Physiological consequences of the P2328S mutation in the ryanodine receptor (RyR2) gene in genetically modified murine hearts.
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Acute atrial arrhythmogenesis in murine hearts following enhanced extracellular Ca(2+) entry depends on intracellular Ca(2+) stores.Pharmacological changes in cellular Ca2+ homeostasis parallel initiation of atrial arrhythmogenesis in murine Langendorff-perfused hearts.Arrhythmic effects of Epac-mediated ryanodine receptor activation in Langendorff-perfused murine hearts are associated with reduced conduction velocity.Ryanodine receptor channelopathies.Acute atrial arrhythmogenicity and altered Ca(2+) homeostasis in murine RyR2-P2328S hearts.Generation and characterization of a mouse model harboring the exon-3 deletion in the cardiac ryanodine receptor.In silico prediction of drug therapy in catecholaminergic polymorphic ventricular tachycardia.The RyR2-P2328S mutation downregulates Nav1.5 producing arrhythmic substrate in murine ventricles.Abnormal Ca(2+) homeostasis, atrial arrhythmogenesis, and sinus node dysfunction in murine hearts modeling RyR2 modificationRyanodine receptor studies using genetically engineered mice.An introduction to murine models of atrial fibrillationMurine Electrophysiological Models of Cardiac Arrhythmogenesis.Ca2+ signaling in human induced pluripotent stem cell-derived cardiomyocytes (iPS-CM) from normal and catecholaminergic polymorphic ventricular tachycardia (CPVT)-afflicted subjects.Multiple targets for flecainide action: implications for cardiac arrhythmogenesis.Calcium Signaling and Cardiac Arrhythmias.Arrhythmogenic actions of the Ca2+ channel agonist FPL-64716 in Langendorff-perfused murine hearts.Flecainide exerts paradoxical effects on sodium currents and atrial arrhythmia in murine RyR2-P2328S hearts.Alternans in genetically modified langendorff-perfused murine hearts modeling catecholaminergic polymorphic ventricular tachycardia.A novel ryanodine receptor mutation linked to sudden death increases sensitivity to cytosolic calcium.Bridging the dimensions of research on cardiac ryanodine receptor mutations.Effects of ageing on pro-arrhythmic ventricular phenotypes in incrementally paced murine Pgc-1β -/- hearts.Pro-arrhythmic atrial phenotypes in incrementally paced murine Pgc1β-/- hearts: effects of age.Epac-induced ryanodine receptor type 2 activation inhibits sodium currents in atrial and ventricular murine cardiomyocytes.Cardiomyocyte ionic currents in intact young and aged murine Pgc-1β-/- atrial preparations.Loss of Nav1.5 expression and function in murine atria containing the RyR2-P2328S gain-of-function mutation.Atrial arrhythmia, triggering events and conduction abnormalities in isolated murine RyR2-P2328S hearts.Ventricular pro-arrhythmic phenotype, arrhythmic substrate, ageing and mitochondrial dysfunction in peroxisome proliferator activated receptor-γ coactivator-1β deficient (Pgc-1β-/-) murine hearts.
P2860
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P2860
Physiological consequences of the P2328S mutation in the ryanodine receptor (RyR2) gene in genetically modified murine hearts.
description
article científic
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article scientifique
@fr
articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 28 June 2008
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Physiological consequences of ...... ically modified murine hearts.
@en
Physiological consequences of the P2328S mutation in the ryanodine receptor
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type
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Physiological consequences of ...... ically modified murine hearts.
@en
Physiological consequences of the P2328S mutation in the ryanodine receptor
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prefLabel
Physiological consequences of ...... ically modified murine hearts.
@en
Physiological consequences of the P2328S mutation in the ryanodine receptor
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P2093
P2860
P1433
P1476
Physiological consequences of ...... ically modified murine hearts.
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P2093
A J Williams
C A Goddard
C L-H Huang
W H Colledge
P2860
P304
P356
10.1111/J.1748-1716.2008.01865.X
P577
2008-06-28T00:00:00Z