Transgenics, toxicity and therapeutics in rodent models of mutant SOD1-mediated familial ALS.
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A retrospective study of the prevalence of the canine degenerative myelopathy associated superoxide dismutase 1 mutation (SOD1:c.118G > A) in a referral population of German Shepherd dogs from the UKDifferent human copper-zinc superoxide dismutase mutants, SOD1G93A and SOD1H46R, exert distinct harmful effects on gross phenotype in miceDecreased glutathione accelerates neurological deficit and mitochondrial pathology in familial ALS-linked hSOD1(G93A) mice modelOpposite Interplay between PPAR Gamma and Canonical Wnt/Beta-Catenin Pathway in Amyotrophic Lateral SclerosisAdducin at the Neuromuscular Junction in Amyotrophic Lateral Sclerosis: Hanging on for Dear LifeNeuroinflammation in motor neuron diseaseElusive roles for reactive astrocytes in neurodegenerative diseasesOxidative Stress in Neurodegenerative DiseasesStem cell transplantation for motor neuron disease: current approaches and future perspectivesMicroglia centered pathogenesis in ALS: insights in cell interconnectivityTherapeutic neuroprotective agents for amyotrophic lateral sclerosisStem cells in the nervous systemComparative Magnetic Resonance Imaging and Histopathological Correlates in Two SOD1 Transgenic Mouse Models of Amyotrophic Lateral SclerosisINaP selective inhibition reverts precocious inter- and motorneurons hyperexcitability in the Sod1-G93R zebrafish ALS modelInhibitory synaptic regulation of motoneurons: a new target of disease mechanisms in amyotrophic lateral sclerosis.Astrocyte Differentiation of Human Pluripotent Stem Cells: New Tools for Neurological Disorder ResearchA Case for Microtubule Vulnerability in Amyotrophic Lateral Sclerosis: Altered Dynamics During DiseaseNeuroprotective Mechanisms Mediated by CDK5 InhibitionThe complex molecular biology of amyotrophic lateral sclerosis (ALS)Protein disulphide isomerase protects against protein aggregation and is S-nitrosylated in amyotrophic lateral sclerosisCopper delivery to the CNS by CuATSM effectively treats motor neuron disease in SOD(G93A) mice co-expressing the Copper-Chaperone-for-SODEnvironmental enrichment and brain repair: harnessing the therapeutic effects of cognitive stimulation and physical activity to enhance experience-dependent plasticityAblation of proliferating cells in the CNS exacerbates motor neuron disease caused by mutant superoxide dismutaseNeuronal matrix metalloproteinase-9 is a determinant of selective neurodegenerationA novel acylaminoimidazole derivative, WN1316, alleviates disease progression via suppression of glial inflammation in ALS mouse modelMechanisms underlying inflammation in neurodegenerationThe legs at odd angles (Loa) mutation in cytoplasmic dynein ameliorates mitochondrial function in SOD1G93A mouse model for motor neuron disease.A genetic model of amyotrophic lateral sclerosis in zebrafish displays phenotypic hallmarks of motoneuron diseaseAberrant regulation of DNA methylation in amyotrophic lateral sclerosis: a new target of disease mechanisms.A novel SOD1-ALS mutation separates central and peripheral effects of mutant SOD1 toxicityGene expression profiling for human iPS-derived motor neurons from sporadic ALS patients reveals a strong association between mitochondrial functions and neurodegeneration.Experimental Design and Data Analysis Issues Contribute to Inconsistent Results of C-Bouton Changes in Amyotrophic Lateral Sclerosis.TDP-43 expression in mouse models of amyotrophic lateral sclerosis and spinal muscular atrophy.Mutation-dependent polymorphism of Cu,Zn-superoxide dismutase aggregates in the familial form of amyotrophic lateral sclerosis.T₂-weighted MRI detects presymptomatic pathology in the SOD1 mouse model of ALS.Roles of vascular endothelial growth factor in amyotrophic lateral sclerosis.CRISPR/Cas9-mediated targeted gene correction in amyotrophic lateral sclerosis patient iPSCs.Inflammation in ALS and SMA: sorting out the good from the evil.Redox susceptibility of SOD1 mutants is associated with the differential response to CCS over-expression in vivo.Literature-based discovery of diabetes- and ROS-related targets.
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P2860
Transgenics, toxicity and therapeutics in rodent models of mutant SOD1-mediated familial ALS.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 16 January 2008
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Transgenics, toxicity and ther ...... nt SOD1-mediated familial ALS.
@en
Transgenics, toxicity and ther ...... nt SOD1-mediated familial ALS.
@nl
type
label
Transgenics, toxicity and ther ...... nt SOD1-mediated familial ALS.
@en
Transgenics, toxicity and ther ...... nt SOD1-mediated familial ALS.
@nl
prefLabel
Transgenics, toxicity and ther ...... nt SOD1-mediated familial ALS.
@en
Transgenics, toxicity and ther ...... nt SOD1-mediated familial ALS.
@nl
P1476
Transgenics, toxicity and ther ...... nt SOD1-mediated familial ALS.
@en
P2093
Bradley J Turner
Kevin Talbot
P304
P356
10.1016/J.PNEUROBIO.2008.01.001
P577
2008-01-16T00:00:00Z