DNAzyme technology and cancer therapy: cleave and let die.
about
Cooperative enhancement of deoxyribozyme activity by chemical modification and added cationic copolymerSafety and tolerability of an intratumorally injected DNAzyme, Dz13, in patients with nodular basal-cell carcinoma: a phase 1 first-in-human trial (DISCOVER)Design of a biochemical circuit motif for learning linear functions.Spiegelzymes: sequence specific hydrolysis of L-RNA with mirror image hammerhead ribozymes and DNAzymes.A library of programmable DNAzymes that operate in a cellular environment.EBV-LMP1 targeted DNAzyme enhances radiosensitivity by inhibiting tumor angiogenesis via the JNKs/HIF-1 pathway in nasopharyngeal carcinoma.The importance of peripheral sequences in determining the metal selectivity of an in vitro-selected Co(2+) -dependent DNAzyme.Catalytic deoxyribozyme-modified nanoparticles for RNAi-independent gene regulationAnti-matrix metalloproteinase-9 DNAzyme decreases tumor growth in the MMTV-PyMT mouse model of breast cancer.Biostable L-DNAzyme for Sensing of Metal Ions in Biological Systems.Cancer, chitosan nanoparticles and catalytic nucleic acids.The distribution, clearance, and safety of an anti-MMP-9 DNAzyme in normal and MMTV-PyMT transgenic mice.Targeting EBV-LMP1 DNAzyme enhances radiosensitivity of nasopharyngeal carcinoma cells by inhibiting telomerase activity.Overcoming EGFR T790M-based Tyrosine Kinase Inhibitor Resistance with an Allele-specific DNAzyme.Theranostic DNAzymes.Design and development of antisense drugs.Translational Approaches towards Cancer Gene Therapy: Hurdles and Hopes.Catalytic molecular logic devices by DNAzyme displacement.DNA Catalysis: The Chemical Repertoire of DNAzymes.EBV-LMP1-targeted DNAzyme restrains nasopharyngeal carcinoma growth in a mouse C666-1 xenograft model.A general approach to the design of allosteric, transcription factor-regulated DNAzymes.In vitro selection of small RNA-cleaving deoxyribozymes that cleave pyrimidine-pyrimidine junctions.Coarse-Grained Brownian Dynamics Simulations of the 10-23 DNAzyme.Multi-metal-dependent nucleic acid enzymes.Resurrecting DNAzymes as sequence-specific therapeutics.Metal-Ion-Activated DNAzymes Used for Regulation of Telomerase Activity in Living Cells.Dual effects of a CpG-DNAzyme targeting mutant EGFR transcripts in lung cancer cells: TLR9 activation and EGFR downregulation.Thermodynamic heuristics with case-based reasoning: combined insights for RNA pseudoknot secondary structure.Spatial conservation studies of nucleobases in 10-23 DNAzyme by 2'-positioned isonucleotides and enantiomers for increased activity.A smart DNAzyme-MnO₂ nanosystem for efficient gene silencing.Recent advances in DNAzyme-based gene silencing
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DNAzyme technology and cancer therapy: cleave and let die.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on February 2008
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
DNAzyme technology and cancer therapy: cleave and let die.
@en
DNAzyme technology and cancer therapy: cleave and let die.
@nl
type
label
DNAzyme technology and cancer therapy: cleave and let die.
@en
DNAzyme technology and cancer therapy: cleave and let die.
@nl
prefLabel
DNAzyme technology and cancer therapy: cleave and let die.
@en
DNAzyme technology and cancer therapy: cleave and let die.
@nl
P50
P1476
DNAzyme technology and cancer therapy: cleave and let die
@en
P2093
Crispin R Dass
P304
P356
10.1158/1535-7163.MCT-07-0510
P577
2008-02-01T00:00:00Z