Progranulin mutations as risk factors for Alzheimer disease - Wikidata - awgldk - TriplyDB

Progranulin mutations as risk factors for Alzheimer disease

Progranulin mutations as risk factors for Alzheimer disease

http://www.wikidata.org/entity/Q37095837

about

Progranulin directly binds to the CRD2 and CRD3 of TNFR extracellular domains Progranulin: at the interface of neurodegenerative and metabolic diseases Progranulin protects against amyloid β deposition and toxicity in Alzheimer's disease mouse models.Accumulation of multiple neurodegenerative disease-related proteins in familial frontotemporal lobar degeneration associated with granulin mutation.Assessment of amyloid β in pathologically confirmed frontotemporal dementia syndromes.Massive accumulation of luminal protease-deficient axonal lysosomes at Alzheimer's disease amyloid plaques Trehalose upregulates progranulin expression in human and mouse models of GRN haploinsufficiency: a novel therapeutic lead to treat frontotemporal dementia.Association Between Progranulin and Gaucher Disease.Amyloid in dementia associated with familial FTLD: not an innocent bystander.Frontotemporal Dementia and Psychiatric Illness: Emerging Clinical and Biological Links in Gene Carriers.Evaluating pathogenic dementia variants in posterior cortical atrophy.Screening of dementia genes by whole-exome sequencing in early-onset Alzheimer disease: input and lessons.Asymmetry and heterogeneity of Alzheimer's and frontotemporal pathology in primary progressive aphasia.C9ORF72 hexanucleotide repeats in behavioral and motor neuron disease: clinical heterogeneity and pathological diversity.Significance and limitation of the pathological classification of TDP-43 proteinopathy.The Role of PGRN in Alzheimer's Disease.Progranulin haploinsufficiency reduces amyloid beta deposition in Alzheimer's disease model mice.Progranulin, lysosomal regulation and neurodegenerative disease.Restoring neuronal progranulin reverses deficits in a mouse model of frontotemporal dementia.Opposing effects of progranulin deficiency on amyloid and tau pathologies via microglial TYROBP network.Early-Onset Alzheimer Disease and Candidate Risk Genes Involved in Endolysosomal Transport.Progranulin Protein Levels in Cerebrospinal Fluid in Primary Neurodegenerative Dementias.Association of progranulin polymorphism rs5848 with neurodegenerative diseases: a meta-analysis.Progranulin reduction is associated with increased tau phosphorylation in P301L tau transgenic mice.Commentary: Possible involvement of lysosomal dysfunction in pathological changes of the brain in aged progranulin-deficient mice The Progranulin Cleavage Products, Granulins, Exacerbate TDP-43 Toxicity and Increase TDP-43 Levels.Analysis of neurodegenerative Mendelian genes in clinically diagnosed Alzheimer Disease.Posterior cortical atrophy: a single case cognitive and radiological follow-up.Progranulin: a new avenue towards the understanding and treatment of neurodegenerative disease.Intranasal administration of recombinant progranulin inhibits bronchial smooth muscle hyperresponsiveness in mouse allergic asthma.Homer, Spikar, and Other Drebrin-Binding Proteins in the Brain.Alzheimer disease: modeling an Aβ-centered biological network.Trajectories of Multidimensional Caregiver Burden in Chinese Informal Caregivers for Dementia: Evidence from Exploratory and Confirmatory Factor Analysis of the Zarit Burden Interview.Progranulin protects against exaggerated axonal injury and astrogliosis following traumatic brain injury.Progranulin levels in blood in Alzheimer's disease and mild cognitive impairment.Whole-exome sequencing in 20,197 persons for rare variants in Alzheimer's disease.

P2860

Q24337327-65986C08-6B92-4C2A-9C44-7BD2549D05A0 Q27024421-61BA6647-8F3B-49E3-99BB-FC680595B7E1 Q30592224-849DF3DA-4C57-4815-911C-DFB6A6C87DD7 Q33685394-7350A65F-C6E0-4031-8E74-FFE6438D87BD Q33806930-8FE257AB-F936-4425-AF7B-55B9DBA4DB07 Q35865601-6348E93D-664B-4762-B599-C628C5B4DA28 Q36061223-4B7197E5-FC9D-41A8-A493-1F44733CEBFC Q36102138-98999DD0-52B5-4F39-813C-C155B1E2B10D Q36327682-9A641E0F-79C9-445F-BB46-22DB1BA76DD9 Q36391178-D31332EA-4D76-4F27-B1DD-952AE2AB84BE Q36396085-9E62BAFF-0305-4CCE-9B6A-4B310D7AFD17 Q37058503-7551E09C-50D0-4261-8FC2-34BE673D3024 Q37647791-F60AB87B-FC87-4990-A837-4A5DF9B66FAF Q38206207-68775513-AECB-43A0-A6C7-C6A7F91E8B98 Q38246772-3F8F45BD-FAF1-4262-8AD7-558E9AACD984 Q38555411-8CFF075F-4024-44A4-95D3-D1723D448A86 Q38606486-AEE6653B-56AA-44FE-8413-B0686E8E1D4A Q38691811-8B1EBF94-4DDB-44A5-AE41-BD5CB401AEA0 Q38853352-83646D26-3C47-422C-A801-8D91D3B7EEF9 Q39030129-B1308441-7D85-4B3C-918C-350C0AFBA4AE Q40110802-6E7CCDEB-1820-4597-BAC1-2434DC4BED2E Q40196222-81A1ECA8-2829-49C7-AFA9-AA2E38BC7CAF Q41595939-6A6E6EFE-DDA1-4533-876F-A269D89577B7 Q41600247-FBAD9D89-FD0A-4566-85E6-F00583D0A042 Q42041942-A838A829-011A-48D0-913D-1BAD2143E3B5 Q42410235-D554B3B0-77C7-4434-8FBF-8A8BDF33C42E Q46441393-AC89C038-CD80-4C0D-AFA5-2926C705EB5F Q47564180-75AFF416-EBF9-4645-8F10-70331BDB240D Q47623958-631865CE-09DE-4E0B-B83C-7D35D97D6C4A Q47690559-01A02746-C5FA-4F83-B5D3-509795279CB1 Q47866769-CE2434D9-AA76-4D97-B7CF-48A08C5F0592 Q47878052-77503282-7EB6-4242-A4AA-82E532CC7F1E Q48172464-1A2A07ED-4751-4343-B925-5A404CE036DF Q48460212-63CCD72E-0D43-433F-BDAB-5FD07B2E3D05 Q55259033-639EF5C7-F20B-4981-80E1-E7CD83308505 Q55691990-E21C0DBC-F5E1-46D0-BE16-8F91FD626D68

P2860

Progranulin mutations as risk factors for Alzheimer disease

http://www.wikidata.org/entity/Q37095837

description

article científic

@ca

article scientifique

@fr

articolo scientifico

@it

artigo científico

@pt

bilimsel makale

@tr

scientific article published on June 2013

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

Progranulin mutations as risk factors for Alzheimer disease

@en

Progranulin mutations as risk factors for Alzheimer disease.

@nl

type

label

Progranulin mutations as risk factors for Alzheimer disease

@en

Progranulin mutations as risk factors for Alzheimer disease.

@nl

prefLabel

Progranulin mutations as risk factors for Alzheimer disease

@en

Progranulin mutations as risk factors for Alzheimer disease.

@nl

P1433

Q37095837-7BC8FEE2-E53D-42A7-B1A1-C5708E76373F

P1476

Q37095837-AD549C2B-F331-4283-9CB5-7E60BC74DAE9

P2093

Q37095837-4D5F6511-54FD-41B3-8CBB-3AA9FF4F4F2D

Q37095837-503D9156-B9E0-4E10-9899-A4731A7F4D58

Q37095837-763A9619-FB16-40EC-80A7-F5F0B374FAD8

Q37095837-7BC41F86-E01E-4DDE-9342-2E943536900F

Q37095837-91C177DF-7C72-4B21-8275-B35666734A6F

Q37095837-BB7E1397-9B91-4391-8BBB-E28AF5BB2C87

Q37095837-D95E4BEF-7CF0-439C-A601-F38622D17A3F

Q37095837-DA90CE3A-60D5-4D1B-9008-A3EC66D7041F

Q37095837-DA955807-B2C8-4146-AA82-38EA599126D1

P2860

Q37095837-0680885D-801E-4C9D-931D-ABF1296C7C7B

Q37095837-1E155341-7998-43C7-9C16-DAB0E2A41BD0

Q37095837-2BD705E5-5112-4718-9F0B-EEACD9C7F982

Q37095837-35B1BF84-C605-45B3-848C-8CC99E53A083

Q37095837-3991B785-3232-4A47-AFB5-84E402EFF4CB

Q37095837-3FF7D1BC-FDA0-4D94-9A26-F5C30E33E8D3

Q37095837-433BC3C5-DB95-4C00-89BD-A0EB7A4AA2FA

Q37095837-47AAC80C-E262-42BA-9E5C-4ECCA1C5A221

Q37095837-4A85DFEA-8C39-403A-86BD-9C5CC308C06C

Q37095837-5ABB9364-8525-4138-90D8-FEE10392DA13

P304

Q37095837-D23B8BCB-2C23-4F0E-833E-B2AD19AC3943

P31

Q37095837-A5D81286-CBB2-4ABC-97F7-8C10BB27FD08

P356

Q37095837-19F9079F-A427-4A7F-861C-E7464B308BE6

P407

Q37095837-88FF79AB-9283-4B13-8402-4F8730F9343C

P433

Q37095837-1BB34B8D-E8CD-4997-9E65-EC967014A866

P478

Q37095837-4128402E-081E-4ABF-9861-E06C55B571D0

P50

Q37095837-B77D60F5-6929-4862-BF17-AB94F2D0ED6E

Q37095837-B97C4696-C2CF-400E-9255-DEB750619075

Q37095837-C4565F95-C9EA-4242-A788-57A13E30D1C5

P577

Q37095837-AFDDFDF9-0ECB-4273-9514-DB2DBFBFDE94

P5875

Q37095837-280C2521-BEDB-4E83-9F5E-6CC546108885

P698

Q37095837-6F4F5042-C675-4063-AA08-397008777B4B

P921

Q37095837-95E95E44-FE0F-4C5F-8C00-4AB1E0F442C4

P932

Q37095837-78CB08EB-F3DF-4A9A-A1DA-F0B9E0F78D4D

P356

2013.JAMANEUROL.393

P1433

P1476

Progranulin mutations as risk factors for Alzheimer disease

@en

P2093

Anna Karydas

http://www.w3.org/2001/XMLSchema#string

Dan Geschwind

http://www.w3.org/2001/XMLSchema#string

David C Perry

http://www.w3.org/2001/XMLSchema#string

Giovanni Coppola

http://www.w3.org/2001/XMLSchema#string

Howard Rosen

http://www.w3.org/2001/XMLSchema#string

Jason Jiyong Lee

http://www.w3.org/2001/XMLSchema#string

Jennifer S Yokoyama

http://www.w3.org/2001/XMLSchema#string

Lea T Grinberg

http://www.w3.org/2001/XMLSchema#string

Manja Lehmann

http://www.w3.org/2001/XMLSchema#string

P2860

A harmonized classification system for FTLD-TDP pathology

“Mini-mental state”

Potential mechanisms of progranulin-deficient FTLD

Neuropathological stageing of Alzheimer-related changes

Voxel-based morphometry--the methods

A fast diffeomorphic image registration algorithm

Exaggerated inflammation, impaired host defense, and neuropathology in progranulin-deficient mice

APOE predicts amyloid-beta but not tau Alzheimer pathology in cognitively normal aging.

Rs5848 variant influences GRN mRNA levels in brain and peripheral mononuclear cells in patients with Alzheimer's disease.

Systemic inflammation and disease progression in Alzheimer disease.

P304

774-778

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1001/2013.JAMANEUROL.393

http://www.w3.org/2001/XMLSchema#string

P407

P433

6

http://www.w3.org/2001/XMLSchema#string

P478

70

http://www.w3.org/2001/XMLSchema#string

P50

Bruce L. Miller

Gil D Rabinovici

P577

2013-06-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

236266937

http://www.w3.org/2001/XMLSchema#string

P698

23609919

http://www.w3.org/2001/XMLSchema#string

P921

Alzheimer's disease

P932

3743672

http://www.w3.org/2001/XMLSchema#string