Coupled global and local changes direct substrate translocation by neurotransmitter-sodium symporter ortholog LeuT.
about
Spontaneous inward opening of the dopamine transporter is triggered by PIP2-regulated dynamics of the N-terminusComplete mapping of substrate translocation highlights the role of LeuT N-terminal segment in regulating transport cycleExploring the conformational transitions of biomolecular systems using a simple two-state anisotropic network modelUnveiling the Mechanism of Arginine Transport through AdiC with Molecular Dynamics Simulations: The Guiding Role of Aromatic ResiduesNot just an oil slick: how the energetics of protein-membrane interactions impacts the function and organization of transmembrane proteins.Conformational changes in dopamine transporter intracellular regions upon cocaine binding and dopamine translocationSubstrate transport and anion permeation proceed through distinct pathways in glutamate transporters.Structural dynamics of the monoamine transporter homolog LeuT from accelerated conformational sampling and channel analysisMetadynamics simulations reveal a Na+ independent exiting path of galactose for the inward-facing conformation of vSGLTIdentification of a second substrate-binding site in solute-sodium symporters.Microseconds simulations reveal a new sodium-binding site and the mechanism of sodium-coupled substrate uptake by LeuTNbIT--a new information theory-based analysis of allosteric mechanisms reveals residues that underlie function in the leucine transporter LeuT.Properties of an inward-facing state of LeuT: conformational stability and substrate release.Mechanism of the Association between Na+ Binding and Conformations at the Intracellular Gate in Neurotransmitter:Sodium SymportersComputational characterization of structural dynamics underlying function in active membrane transporters.Functional mechanisms of neurotransmitter transporters regulated by lipid-protein interactions of their terminal loops.The Environment Shapes the Inner Vestibule of LeuT.Energy landscape of LeuT from molecular simulationsStructure-Encoded Global Motions and Their Role in Mediating Protein-Substrate Interactions.Molecular Mechanism of Dopamine Transport by Human Dopamine Transporter.Insights into the Modulation of Dopamine Transporter Function by Amphetamine, Orphenadrine, and Cocaine BindingAtomistic modeling of alternating access of a mitochondrial ADP/ATP membrane transporter with molecular simulations.Sodium-assisted formation of binding and traverse conformations of the substrate in a neurotransmitter sodium symporter model.Conformational Dynamics on the Extracellular Side of LeuT Controlled by Na+ and K+ Ions and the Protonation State of Glu290Quantitative Assessment of the Energetics of Dopamine Translocation by Human Dopamine Transporter.Thermodynamic Coupling Function Analysis of Allosteric Mechanisms in the Human Dopamine Transporter.Allosteric modulation of human dopamine transporter activity under conditions promoting its dimerization.Effect of Dimerization on the Dynamics of Neurotransmitter:Sodium Symporters.Shared dynamics of LeuT superfamily members and allosteric differentiation by structural irregularities and multimerization.Description of LAT1 Transport Mechanism at an Atomistic Level
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Coupled global and local changes direct substrate translocation by neurotransmitter-sodium symporter ortholog LeuT.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on August 2013
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Coupled global and local chang ...... odium symporter ortholog LeuT.
@en
Coupled global and local chang ...... odium symporter ortholog LeuT.
@nl
type
label
Coupled global and local chang ...... odium symporter ortholog LeuT.
@en
Coupled global and local chang ...... odium symporter ortholog LeuT.
@nl
prefLabel
Coupled global and local chang ...... odium symporter ortholog LeuT.
@en
Coupled global and local chang ...... odium symporter ortholog LeuT.
@nl
P2860
P1433
P1476
Coupled global and local chang ...... odium symporter ortholog LeuT.
@en
P2093
Mary Hongying Cheng
P2860
P304
P356
10.1016/J.BPJ.2013.06.032
P407
P50
P577
2013-08-01T00:00:00Z