SIRT1 exerts anti-inflammatory effects and improves insulin sensitivity in adipocytes. - Wikidata - awgldk - TriplyDB

SIRT1 exerts anti-inflammatory effects and improves insulin sensitivity in adipocytes.

SIRT1 exerts anti-inflammatory effects and improves insulin sensitivity in adipocytes.

http://www.wikidata.org/entity/Q37099936

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SIRT1 activation by small molecules: kinetic and biophysical evidence for direct interaction of enzyme and activator SRT1720 improves survival and healthspan of obese mice In Search of New Therapeutic Targets in Obesity Treatment: Sirtuins New Therapeutic Concept of NAD Redox Balance for Cisplatin Nephrotoxicity Obestatin: a new metabolic player in the pancreas and white adipose tissue Sirtuin 1 and sirtuin 3: physiological modulators of metabolism Targeting sirtuin 1 to improve metabolism: all you need is NAD(+)?T cell replicative senescence in human aging MicroRNA 132 regulates nutritional stress-induced chemokine production through repression of SirT1 Sirtuin deacylases: a molecular link between metabolism and immunity SIRT1 activators suppress inflammatory responses through promotion of p65 deacetylation and inhibition of NF-κB activity Role of SIRT1 in regulation of LPS- or two ethanol metabolites-induced TNF-alpha production in cultured macrophage cell lines G protein-coupled receptor 21 deletion improves insulin sensitivity in diet-induced obese mice Mammalian sirtuins: biological insights and disease relevance 'Adipaging': ageing and obesity share biological hallmarks related to a dysfunctional adipose tissue.Augmentation of NAD(+) by NQO1 attenuates cisplatin-mediated hearing impairment.Optimal therapy of type 2 diabetes: a controversial challenge Small-molecule allosteric activators of sirtuins.Circadian rhythms and metabolic syndrome: from experimental genetics to human disease.SIRT1 inhibits inflammatory pathways in macrophages and modulates insulin sensitivity.Diabetes mellitus: channeling care through cellular discovery AMPK and SIRT1: a long-standing partnership?Adipose tissue NAD+ biology in obesity and insulin resistance: From mechanism to therapy A new antidiabetic compound attenuates inflammation and insulin resistance in Zucker diabetic fatty rats.Gene-chip studies of adipogenesis-regulated microRNAs in mouse primary adipocytes and human obesity.Early apoptotic vascular signaling is determined by Sirt1 through nuclear shuttling, forkhead trafficking, bad, and mitochondrial caspase activation.Macrophage alpha1 AMP-activated protein kinase (alpha1AMPK) antagonizes fatty acid-induced inflammation through SIRT1 Sirtinol treatment reduces inflammation in human dermal microvascular endothelial cells Myeloid deletion of SIRT1 induces inflammatory signaling in response to environmental stress.Knock-down of IL-1Ra in obese mice decreases liver inflammation and improves insulin sensitivity.Elevated microRNA-34a in obesity reduces NAD+ levels and SIRT1 activity by directly targeting NAMPT.The full capacity of AICAR to reduce obesity-induced inflammation and insulin resistance requires myeloid SIRT1 Novel avenues of drug discovery and biomarkers for diabetes mellitus.Combinatorial regulation of a signal-dependent activator by phosphorylation and acetylation.Decreased AMP-activated protein kinase activity is associated with increased inflammation in visceral adipose tissue and with whole-body insulin resistance in morbidly obese humans.The SIRT1 activator SRT1720 reverses vascular endothelial dysfunction, excessive superoxide production, and inflammation with aging in mice Hypothalamic microinflammation: a common basis of metabolic syndrome and aging.Resveratrol modifies risk factors for coronary artery disease in swine with metabolic syndrome and myocardial ischemia Restriction of advanced glycation end products improves insulin resistance in human type 2 diabetes: potential role of AGER1 and SIRT1 Sirtuin-1 regulation of mammalian metabolism

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P2860

SIRT1 exerts anti-inflammatory effects and improves insulin sensitivity in adipocytes.

http://www.wikidata.org/entity/Q37099936

description

article científic

@ca

article scientifique

@fr

articolo scientifico

@it

artigo científico

@pt

bilimsel makale

@tr

scientific article published on 22 December 2008

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

SIRT1 exerts anti-inflammatory effects and improves insulin sensitivity in adipocytes.

@en

SIRT1 exerts anti-inflammatory effects and improves insulin sensitivity in adipocytes.

@nl

type

label

SIRT1 exerts anti-inflammatory effects and improves insulin sensitivity in adipocytes.

@en

SIRT1 exerts anti-inflammatory effects and improves insulin sensitivity in adipocytes.

@nl

prefLabel

SIRT1 exerts anti-inflammatory effects and improves insulin sensitivity in adipocytes.

@en

SIRT1 exerts anti-inflammatory effects and improves insulin sensitivity in adipocytes.

@nl

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P1433

Molecular and Cellular Biology

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SIRT1 exerts anti-inflammatory effects and improves insulin sensitivity in adipocytes.

@en

P2093

Jennie L Babendure

http://www.w3.org/2001/XMLSchema#string

Jesse J Smith

http://www.w3.org/2001/XMLSchema#string

Jill C Milne

http://www.w3.org/2001/XMLSchema#string

Juu-Chin Lu

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Michael R Jirousek

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Noriyuki Sonoda

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Simon Schenk

http://www.w3.org/2001/XMLSchema#string

Takeshi Imamura

http://www.w3.org/2001/XMLSchema#string

Takeshi Yoshizaki

http://www.w3.org/2001/XMLSchema#string

P2860

Inflammation and insulin resistance

Negative control of p53 by Sir2alpha promotes cell survival under stress

hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase

Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase.

Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma

Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase

SIRT1 deacetylates and positively regulates the nuclear receptor LXR

Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance

Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes

Resveratrol improves health and survival of mice on a high-calorie diet

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1363-1374

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scholarly article

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10.1128/MCB.00705-08

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P407

P433

5

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29

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Jerrold M. Olefsky

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2008-12-22T00:00:00Z

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19103747

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2643824

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