Noninvasive monitoring of pharmacodynamics and kinetics of a death receptor 5 antibody and its enhanced apoptosis induction in sequential application with doxorubicin
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Glycoengineering of therapeutic antibodies enhances monocyte/macrophage-mediated phagocytosis and cytotoxicityApoptosis imaging for monitoring DR5 antibody accumulation and pharmacodynamics in brain tumors noninvasively.Pharmacodynamic assays to facilitate preclinical and clinical development of pre-mRNA splicing modulatory drug candidates.Tumor priming by Apo2L/TRAIL reduces interstitial fluid pressure and enhances efficacy of liposomal gemcitabine in a patient derived xenograft tumor model.Preclinical activity of combined HDAC and KDM1A inhibition in glioblastoma.Understanding of tolerance in TRAIL-induced apoptosis and cancelation of its machinery by α-mangostin, a xanthone derivativeCancer subclonal genetic architecture as a key to personalized medicine.Improved decision making for prioritizing tumor targeting antibodies in human xenografts: Utility of fluorescence imaging to verify tumor target expression, antibody binding and optimization of dosage and application scheduleThe role of the TNF receptors and apoptosis inducing ligands in tumor growth.
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P2860
Noninvasive monitoring of pharmacodynamics and kinetics of a death receptor 5 antibody and its enhanced apoptosis induction in sequential application with doxorubicin
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on August 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Noninvasive monitoring of phar ...... l application with doxorubicin
@en
Noninvasive monitoring of phar ...... application with doxorubicin.
@nl
type
label
Noninvasive monitoring of phar ...... l application with doxorubicin
@en
Noninvasive monitoring of phar ...... application with doxorubicin.
@nl
prefLabel
Noninvasive monitoring of phar ...... l application with doxorubicin
@en
Noninvasive monitoring of phar ...... application with doxorubicin.
@nl
P2093
P2860
P356
P1433
P1476
Noninvasive monitoring of phar ...... l application with doxorubicin
@en
P2093
Alnawaz Rehemtulla
Stefanie Galbán
Thomas G Weber
Thomas Pöschinger
Werner Scheuer
P2860
P304
P356
10.1593/NEO.13932
P577
2013-08-01T00:00:00Z