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Accumulation of neutral lipids in peripheral blood mononuclear cells as a distinctive trait of Alzheimer patients and asymptomatic subjects at risk of diseaseACAT1 gene ablation increases 24(S)-hydroxycholesterol content in the brain and ameliorates amyloid pathology in mice with AD.Elevated stearoyl-CoA desaturase in brains of patients with Alzheimer's disease.Inhibition of Acyl-CoA: cholesterol acyltransferase (ACAT), overexpression of cholesterol transporter gene, and protection of amyloid β (Aβ) oligomers-induced neuronal cell death by tricyclic pyrone moleculesDesign, synthesis, and evaluation of bioactive small molecules.Changes in cholesterol metabolism-related gene expression in peripheral blood mononuclear cells from Alzheimer patients.ACAT1 regulates the dynamics of free cholesterols in plasma membrane which leads to the APP-α-processing alteration.Potentiating the antitumour response of CD8(+) T cells by modulating cholesterol metabolismAcyl-coenzyme A:cholesterol acyltransferases.Microdomains, Inflammation, and Atherosclerosis.Chemical Genetic Approaches for the Investigation of Neutral Lipid Metabolism.
P2860
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P2860
description
article científic
@ca
article scientifique
@fr
articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 06 March 2008
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
@cs
name
ACAT as a drug target for Alzheimer's disease
@en
ACAT as a drug target for Alzheimer's disease.
@nl
type
label
ACAT as a drug target for Alzheimer's disease
@en
ACAT as a drug target for Alzheimer's disease.
@nl
prefLabel
ACAT as a drug target for Alzheimer's disease
@en
ACAT as a drug target for Alzheimer's disease.
@nl
P2860
P356
P1476
ACAT as a drug target for Alzheimer's disease
@en
P2093
Dora M Kovacs
P2860
P304
P356
10.1159/000113705
P577
2008-03-06T00:00:00Z