The regulation and function of Class III PI3Ks: novel roles for Vps34.
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Pathogenic mechanisms in centronuclear myopathiesNRBF2 regulates macroautophagy as a component of Vps34 Complex INRBF2 regulates autophagy and prevents liver injury by modulating Atg14L-linked phosphatidylinositol-3 kinase III activityAutophagosome targeting and membrane curvature sensing by Barkor/Atg14(L).A mammalian autophagosome maturation mechanism mediated by TECPR1 and the Atg12-Atg5 conjugateThe RUN domain of rubicon is important for hVps34 binding, lipid kinase inhibition, and autophagy suppressionArchitecture and dynamics of the autophagic phosphatidylinositol 3-kinase complexExtreme-longevity mutations orchestrate silencing of multiple signaling pathwayshVps15, but not Ca2+/CaM, is required for the activity and regulation of hVps34 in mammalian cellsArabidopsis FAB1/PIKfyve proteins are essential for development of viable pollenApolipoprotein L1, a novel Bcl-2 homology domain 3-only lipid-binding protein, induces autophagic cell deathThe role of amino acid-induced mammalian target of rapamycin complex 1(mTORC1) signaling in insulin resistanceHow PI3K-derived lipids control cell divisionClass III phosphatidylinositol 3-kinase and its catalytic product PtdIns3P in regulation of endocytic membrane trafficAutophagy in cellular metabolism and cancerMembrane trafficking and phagosome maturation during the clearance of apoptotic cellsUbiquitination and phosphorylation of Beclin 1 and its binding partners: Tuning class III phosphatidylinositol 3-kinase activity and tumor suppressionEmerging strategies to effectively target autophagy in cancerPhosphoinositides: tiny lipids with giant impact on cell regulationPhosphoinositides in the mammalian endo-lysosomal networkNeuregulin promotes incomplete autophagy of prostate cancer cells that is independent of mTOR pathway inhibitionPhosphatidylinositol 3-monophosphate is involved in toxoplasma apicoplast biogenesisTwo PI 3-kinases and one PI 3-phosphatase together establish the cyclic waves of phagosomal PtdIns(3)P critical for the degradation of apoptotic cellsMultiple phosphatidylinositol 3-kinases regulate vaccinia virus morphogenesisStructure and Function of Vps15 in the Endosomal G Protein Signaling Pathway ,Shaping Development of Autophagy Inhibitors with the Structure of the Lipid Kinase Vps34A HORMA domain in Atg13 mediates PI 3-kinase recruitment in autophagyImperfect interface of Beclin1 coiled-coil domain regulates homodimer and heterodimer formation with Atg14L and UVRAGA highly potent and selective Vps34 inhibitor alters vesicle trafficking and autophagyAtg38 is required for autophagy-specific phosphatidylinositol 3-kinase complex integrity.Disrupting vesicular trafficking at the endosome attenuates transcriptional activation by Gcn4.The therapeutic potential of targeting the PI3K pathway in pediatric brain tumorsDifferential regulatory functions of three classes of phosphatidylinositol and phosphoinositide 3-kinases in autophagyDifferential regulation of distinct Vps34 complexes by AMPK in nutrient stress and autophagyReceptor signaling lymphocyte-activation molecule family 1 (Slamf1) regulates membrane fusion and NADPH oxidase 2 (NOX2) activity by recruiting a Beclin-1/Vps34/ultraviolet radiation resistance-associated gene (UVRAG) complexSignaling by the phosphoinositide 3-kinase family in immune cellsNutritional and contractile regulation of human skeletal muscle protein synthesis and mTORC1 signalingRegulation of mammalian autophagy by class II and III PI 3-kinases through PI3P synthesisLPIAT1 regulates arachidonic acid content in phosphatidylinositol and is required for cortical lamination in miceInvolvement of Beclin 1 in engulfment of apoptotic cells
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The regulation and function of Class III PI3Ks: novel roles for Vps34.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on February 2008
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
The regulation and function of Class III PI3Ks: novel roles for Vps34.
@en
The regulation and function of Class III PI3Ks: novel roles for Vps34.
@nl
type
label
The regulation and function of Class III PI3Ks: novel roles for Vps34.
@en
The regulation and function of Class III PI3Ks: novel roles for Vps34.
@nl
prefLabel
The regulation and function of Class III PI3Ks: novel roles for Vps34.
@en
The regulation and function of Class III PI3Ks: novel roles for Vps34.
@nl
P356
P1433
P1476
The regulation and function of Class III PI3Ks: novel roles for Vps34.
@en
P2093
Jonathan M Backer
P356
10.1042/BJ20071427
P407
P577
2008-02-01T00:00:00Z