Aldose reductase regulates high glucose-induced ectodomain shedding of tumor necrosis factor (TNF)-alpha via protein kinase C-delta and TNF-alpha converting enzyme in vascular smooth muscle cells.
about
High glucose exposure promotes activation of protein phosphatase 2A in rodent islets and INS-1 832/13 β-cells by increasing the posttranslational carboxylmethylation of its catalytic subunitPKCα and PKCδ regulate ADAM17-mediated ectodomain shedding of heparin binding-EGF through separate pathways.Aldose reductase inhibition prevents endotoxin-induced inflammatory responses in retinal microglia.ADAM-17: the enzyme that does it all.Tumor necrosis factor-alpha converting enzyme: Implications for ocular inflammatory diseasesBryostatin 1 inhibits phorbol ester-induced apoptosis in prostate cancer cells by differentially modulating protein kinase C (PKC) delta translocation and preventing PKCdelta-mediated release of tumor necrosis factor-alpha.IL-1beta signals through the EGF receptor and activates Egr-1 through MMP-ADAM.ALDOSE REDUCTASE: New Insights for an Old Enzyme.Aldose Reductase Mediates Transforming Growth Factor β2 (TGF-β2)-Induced Migration and Epithelial-To-Mesenchymal Transition of Lens-Derived Epithelial Cells.Aldose reductase, oxidative stress, and diabetic mellitus.ADAM17 regulates TNFα production by placental trophoblasts.ADAM17 mediates Nox4 expression and NADPH oxidase activity in the kidney cortex of OVE26 mice.Matrix metalloproteinases in diabetic retinopathy: potential role of MMP-9.ADAM28 is elevated in humans with the metabolic syndrome and is a novel sheddase of human tumour necrosis factor-α.TIMP3 is reduced in atherosclerotic plaques from subjects with type 2 diabetes and increased by SirT1.Mitochondrial reactive oxygen species mediate GPCR-induced TACE/ADAM17-dependent transforming growth factor-alpha shedding.Regulation of urinary ACE2 in diabetic miceInsulin-like growth factor-1 (IGF-1)-induced processing of amyloid-beta precursor protein (APP) and APP-like protein 2 is mediated by different metalloproteinases.Inhibition of Src kinase blocks high glucose-induced EGFR transactivation and collagen synthesis in mesangial cells and prevents diabetic nephropathy in mice.Increased tumor necrosis factor alpha-converting enzyme activity induces insulin resistance and hepatosteatosis in mice.Overexpression of miR-130a-3p/301a-3p attenuates high glucose-induced MPC5 podocyte dysfunction through suppression of TNF-α signaling.Astragaloside IV inhibits PMA-induced EPCR shedding through MAPKs and PKC pathway.Role of the TNF pathway in the progression of diabetic nephropathy in KK-A(y) mice.
P2860
Q28584125-2D958623-0603-486A-9F67-93FFD88C0942Q31001916-0063D473-CD01-434C-A02F-26890FBE7F1FQ33567452-1EDDBD39-6498-40DC-A5B7-9CF2C60683EDQ33737421-5A4E0ED8-75A7-4C2C-8359-11E6241BCD53Q33891912-5238F136-CE11-48B6-A160-6A038DED64F8Q34127963-A9EF2671-F8B3-4645-9A59-2CB3DE9BABA9Q34335737-C3ACEAD8-AB17-457E-A9A8-EFCB44F9F2AEQ34895688-99A9A1B7-06C8-439C-BE77-DA3C2E542377Q35831260-6731EC0B-BEEC-4A88-97FA-EA7FA05850DAQ35947855-48FD5AEB-C33F-4F8A-9F2D-20CA6BAD0F7DQ35988831-83579C20-ADC1-4D1E-B94F-A587F758726DQ37093660-75F48654-C403-4D95-9A36-23D8D188FE5FQ37242419-8CBFC948-D03E-4149-9D1B-4EE323C90E79Q37335291-B861D112-CDD1-4456-ABC8-B08189921432Q37360450-2759F20C-A441-4A62-BF31-57BCD6EC4521Q37475351-1B7D66EC-044A-4BB2-B2B5-80861A11A9B1Q37476622-1C6C35A5-333E-445D-B52A-83060B3A2C1DQ40074092-AF11E0E6-A437-475F-BBE9-982A327588A7Q42936581-3649A7A1-5B2C-44C8-B96A-2D6D8C73A74EQ43251946-E15FA317-74A4-4CE9-A8DA-B013BFADC1C2Q50054250-76BC58DD-1FE4-4EE8-8107-CF0CA0191DE9Q51076108-69BCD8B9-9008-48C3-8D3F-02C9F0FA3117Q53061535-D085D82D-787E-40E4-80D5-31B8636FB1EA
P2860
Aldose reductase regulates high glucose-induced ectodomain shedding of tumor necrosis factor (TNF)-alpha via protein kinase C-delta and TNF-alpha converting enzyme in vascular smooth muscle cells.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 04 September 2008
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Aldose reductase regulates hig ...... vascular smooth muscle cells.
@en
Aldose reductase regulates hig ...... dding of tumor necrosis factor
@nl
type
label
Aldose reductase regulates hig ...... vascular smooth muscle cells.
@en
Aldose reductase regulates hig ...... dding of tumor necrosis factor
@nl
prefLabel
Aldose reductase regulates hig ...... vascular smooth muscle cells.
@en
Aldose reductase regulates hig ...... dding of tumor necrosis factor
@nl
P2093
P2860
P921
P356
P1433
P1476
Aldose reductase regulates hig ...... vascular smooth muscle cells.
@en
P2093
Aramati B M Reddy
Aruni Bhatnagar
Sanjay Srivastava
Satish K Srivastava
P2860
P356
10.1210/EN.2008-0677
P407
P577
2008-09-04T00:00:00Z