UV-triggered p21 degradation facilitates damaged-DNA replication and preserves genomic stability - Wikidata - awgldk - TriplyDB

UV-triggered p21 degradation facilitates damaged-DNA replication and preserves genomic stability

UV-triggered p21 degradation facilitates damaged-DNA replication and preserves genomic stability

http://www.wikidata.org/entity/Q37080401

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A mouse model uncovers LKB1 as an UVB-induced DNA damage sensor mediating CDKN1A (p21WAF1/CIP1) degradation Thymine DNA glycosylase is a CRL4Cdt2 substrate.Identification of novel DNA-damage tolerance genes reveals regulation of translesion DNA synthesis by nucleophosmin.The fork and the kinase: a DNA replication tale from a CHK1 perspective.Expression of the p12 subunit of human DNA polymerase δ (Pol δ), CDK inhibitor p21(WAF1), Cdt1, cyclin A, PCNA and Ki-67 in relation to DNA replication in individual cells Mismatch repair proteins recruited to ultraviolet light-damaged sites lead to degradation of licensing factor Cdt1 in the G1 phase.Rad51 recombinase prevents Mre11 nuclease-dependent degradation and excessive PrimPol-mediated elongation of nascent DNA after UV irradiation.Effective intra-S checkpoint responses to UVC in primary human melanocytes and melanoma cell lines Control of Trx1 redox state modulates protection against methyl methanesulfonate-induced DNA damage via stabilization of p21.SOX9 is targeted for proteasomal degradation by the E3 ligase FBW7 in response to DNA damage.Cyclin Kinase-independent role of p21CDKN1A in the promotion of nascent DNA elongation in unstressed cells.PIP degron proteins, substrates of CRL4Cdt2, and not PIP boxes, interfere with DNA polymerase η and κ focus formation on UV damage The identification of translesion DNA synthesis regulators: Inhibitors in the spotlight.Regulation of Rad6/Rad18 Activity During DNA Damage Tolerance.Maintenance of Genome Integrity: How Mammalian Cells Orchestrate Genome Duplication by Coordinating Replicative and Specialized DNA Polymerases.RNA-splicing factor SART3 regulates translesion DNA synthesis.

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UV-triggered p21 degradation facilitates damaged-DNA replication and preserves genomic stability

http://www.wikidata.org/entity/Q37080401

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article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 30 May 2013

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

UV-triggered p21 degradation f ...... nd preserves genomic stability

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UV-triggered p21 degradation f ...... d preserves genomic stability.

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type

label

UV-triggered p21 degradation f ...... nd preserves genomic stability

@en

UV-triggered p21 degradation f ...... d preserves genomic stability.

@nl

prefLabel

UV-triggered p21 degradation f ...... nd preserves genomic stability

@en

UV-triggered p21 degradation f ...... d preserves genomic stability.

@nl

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Nucleic Acids Research

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UV-triggered p21 degradation f ...... nd preserves genomic stability

@en

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Carol Prives

http://www.w3.org/2001/XMLSchema#string

Gastón Soria

http://www.w3.org/2001/XMLSchema#string

Martín Habif

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María Belén Vallerga

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Sabrina F Mansilla

http://www.w3.org/2001/XMLSchema#string

Vanesa Gottifredi

http://www.w3.org/2001/XMLSchema#string

Wilner Martínez-López

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P2860

PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex.

Localization of DNA polymerases eta and iota to the replication machinery is tightly co-ordinated in human cells.

Structural Basis for Novel Interactions between Human Translesion Synthesis Polymerases and Proliferating Cell Nuclear Antigen

Structure of the C-terminal region of p21(WAF1/CIP1) complexed with human PCNA

Regulation of monoubiquitinated PCNA by DUB autocleavage

CDK inhibitor p21 is degraded by a proliferating cell nuclear antigen-coupled Cul4-DDB1Cdt2 pathway during S phase and after UV irradiation

Sequential assembly of the nucleotide excision repair factors in vivo

Requirement for p53 and p21 to sustain G2 arrest after DNA damage

The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA

DNA damage induced Pol eta recruitment takes place independently of the cell cycle phase.

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6942-6951

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scholarly article

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10.1093/NAR/GKT475

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14

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41

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2013-05-30T00:00:00Z

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236977808

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23723248

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3737556

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