Reduced Shedding of Surface Mesothelin Improves Efficacy of Mesothelin-Targeting Recombinant Immunotoxins

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A re-engineered immunotoxin shows promising preclinical activity in ovarian cancer.Antibody-Drug Conjugates as Cancer Therapeutics: Past, Present, and Future.A new anti-mesothelin antibody targets selectively the membrane-associated form.

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Reduced Shedding of Surface Mesothelin Improves Efficacy of Mesothelin-Targeting Recombinant Immunotoxins

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article científic

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article scientifique

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articolo scientifico

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bilimsel makale

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scientific article published on 18 May 2016

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vetenskaplig artikel

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vědecký článek

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Reduced Shedding of Surface Me ...... eting Recombinant Immunotoxins

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Reduced Shedding of Surface Me ...... ting Recombinant Immunotoxins.

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Reduced Shedding of Surface Me ...... eting Recombinant Immunotoxins

@en

Reduced Shedding of Surface Me ...... ting Recombinant Immunotoxins.

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Reduced Shedding of Surface Me ...... eting Recombinant Immunotoxins

@en

Reduced Shedding of Surface Me ...... ting Recombinant Immunotoxins.

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Reduced Shedding of Surface Me ...... eting Recombinant Immunotoxins

@en

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Ira Pastan

http://www.w3.org/2001/XMLSchema#string

Messan Folivi

http://www.w3.org/2001/XMLSchema#string

Oleg Chertov

http://www.w3.org/2001/XMLSchema#string

Prince Awuah

http://www.w3.org/2001/XMLSchema#string

Tapan K Bera

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Mesothelin-induced pancreatic cancer cell proliferation involves alteration of cyclin E via activation of signal transducer and activator of transcription protein 3

Soluble member(s) of the mesothelin/megakaryocyte potentiating factor family are detectable in sera from patients with ovarian carcinoma

Effect of antigen shedding on targeted delivery of immunotoxins in solid tumors from a mathematical model

Mesothelin is overexpressed in the vast majority of ductal adenocarcinomas of the pancreas: identification of a new pancreatic cancer marker by serial analysis of gene expression (SAGE).

A flow cytometry method to quantitate internalized immunotoxins shows that taxol synergistically increases cellular immunotoxins uptake

Mesothelin is not required for normal mouse development or reproduction.

In vitro and in vivo activity of the low-immunogenic antimesothelin immunotoxin RG7787 in pancreatic cancer.

High interstitial fluid pressure is associated with low tumour penetration of diagnostic monoclonal antibodies applied for molecular imaging purposes.

Efficacy of RG7787, a next-generation mesothelin-targeted immunotoxin, against triple-negative breast and gastric cancers.

Phase II clinical trial of amatuximab, a chimeric antimesothelin antibody with pemetrexed and cisplatin in advanced unresectable pleural mesothelioma

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1648-1655

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scholarly article

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10.1158/1535-7163.MCT-15-0863

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2016-05-18T00:00:00Z

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27196771

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4936933

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Reduced Shedding of Surface Mesothelin Improves Efficacy of Mesothelin-Targeting Recombinant Immunotoxins

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P2860

Reduced Shedding of Surface Mesothelin Improves Efficacy of Mesothelin-Targeting Recombinant Immunotoxins

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