Enediyne anticancer antibiotic lidamycin: chemistry, biology and pharmacology.
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Radio-frequency ablation-based studies on VX2rabbit models for HCC treatment.Role of sgcR3 in positive regulation of enediyne antibiotic C-1027 production of Streptomyces globisporus C-1027A bispecific enediyne-energized fusion protein targeting both epidermal growth factor receptor and insulin-like growth factor 1 receptor showing enhanced antitumor efficacy against non-small cell lung cancerImprovement of the enediyne antitumor antibiotic C-1027 production by manipulating its biosynthetic pathway regulation in Streptomyces globisporusSimultaneous determination of lidamycin enediyne chromophore (LDC) and its aromatized derivative (LDCA) using puerarin as internal standard in rat plasma by LC-MS/MS.Manipulation of pathway regulation in Streptomyces globisporus for overproduction of the enediyne antitumor antibiotic C-1027.Factor VII light chain-targeted lidamycin shows intensified therapeutic efficacy for liver cancer.Enediynes: Exploration of microbial genomics to discover new anticancer drug leads.Draft genome sequence of Streptomyces globisporus C-1027, which produces an antitumor antibiotic consisting of a nine-membered enediyne with a chromoprotein.Transarterial oily chemoembolization with lidamycin shows potent therapeutic efficacy in VX2 rabbit liver tumor.Site-specific PEGylation of lidamycin and its antitumor activity.Improvement of secondary metabolite production in Streptomyces by manipulating pathway regulationAn engineered TIMP2-based and enediyne-integrated fusion protein for targeting MMP-14 shows potent antitumor efficacy.Chloroquine potentiates the anti-cancer effect of lidamycin on non-small cell lung cancer cells in vitroSmall antibody fusion proteins with complementarity-determining regions and lidamycin for tumor targeting therapyThe novel structure make LDM effectively remove CD123+ AML stem cells in combination with interleukin 3.A free-standing condensation enzyme catalyzing ester bond formation in C-1027 biosynthesis.EZH2 mediates lidamycin-induced cellular senescence through regulating p21 expression in human colon cancer cells.Selective tumor killing based on specific DNA-damage response deficiencies.A CD13-targeting peptide integrated protein inhibits human liver cancer growth by killing cancer stem cells and suppressing angiogenesis.A novel antibody-drug conjugate anti-CD19(Fab)-LDM in the treatment of B-cell non-Hodgkin lymphoma xenografts with enhanced anticancer activity.A Gelatinases-targeting scFv-based Fusion Protein Shows Enhanced Antitumour Activity with Endostar against Hepatoma.Synergy of enediyne antibiotic lidamycin and temozolomide in suppressing glioma growth with potentiated apoptosis induction.Chemiluminescent detection of cell apoptosis enzyme by gold nanoparticle-based resonance energy transfer assay.Lidamycin up-regulates the expression of thymidine phosphorylase and enhances the effects of capecitabine on the growth and pulmonary metastases of murine breast carcinoma.Lidamycin inhibits tumor initiating cells of hepatocellular carcinoma Huh7 through GSK3β/β-catenin pathway.Antitumor effects of an engineered and energized fusion protein consisting of an anti-CD20 scFv fragment and lidamycin.A novel enediyne-integrated antibody-drug conjugate shows promising anti-tumor efficacy against CD30+ lymphomas.Ribosome engineering and fermentation optimization leads to overproduction of tiancimycin A, a new enediyne natural product from Streptomyces sp. CB03234.Lidamycin decreases CD133 expression in hepatocellular carcinoma via the Notch signaling pathway.An arginine-rich cell penetrating peptide contained anti-gelatinase scFv-LDM fusion protein shows potent antitumor efficacy in pancreatic cancer.Binding of a biosynthetic intermediate to AtrA modulates the production of lidamycin by Streptomyces globisporus.An arginine-rich cell penetrating peptide contained anti-gelatinase scFv-LDM fusion protein shows potent antitumor efficacy in pancreatic cancer.
P2860
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P2860
Enediyne anticancer antibiotic lidamycin: chemistry, biology and pharmacology.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on February 2008
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Enediyne anticancer antibiotic lidamycin: chemistry, biology and pharmacology.
@en
Enediyne anticancer antibiotic lidamycin: chemistry, biology and pharmacology.
@nl
type
label
Enediyne anticancer antibiotic lidamycin: chemistry, biology and pharmacology.
@en
Enediyne anticancer antibiotic lidamycin: chemistry, biology and pharmacology.
@nl
prefLabel
Enediyne anticancer antibiotic lidamycin: chemistry, biology and pharmacology.
@en
Enediyne anticancer antibiotic lidamycin: chemistry, biology and pharmacology.
@nl
P1476
Enediyne anticancer antibiotic lidamycin: chemistry, biology and pharmacology.
@en
P2093
Rong-guang Shao
Yong-su Zhen
P304
P356
10.2174/187152008783497055
P577
2008-02-01T00:00:00Z