Aryl bis(diazeniumdiolates): potent inducers of S-glutathionylation of cellular proteins and their in vitro antiproliferative activities
about
Cross-linking protein glutathionylation mediated by O2-arylated bis-diazeniumdiolate "Double JS-K".Stabilization of the nitric oxide (NO) prodrugs and anticancer leads, PABA/NO and Double JS-K, through incorporation into PEG-protected nanoparticlesCellular redox imbalance and changes of protein S-glutathionylation patterns are associated with senescence induced by oncogenic H-rasSynthesis and evaluation of piperazine and homopiperazine analogues of JS-K, an anti-cancer lead compound.A highly selective sulfinate ester probe for thiol bioimaging.2-Acetylamino-3-[4-(2-acetylamino-2-carboxyethylsulfanylcarbonylamino) phenyl carbamoylsulfanyl] propionic acid, a glutathione reductase inhibitor, induces G2/M cell cycle arrest through generation of thiol oxidative stress in human esophageal canceCombination of betulinic acid with diazen-1-ium-1,2-diolate nitric oxide moiety donating a novel anticancer candidate.
P2860
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P2860
Aryl bis(diazeniumdiolates): potent inducers of S-glutathionylation of cellular proteins and their in vitro antiproliferative activities
description
article científic
@ca
article scientifique
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articolo scientifico
@it
artigo científico
@pt
bilimsel makale
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scientific article published on December 2008
@en
vedecký článok
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vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
@cs
name
Aryl bis
@nl
Aryl bis(diazeniumdiolates): p ...... o antiproliferative activities
@en
type
label
Aryl bis
@nl
Aryl bis(diazeniumdiolates): p ...... o antiproliferative activities
@en
prefLabel
Aryl bis
@nl
Aryl bis(diazeniumdiolates): p ...... o antiproliferative activities
@en
P2093
P2860
P356
P1476
Aryl bis(diazeniumdiolates): p ...... o antiproliferative activities
@en
P2093
Anna E Maciag
Daniela Andrei
Harinath Chakrapani
Joseph E Saavedra
Larry K Keefer
Michael L Citro
P2860
P304
P356
10.1021/JM800831Y
P407
P577
2008-12-01T00:00:00Z