B1 re-activates the spindle checkpoint right after sister chromatid disjunction.Regulation of Cell Division.Cell Cycle Remodeling and Zygotic Gene Activation at the Midblastula Transition.The big and intricate dreams of little organelles: Embracing complexity in the study of membrane traffic.Ubiquitin-specific protease 22 is a deubiquitinase of CCNB1.Two Bistable Switches Govern M Phase Entry.Positive Feedback Keeps Duration of Mitosis Temporally Insulated from Upstream Cell-Cycle Events.Compartmentalization of a bistable switch enables memory to cross a feedback-driven transition.A cdk1 gradient guides surface contraction waves in oocytes.Adaptation to the spindle checkpoint is regulated by the interplay between Cdc28/Clbs and PP2ACdc55
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The Cdk1-APC/C cell cycle oscillator circuit functions as a time-delayed, ultrasensitive switch.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 28 April 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
The Cdk1-APC/C cell cycle osci ...... elayed, ultrasensitive switch.
@en
The Cdk1-APC/C cell cycle osci ...... elayed, ultrasensitive switch.
@nl
type
label
The Cdk1-APC/C cell cycle osci ...... elayed, ultrasensitive switch.
@en
The Cdk1-APC/C cell cycle osci ...... elayed, ultrasensitive switch.
@nl
prefLabel
The Cdk1-APC/C cell cycle osci ...... elayed, ultrasensitive switch.
@en
The Cdk1-APC/C cell cycle osci ...... elayed, ultrasensitive switch.
@nl
P2860
P356
P1433
P1476
The Cdk1-APC/C cell cycle osci ...... elayed, ultrasensitive switch.
@en
P2093
James E Ferrell
Qiong Yang
P2860
P2888
P304
P356
10.1038/NCB2737
P577
2013-04-28T00:00:00Z