mTOR couples cellular nutrient sensing to organismal metabolic homeostasis - Wikidata - awgldk - TriplyDB

mTOR couples cellular nutrient sensing to organismal metabolic homeostasis

mTOR couples cellular nutrient sensing to organismal metabolic homeostasis

http://www.wikidata.org/entity/Q37097444

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PI3K: An Attractive Candidate for the Central Integration of Metabolism and Reproduction Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1 Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1 Juvenile Hormone Biosynthesis in Insects: What Is New, What Do We Know, and What Questions Remain?The mTOR pathway in obesity driven gastrointestinal cancers: Potential targets and clinical trials The Macrophage Switch in Obesity Development Control of macrophage metabolism and activation by mTOR and Akt signaling A possible link between BDNF and mTOR in control of food intake Simple sugar intake and hepatocellular carcinoma: epidemiological and mechanistic insight Regulation of mTORC1 by PI3K signaling Amino acid sensing in dietary-restriction-mediated longevity: roles of signal-transducing kinases GCN2 and TOR Nocturnin: at the crossroads of clocks and metabolism Nutrient regulation of the mTOR complex 1 signaling pathway Loss of FTO antagonises Wnt signaling and leads to developmental defects associated with ciliopathies Stress responses from the endoplasmic reticulum in cancer Akt stimulates hepatic SREBP1c and lipogenesis through parallel mTORC1-dependent and independent pathways The TSC complex is required for the benefits of dietary protein restriction on stress resistance in vivo Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2 Involvement of mTOR in Type 2 CRF Receptor Inhibition of Insulin Signaling in Muscle Cells.Novel role for SHP-2 in nutrient-responsive control of S6 kinase 1 signaling.Transcriptional control of hepatic lipid metabolism by SREBP and ChREBP.Inhibition of ERK1/2 Restores GSK3β Activity and Protein Synthesis Levels in a Model of Tuberous Sclerosis.Regulation of blood-testis barrier (BTB) dynamics during spermatogenesis via the "Yin" and "Yang" effects of mammalian target of rapamycin complex 1 (mTORC1) and mTORC2.Insulin-like peptides and the target of rapamycin pathway coordinately regulate blood digestion and egg maturation in the mosquito Aedes aegypti.Postnatal changes in the expression pattern of the imprinted signalling protein XLαs underlie the changing phenotype of deficient mice.Akt-dependent activation of mTORC1 complex involves phosphorylation of mTOR (mammalian target of rapamycin) by IκB kinase α (IKKα).A two-way street: reciprocal regulation of metabolism and signalling.Protein partners of KCTD proteins provide insights about their functional roles in cell differentiation and vertebrate development.FOXO3-mTOR metabolic cooperation in the regulation of erythroid cell maturation and homeostasis.Sestrins orchestrate cellular metabolism to attenuate aging.The role of genomic imprinting in biology and disease: an expanding view.HDAC1 and HDAC2 restrain the intestinal inflammatory response by regulating intestinal epithelial cell differentiation.Essential amino acid enriched high-protein enteral nutrition modulates insulin-like growth factor-1 system function in a rat model of trauma-hemorrhagic shock.Lysosomal two-pore channel subtype 2 (TPC2) regulates skeletal muscle autophagic signaling.Ursolic acid inhibits leucine-stimulated mTORC1 signaling by suppressing mTOR localization to lysosome Transcriptome sequencing and positive selected genes analysis of Bombyx mandarina β-hydroxybutyrate: much more than a metabolite Intermittent bolus feeding has a greater stimulatory effect on protein synthesis in skeletal muscle than continuous feeding in neonatal pigs.MondoA senses adenine nucleotides: transcriptional induction of thioredoxin-interacting protein Insulin exerts direct, IGF-1 independent actions in growth plate chondrocytes.

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mTOR couples cellular nutrient sensing to organismal metabolic homeostasis

http://www.wikidata.org/entity/Q37097444

description

article científic

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article scientifique

@fr

articolo scientifico

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artigo científico

@pt

bilimsel makale

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scientific article published on 25 January 2011

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

mTOR couples cellular nutrient sensing to organismal metabolic homeostasis

@en

mTOR couples cellular nutrient sensing to organismal metabolic homeostasis.

@nl

type

label

mTOR couples cellular nutrient sensing to organismal metabolic homeostasis

@en

mTOR couples cellular nutrient sensing to organismal metabolic homeostasis.

@nl

prefLabel

mTOR couples cellular nutrient sensing to organismal metabolic homeostasis

@en

mTOR couples cellular nutrient sensing to organismal metabolic homeostasis.

@nl

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J.TEM.2010.12.003

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Trends in Endocrinology and Metabolism

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mTOR couples cellular nutrient sensing to organismal metabolic homeostasis

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Brendan D Manning

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Jessica J Howell

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P2860

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids

SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth

The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1

Upregulation of the mammalian target of rapamycin complex 1 pathway by Ras homolog enriched in brain in pancreatic beta-cells leads to increased beta-cell mass and prevention of hyperglycemia

Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1

Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling

mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)

AMPK phosphorylation of raptor mediates a metabolic checkpoint

Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation

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94-102

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scholarly article

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10.1016/J.TEM.2010.12.003

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3

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22

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2011-01-25T00:00:00Z

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21269838

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3744367

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