An intestinal epithelium-specific cytochrome P450 (P450) reductase-knockout mouse model: direct evidence for a role of intestinal p450s in first-pass clearance of oral nifedipine.
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An update on the role of intestinal cytochrome P450 enzymes in drug dispositionNeurobehavioral abnormalities in a brain-specific NADPH-cytochrome P450 reductase knockout mouse modelMice deficient in intestinal epithelium cytochrome P450 reductase are prone to acute toxin-induced mucosal damage.The role of small-intestinal P450 enzymes in protection against systemic exposure of orally administered benzo[a]pyreneAdaptive hepatic and intestinal alterations in mice after deletion of NADPH-cytochrome P450 Oxidoreductase (Cpr) in hepatocytesRole of hepatic and intestinal p450 enzymes in the metabolic activation of the colon carcinogen azoxymethane in mice.Identification of cytochrome P450 enzymes critical for lung tumorigenesis by the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK): insights from a novel Cyp2abfgs-null mouseDrug-metabolizing enzyme, transporter, and nuclear receptor genetically modified mouse models.Role of intestinal cytochrome P450 (P450) in modulating the bioavailability of oral lovastatin: insights from studies on the intestinal epithelium-specific P450 reductase knockout mouse.Conditional deletion of cytochrome p450 reductase in osteoprogenitor cells affects long bone and skull development in mice recapitulating antley-bixler syndrome: role of a redox enzyme in development.Identification of cytochrome P450 oxidoreductase gene variants that are significantly associated with the interindividual variations in warfarin maintenance dose.Intestinal epithelium-specific knockout of the cytochrome P450 reductase gene exacerbates dextran sulfate sodium-induced colitisPotential biological functions of cytochrome P450 reductase-dependent enzymes in small intestine: novel link to expression of major histocompatibility complex class II genes.Role of intestinal cytochrome p450 enzymes in diclofenac-induced toxicity in the small intestine.Effect of Cytochrome P450 Reductase Deficiency on 2-Amino-9H-pyrido[2,3-b]indole Metabolism and DNA Adduct Formation in Liver and Extrahepatic Tissues of Mice.Generation and characterization of a novel Cyp2a(4/5)bgs-null mouse modelNADPH-cytochrome P450 oxidoreductase: roles in physiology, pharmacology, and toxicology.Dietary regulation of mouse intestinal P450 expression and drug metabolismGastrointestinal and hepatotoxicity assessment of an anticancer extract from muricid molluscs.Role of mammary epithelial and stromal P450 enzymes in the clearance and metabolic activation of 7,12-dimethylbenz(a)anthracene in mice.The role of renal proximal tubule P450 enzymes in chloroform-induced nephrotoxicity: utility of renal specific P450 reductase knockout mouse models.Regulation of intestinal cytochrome P450 expression by hepatic cytochrome P450: possible involvement of fibroblast growth factor 15 and impact on systemic drug exposure.In vitro and in vivo small intestinal metabolism of CYP3A and UGT substrates in preclinical animals species and humans: species differences.Dealing with the complex drug-drug interactions: towards mechanistic models.Physiologically based pharmacokinetic modeling revealed minimal codeine intestinal metabolism in first-pass removal in rats.Metabolite Kinetics: The Segregated Flow Model for Intestinal and Whole Body Physiologically Based Pharmacokinetic Modeling to Describe Intestinal and Hepatic Glucuronidation of Morphine in Rats In Vivo.Application of a novel regulatable Cre recombinase system to define the role of liver and gut metabolism in drug oral bioavailability.
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An intestinal epithelium-specific cytochrome P450 (P450) reductase-knockout mouse model: direct evidence for a role of intestinal p450s in first-pass clearance of oral nifedipine.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 04 December 2008
@en
vedecký článok
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vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
An intestinal epithelium-speci ...... clearance of oral nifedipine.
@en
An intestinal epithelium-specific cytochrome P450
@nl
type
label
An intestinal epithelium-speci ...... clearance of oral nifedipine.
@en
An intestinal epithelium-specific cytochrome P450
@nl
prefLabel
An intestinal epithelium-speci ...... clearance of oral nifedipine.
@en
An intestinal epithelium-specific cytochrome P450
@nl
P2093
P2860
P356
P1476
An intestinal epithelium-speci ...... clearance of oral nifedipine.
@en
P2093
Cheng Fang
Deborah Dunbar
Laurence Kaminsky
Qing-Yu Zhang
Xinxin Ding
P2860
P304
P356
10.1124/DMD.108.025429
P577
2008-12-04T00:00:00Z