N-desmethylclozapine, an allosteric agonist at muscarinic 1 receptor, potentiates N-methyl-D-aspartate receptor activity. - Wikidata - awgldk - TriplyDB

N-desmethylclozapine, an allosteric agonist at muscarinic 1 receptor, potentiates N-methyl-D-aspartate receptor activity.

N-desmethylclozapine, an allosteric agonist at muscarinic 1 receptor, potentiates N-methyl-D-aspartate receptor activity.

http://www.wikidata.org/entity/Q37089832

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Subtype-selective allosteric modulators of muscarinic receptors for the treatment of CNS disorders A selective allosteric potentiator of the M1 muscarinic acetylcholine receptor increases activity of medial prefrontal cortical neurons and restores impairments in reversal learning Discovery and characterization of novel allosteric potentiators of M1 muscarinic receptors reveals multiple modes of activity.Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand Cholinergic treatments with emphasis on m1 muscarinic agonists as potential disease-modifying agents for Alzheimer's disease Muscarinic agonists for the treatment of cognition in schizophrenia Small molecule inhibitors of the Candida albicans budded-to-hyphal transition act through multiple signaling pathways A genome-wide RNAi screen in Caenorhabditis elegans identifies the nicotinic acetylcholine receptor subunit ACR-7 as an antipsychotic drug target The antipsychotic potential of muscarinic allosteric modulation Allosteric modulation of the M1 muscarinic acetylcholine receptor: improving cognition and a potential treatment for schizophrenia and Alzheimer's disease Clozapine N-Oxide Administration Produces Behavioral Effects in Long-Evans Rats: Implications for Designing DREADD Experiments.Allosteric activators of muscarinic receptors as novel approaches for treatment of CNS disorders.Selective activation of M4 muscarinic acetylcholine receptors reverses MK-801-induced behavioral impairments and enhances associative learning in rodents.Modulation of prepulse inhibition through both M(1) and M (4) muscarinic receptors in mice Targeting selective activation of M(1) for the treatment of Alzheimer's disease: further chemical optimization and pharmacological characterization of the M(1) positive allosteric modulator ML169.Muscarinic and nicotinic acetylcholine receptor agonists and allosteric modulators for the treatment of schizophrenia Targeting glutamate synapses in schizophrenia Involvement of decreased muscarinic receptor function in prepulse inhibition deficits in mice reared in social isolation.The presynaptic component of the serotonergic system is required for clozapine's efficacy.Discovery and characterization of novel subtype-selective allosteric agonists for the investigation of M(1) receptor function in the central nervous system.Cognitive control deficits in schizophrenia: mechanisms and meaning The Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptors A novel selective muscarinic acetylcholine receptor subtype 1 antagonist reduces seizures without impairing hippocampus-dependent learning Molecular targets for treating cognitive dysfunction in schizophrenia.Molecular mechanisms of action and in vivo validation of an M4 muscarinic acetylcholine receptor allosteric modulator with potential antipsychotic properties Differential regulation of muscarinic M1 receptors by orthosteric and allosteric ligands.Antipsychotic drug action: targets for drug discovery with neurochemical imaging.Cholinergic pairing with visual activation results in long-term enhancement of visual evoked potentials.Allosteric Modulation of Muscarinic Acetylcholine Receptors.Identification of orthosteric and allosteric site mutations in M2 muscarinic acetylcholine receptors that contribute to ligand-selective signaling bias Effect of second-generation antipsychotics on cognition: current issues and future challenges.Structural determinants of allosteric agonism and modulation at the M4 muscarinic acetylcholine receptor: identification of ligand-specific and global activation mechanisms.Fine-tuning of awake prefrontal cortex neurons by clozapine: comparison with haloperidol and N-desmethylclozapine.Investigating the interaction of McN-A-343 with the M muscarinic receptor using its nitrogen mustard derivative and ACh mustard.Molecular mechanisms of bitopic ligand engagement with the M1 muscarinic acetylcholine receptor Treatments for schizophrenia: a critical review of pharmacology and mechanisms of action of antipsychotic drugs.Development of allosteric modulators of GPCRs for treatment of CNS disorders Opportunities and challenges in the discovery of allosteric modulators of GPCRs for treating CNS disorders.N-desmethylclozapine, a major metabolite of clozapine, increases cortical acetylcholine and dopamine release in vivo via stimulation of M1 muscarinic receptors.SSR180711, a novel selective alpha7 nicotinic receptor partial agonist: (II) efficacy in experimental models predictive of activity against cognitive symptoms of schizophrenia.

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N-desmethylclozapine, an allosteric agonist at muscarinic 1 receptor, potentiates N-methyl-D-aspartate receptor activity.

http://www.wikidata.org/entity/Q37089832

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article científic

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bilimsel makale

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scientific article published on 31 October 2003

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vedecký článok

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vetenskaplig artikel

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vědecký článek

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name

N-desmethylclozapine, an allos ...... D-aspartate receptor activity.

@en

N-desmethylclozapine, an allos ...... D-aspartate receptor activity.

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type

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N-desmethylclozapine, an allos ...... D-aspartate receptor activity.

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N-desmethylclozapine, an allos ...... D-aspartate receptor activity.

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N-desmethylclozapine, an allos ...... D-aspartate receptor activity.

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N-desmethylclozapine, an allos ...... D-aspartate receptor activity.

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PNAS.1835612100

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Proceedings of the National Academy of Sciences of the United States of America

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N-desmethylclozapine, an allos ...... D-aspartate receptor activity.

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Cyrille Sur

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Danette Pascarella

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Douglas J Pettibone

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Edward M Scolnick

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Jacinta B Williams

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Marion Wittmann

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Marlene A Jacobson

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Philip E Brandish

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Pierre J Mallorga

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P2860

Antagonism by antimuscarinic and neuroleptic compounds at the five cloned human muscarinic cholinergic receptors expressed in Chinese hamster ovary cells

Hyperactivity, elevated dopaminergic transmission, and response to amphetamine in M1 muscarinic acetylcholine receptor-deficient mice

Effects of xanomeline, a selective muscarinic receptor agonist, on cognitive function and behavioral symptoms in Alzheimer disease.

Simultaneous determination of clozapine and its N-desmethyl and N-oxide metabolites in plasma by liquid chromatography/electrospray tandem mass spectrometry and its application to plasma level monitoring in schizophrenic patients.

The effects of clozapine, risperidone, and olanzapine on cognitive function in schizophrenia.

Clozapine for the treatment-resistant schizophrenic. A double-blind comparison with chlorpromazine.

Allosteric binding sites on cell-surface receptors: novel targets for drug discovery.

Glutamatergic mechanisms in schizophrenia.

Clozapine is a potent and selective muscarinic M4 receptor agonist.

Dopamine receptor sequences. Therapeutic levels of neuroleptics occupy D2 receptors, clozapine occupies D4.

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