Inactivating mutations of RNF43 confer Wnt dependency in pancreatic ductal adenocarcinoma - Wikidata - awgldk - TriplyDB

Inactivating mutations of RNF43 confer Wnt dependency in pancreatic ductal adenocarcinoma

Inactivating mutations of RNF43 confer Wnt dependency in pancreatic ductal adenocarcinoma

http://www.wikidata.org/entity/Q37068621

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Wnt Signaling in Cancer Stem Cell Biology Control of Wnt Receptor Turnover by R-spondin-ZNRF3/RNF43 Signaling Module and Its Dysregulation in Cancer Bridging academic science and clinical research in the search for novel targeted anti-cancer agents Genomic alterations in pancreatic cancer and their relevance to therapy Chemical Disruption of Wnt-dependent Cell Fate Decision-making Mechanisms in Cancer and Regenerative Medicine Pancreatic adenocarcinoma pathology: changing "landscape"Keeping Wnt signalosome in check by vesicular traffic Wnt signaling pathway in non-small cell lung cancer Genetics of the serrated pathway to colorectal cancer Structures of Wnt-Antagonist ZNRF3 and Its Complex with R-Spondin 1 and Implications for Signaling Diversity of Precursor Lesions For Pancreatic Cancer: The Genetics and Biology of Intraductal Papillary Mucinous Neoplasm Differentiation of mesenchymal stem cells into cardiomyocytes is regulated by miRNA-1-2 via WNT signaling pathway The CREB-binding protein inhibitor ICG-001 suppresses pancreatic cancer growth.Oral epithelial stem cells - implications in normal development and cancer metastasis.Updating the Wnt pathways.Targeting the Wnt/β-catenin pathway in primary ovarian cancer with the porcupine inhibitor WNT974.New targeted therapies for breast cancer: A focus on tumor microenvironmental signals and chemoresistant breast cancers RNF43 is frequently mutated in colorectal and endometrial cancers Targeting β-catenin signaling for therapeutic intervention in MEN1-deficient pancreatic neuroendocrine tumours.CD151-α3β1 integrin complexes suppress ovarian tumor growth by repressing slug-mediated EMT and canonical Wnt signaling.Aspartate β-Hydroxylase expression promotes a malignant pancreatic cellular phenotype Moving upstream in the war on WNTs.Whole-exome sequencing of pancreatic cancer defines genetic diversity and therapeutic targets.Molecular Role of RNF43 in Canonical and Noncanonical Wnt Signaling Can we safely target the WNT pathway?Pathological and molecular evaluation of pancreatic neoplasms.Porcupine inhibitor suppresses paracrine Wnt-driven growth of Rnf43;Znrf3-mutant neoplasia.Whole genomes redefine the mutational landscape of pancreatic cancer.Wnt addiction of genetically defined cancers reversed by PORCN inhibition.USP6 oncogene promotes Wnt signaling by deubiquitylating Frizzleds.Identification of quinazoline compounds as novel potent inhibitors of Wnt/β-catenin signaling in colorectal cancer cells.NOTUM is a potential pharmacodynamic biomarker of Wnt pathway inhibition.Genetic Diversity of Pancreatic Ductal Adenocarcinoma and Opportunities for Precision Medicine Activation of WNT/β-Catenin Signaling Enhances Pancreatic Cancer Development and the Malignant Potential Via Up-regulation of Cyr61.Aberrantly expressed LGR4 empowers Wnt signaling in multiple myeloma by hijacking osteoblast-derived R-spondins.The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength Antitumor effect of water decoctions of taxus cuspidate on pancreatic cancer.Diminished WNT -> β-catenin -> c-MYC signaling is a barrier for malignant progression of BRAFV600E-induced lung tumors RNF43 and ZNRF3 are commonly altered in serrated pathway colorectal tumorigenesis.Adenocarcinoma of the pancreas

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Inactivating mutations of RNF43 confer Wnt dependency in pancreatic ductal adenocarcinoma

http://www.wikidata.org/entity/Q37068621

description

article científic

@ca

article scientifique

@fr

articolo scientifico

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artigo científico

@pt

bilimsel makale

@tr

scientific article published on 11 July 2013

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

Inactivating mutations of RNF43 confer Wnt dependency in pancreatic ductal adenocarcinoma

@en

Inactivating mutations of RNF4 ...... creatic ductal adenocarcinoma.

@nl

type

label

Inactivating mutations of RNF43 confer Wnt dependency in pancreatic ductal adenocarcinoma

@en

Inactivating mutations of RNF4 ...... creatic ductal adenocarcinoma.

@nl

prefLabel

Inactivating mutations of RNF43 confer Wnt dependency in pancreatic ductal adenocarcinoma

@en

Inactivating mutations of RNF4 ...... creatic ductal adenocarcinoma.

@nl

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PNAS.1307218110

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Proceedings of the National Academy of Sciences of the United States of America

P1476

Inactivating mutations of RNF43 confer Wnt dependency in pancreatic ductal adenocarcinoma

@en

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Bo Lu

http://www.w3.org/2001/XMLSchema#string

Cindy Bottiglio

http://www.w3.org/2001/XMLSchema#string

Feng Cong

http://www.w3.org/2001/XMLSchema#string

Huai-Xiang Hao

http://www.w3.org/2001/XMLSchema#string

Jeffery A Porter

http://www.w3.org/2001/XMLSchema#string

Joseph D Growney

http://www.w3.org/2001/XMLSchema#string

Jun Liu

http://www.w3.org/2001/XMLSchema#string

Linda Bagdasarian

http://www.w3.org/2001/XMLSchema#string

Margaret E McLaughlin

http://www.w3.org/2001/XMLSchema#string

Mindy H Hsieh

http://www.w3.org/2001/XMLSchema#string

P2860

Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors

Identification of c-MYC as a target of the APC pathway

Oncogenic function of ATDC in pancreatic cancer through Wnt pathway activation and beta-catenin stabilization

Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling

ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner

Wnt/beta-catenin signaling: components, mechanisms, and diseases

Targeted disruption of the BCL9/β-catenin complex inhibits oncogenic Wnt signaling

Wnt/beta-catenin signaling in development and disease

The Wnt signaling pathway in development and disease

Monounsaturated fatty acid modification of Wnt protein: its role in Wnt secretion

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scholarly article

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10.1073/PNAS.1307218110

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110

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2013-07-11T00:00:00Z

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248706126

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23847203

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