The Psi(m) depolarization that accompanies mitochondrial Ca2+ uptake is greater in mutant SOD1 than in wild-type mouse motor terminals.
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The mitochondrial Ca2+ uniporter MCU is essential for glucose-induced ATP increases in pancreatic β-cellsImpaired Autophagy and Defective Mitochondrial Function: Converging Paths on the Road to Motor Neuron DegenerationALS Patient Stem Cells for Unveiling Disease Signatures of Motoneuron Susceptibility: Perspectives on the Deadly Mitochondria, ER Stress and Calcium TriadMitochondria in motor nerve terminals: function in health and in mutant superoxide dismutase 1 mouse models of familial ALSMitochondrial calcium uptake underlies ROS generation during aminoglycoside-induced hair cell deathHyperactive intracellular calcium signaling associated with localized mitochondrial defects in skeletal muscle of an animal model of amyotrophic lateral sclerosisER-mitochondrial calcium flow underlies vulnerability of mechanosensory hair cells to damage.ALS-linked mutant SOD1 damages mitochondria by promoting conformational changes in Bcl-2.Mitochondrial pathobiology in ALS.Mitochondrial dysfunction and intracellular calcium dysregulation in ALSMisfolded mutant SOD1 directly inhibits VDAC1 conductance in a mouse model of inherited ALSMitochondrial and Cell Death Mechanisms in Neurodegenerative Diseases.Repetitive nerve stimulation transiently opens the mitochondrial permeability transition pore in motor nerve terminals of symptomatic mutant SOD1 miceEarly changes of neuromuscular transmission in the SOD1(G93A) mice model of ALS start long before motor symptoms onsetIncreased axonal mitochondrial mobility does not slow amyotrophic lateral sclerosis (ALS)-like disease in mutant SOD1 mice.Activity-dependent degeneration of axotomized neuromuscular synapses in Wld S mice.Comparison of dendritic calcium transients in juvenile wild type and SOD1(G93A) mouse lumbar motoneurons.Elevated mRNA-levels of distinct mitochondrial and plasma membrane Ca(2+) transporters in individual hypoglossal motor neurons of endstage SOD1 transgenic mice.Gender-Specific Mechanism of Synaptic Impairment and Its Prevention by GCSF in a Mouse Model of ALS.An approach to experimental synaptic pathology using green fluorescent protein-transgenic mice and gene knockout mice to show mitochondrial permeability transition pore-driven excitotoxicity in interneurons and motoneuronsBiology of mitochondria in neurodegenerative diseases.Mitochondrial dynamics and bioenergetic dysfunction is associated with synaptic alterations in mutant SOD1 motor neurons.Pre-symptomatic detection of chronic motor deficits and genotype prediction in congenic B6.SOD1(G93A) ALS mouse model.The mitochondrial permeability transition pore: a molecular target for amyotrophic lateral sclerosis therapy.Insulin and Insulin-Sensitizing Drugs in Neurodegeneration: Mitochondria as Therapeutic Targets.Review: The role of mitochondria in the pathogenesis of amyotrophic lateral sclerosis.Mitochondrial dysfunction in familial amyotrophic lateral sclerosis.Selective mitochondrial Ca2+ uptake deficit in disease endstage vulnerable motoneurons of the SOD1G93A mouse model of amyotrophic lateral sclerosis.Mutant SOD1 and mitochondrial damage alter expression and splicing of genes controlling neuritogenesis in models of neurodegeneration.Dysfunctional mitochondrial Ca(2+) handling in mutant SOD1 mouse models of fALS: integration of findings from motor neuron somata and motor terminalsSOD1 and MitoTEMPO partially prevent mitochondrial permeability transition pore opening, necrosis, and mitochondrial apoptosis after ATP depletion recovery.Vesicular ATPase inserted into the plasma membrane of motor terminals by exocytosis alkalinizes cytosolic pH and facilitates endocytosis.Links between electrophysiological and molecular pathology of amyotrophic lateral sclerosis.Platform CommunicationsExcitatory Dendritic Mitochondrial Calcium Toxicity: Implications for Parkinson's and Other Neurodegenerative Diseases
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The Psi(m) depolarization that accompanies mitochondrial Ca2+ uptake is greater in mutant SOD1 than in wild-type mouse motor terminals.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
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artigo científico
@pt
bilimsel makale
@tr
scientific article published on 27 January 2009
@en
vedecký článok
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vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
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name
The Psi
@nl
The Psi(m) depolarization that ...... ld-type mouse motor terminals.
@en
type
label
The Psi
@nl
The Psi(m) depolarization that ...... ld-type mouse motor terminals.
@en
prefLabel
The Psi
@nl
The Psi(m) depolarization that ...... ld-type mouse motor terminals.
@en
P2093
P2860
P356
P1476
The Psi(m) depolarization that ...... ild-type mouse motor terminals
@en
P2093
Ellen F Barrett
John N Barrett
Khanh T Nguyen
Luis E García-Chacón
P2860
P304
P356
10.1073/PNAS.0810934106
P407
P577
2009-01-27T00:00:00Z