PIM-1-specific mAb suppresses human and mouse tumor growth by decreasing PIM-1 levels, reducing Akt phosphorylation, and activating apoptosis.
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PIM serine/threonine kinases in the pathogenesis and therapy of hematologic malignancies and solid cancersCell-permeable Carboxyl-terminal p27Kip1 Peptide Exhibits Anti-tumor Activity by Inhibiting Pim-1 KinaseAssociation of Nuclear PIM1 Expression with Lymph Node Metastasis and Poor Prognosis in Patients with Lung Adenocarcinoma and Squamous Cell CarcinomaPim-1 kinase as cancer drug target: An updatePharmacologic inhibition of Pim kinases alters prostate cancer cell growth and resensitizes chemoresistant cells to taxanes.Androgen deprivation therapy has no effect on Pim-1 expression in a mouse model of prostate cancer.In vitro evaluation of dihydropyridine-3-carbonitriles as potential cytotoxic agents through PIM-1 protein kinase inhibition.Pathophysiological roles of Pim-3 kinase in pancreatic cancer development and progression.Trichomonosis, a common curable STI, and prostate carcinogenesis--a proposed molecular mechanism.Pim-1 kinase is a target of miR-486-5p and eukaryotic translation initiation factor 4E, and plays a critical role in lung cancer.Overexpression of Pim-1 in bladder cancer.Pim1 kinase is upregulated in glioblastoma multiforme and mediates tumor cell survival.Expression of pim-1 in tumors, tumor stroma and tumor-adjacent mucosa co-determines the prognosis of colon cancer patients.EBNA3C augments Pim-1 mediated phosphorylation and degradation of p21 to promote B-cell proliferationPim1 kinase is required to maintain tumorigenicity in MYC-expressing prostate cancer cells.Targeting PIM kinase enhances the activity of sunitinib in renal cell carcinoma.Combinatorial therapy with tamoxifen and trifluoperazine effectively inhibits malignant peripheral nerve sheath tumor growth by targeting complementary signaling cascades.PIM1 regulates glycolysis and promotes tumor progression in hepatocellular carcinomaA Novel Cinnamon-Related Natural Product with Pim-1 Inhibitory Activity Inhibits Leukemia and Skin CancerHuman CD180 Transmits Signals via the PIM-1L Kinase.PIM1 gene cooperates with human BCL6 gene to promote the development of lymphomasInhibition of Pim1 kinase activation attenuates allergen-induced airway hyperresponsiveness and inflammationInvestigational agent MLN9708/2238 targets tumor-suppressor miR33b in MM cells.Functional role and therapeutic potential of the pim-1 kinase in colon carcinoma.Identification of quinones as novel PIM1 kinase inhibitorsU1 adaptors for the therapeutic knockdown of the oncogene pim-1 kinase in glioblastoma.Pim-1 mediated signaling during the process of cardiac remodeling following myocardial infarction in ovine heartsPim kinase inhibitor, SGI-1776, induces apoptosis in chronic lymphocytic leukemia cells.Inflammation and survival pathways: chronic lymphocytic leukemia as a model system.Why target PIM1 for cancer diagnosis and treatment?Expression of proviral integration site for Moloney murine leukemia virus 1 (Pim-1) is post-transcriptionally regulated by tristetraprolin in cancer cells.PIM1 destabilization activates a p53-dependent response to ribosomal stress in cancer cellsThe PIM family of oncoproteins: small kinases with huge implications in myeloid leukemogenesis and as therapeutic targets.RAGE-dependent activation of the oncoprotein Pim1 plays a critical role in systemic vascular remodeling processes.Signal transducers and activators of transcription-3/pim1 axis plays a critical role in the pathogenesis of human pulmonary arterial hypertension.PIM Kinase as an Executional Target in Cancer
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PIM-1-specific mAb suppresses human and mouse tumor growth by decreasing PIM-1 levels, reducing Akt phosphorylation, and activating apoptosis.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 19 January 2009
@en
vedecký článok
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vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
PIM-1-specific mAb suppresses ...... ion, and activating apoptosis.
@en
PIM-1-specific mAb suppresses ...... ion, and activating apoptosis.
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type
label
PIM-1-specific mAb suppresses ...... ion, and activating apoptosis.
@en
PIM-1-specific mAb suppresses ...... ion, and activating apoptosis.
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prefLabel
PIM-1-specific mAb suppresses ...... ion, and activating apoptosis.
@en
PIM-1-specific mAb suppresses ...... ion, and activating apoptosis.
@nl
P2093
P2860
P356
P1476
PIM-1-specific mAb suppresses ...... ion, and activating apoptosis.
@en
P2093
Nancy S Magnuson
Pei Xiang Xing
Scott Vandervalk
Xiu Feng Hu
Zeping Wang
P2860
P304
P356
10.1172/JCI33216
P407
P577
2009-01-19T00:00:00Z