A critical role for the sphingosine analog AAL-R in dampening the cytokine response during influenza virus infection.
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Lethal influenza virus infection in macaques is associated with early dysregulation of inflammatory related genesVirus-plus-susceptibility gene interaction determines Crohn's disease gene Atg16L1 phenotypes in intestineActions of a picomolar short-acting S1P₁ agonist in S1P₁-eGFP knock-in miceDiscovery, synthesis and SAR analysis of novel selective small molecule S1P4-R agonists based on a (2Z,5Z)-5-((pyrrol-3-yl)methylene)-3-alkyl-2-(alkylimino)thiazolidin-4-one chemotypeModulating the Innate Immune Response to Influenza A Virus: Potential Therapeutic Use of Anti-Inflammatory DrugsThree phases of CD8 T cell response in the lung following H1N1 influenza infection and sphingosine 1 phosphate agonist therapyPeripheral Leukocyte Migration in Ferrets in Response to Infection with Seasonal Influenza VirusThe draft genome sequence of the ferret (Mustela putorius furo) facilitates study of human respiratory diseaseCompounds with anti-influenza activity: present and future of strategies for the optimal treatment and management of influenza. Part II: Future compounds against influenza virusImmunogenic properties of archaeal species found in bioaerosolsClosely related influenza viruses induce contrasting respiratory tract immunopathologySwitch from protective to adverse inflammation during influenza: viral determinants and hemostasis are caught as culprits.Attenuated Bordetella pertussis protects against highly pathogenic influenza A viruses by dampening the cytokine storm.Host response to influenza virus: protection versus immunopathology.Suppression of cytokine storm with a sphingosine analog provides protection against pathogenic influenza virus.Functional glycosylation of dystroglycan is crucial for thymocyte development in the mouseTreatment with a sphingosine analog does not alter the outcome of a persistent virus infection.Mammalian sphingosine kinase (SphK) isoenzymes and isoform expression: challenges for SphK as an oncotarget.Animal model of respiratory syncytial virus: CD8+ T cells cause a cytokine storm that is chemically tractable by sphingosine-1-phosphate 1 receptor agonist therapy.Discovery, design and synthesis of the first reported potent and selective sphingosine-1-phosphate 4 (S1P4) receptor antagonists.Targeting the sphingosine-1-phosphate axis in cancer, inflammation and beyond.New treatments for influenzaModulation of chemokines and allergic airway inflammation by selective local sphingosine-1-phosphate receptor 1 agonism in lungsDoes cytokine signaling link sphingolipid metabolism to host defense and immunity against virus infections?CD8+ T cells control Ross River virus infection in musculoskeletal tissues of infected mice.A comprehensive map of the influenza A virus replication cycleSphingosine kinase 1 serves as a pro-viral factor by regulating viral RNA synthesis and nuclear export of viral ribonucleoprotein complex upon influenza virus infection.CD4+ T cell help guides formation of CD103+ lung-resident memory CD8+ T cells during influenza viral infectionTreatment with a sphingosine analog after the inception of house dust mite-induced airway inflammation alleviates key features of experimental asthma.SAR analysis of innovative selective small molecule antagonists of sphingosine-1-phosphate 4 (S1P₄) receptor.Sphingosine 1-phosphate in acute dengue infectionA ceramide analogue stimulates dendritic cells to promote T cell responses upon virus infectionsSphingosine-1-phosphate signaling and its role in disease.Myeloid Cell Arg1 Inhibits Control of Arthritogenic Alphavirus Infection by Suppressing Antiviral T CellsInto the eye of the cytokine storm.S1PR1-mediated IFNAR1 degradation modulates plasmacytoid dendritic cell interferon-α autoamplificationEffect of statin treatments on highly pathogenic avian influenza H5N1, seasonal and H1N1pdm09 virus infections in BALB/c miceLessons learned and concepts formed from study of the pathogenesis of the two negative-strand viruses lymphocytic choriomeningitis and influenza.Profile of Michael B. A. Oldstone. Interview by Nicholette Zeliadt.Intranasal Introduction of Fc-Fused Interleukin-7 Provides Long-Lasting Prophylaxis against Lethal Influenza Virus Infection.
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A critical role for the sphingosine analog AAL-R in dampening the cytokine response during influenza virus infection.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 21 January 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
A critical role for the sphing ...... ing influenza virus infection.
@en
A critical role for the sphing ...... ing influenza virus infection.
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type
label
A critical role for the sphing ...... ing influenza virus infection.
@en
A critical role for the sphing ...... ing influenza virus infection.
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prefLabel
A critical role for the sphing ...... ing influenza virus infection.
@en
A critical role for the sphing ...... ing influenza virus infection.
@nl
P2093
P2860
P356
P1476
A critical role for the sphing ...... ing influenza virus infection.
@en
P2093
Bumsuk Hahm
David Marsolais
Dorian McGavern
Hugh Rosen
Kevin B Walsh
Kurt H Edelmann
Michael B A Oldstone
Yasuko Hatta
P2860
P304
P356
10.1073/PNAS.0812689106
P407
P577
2009-01-21T00:00:00Z