JAK2 inhibition sensitizes resistant EGFR-mutant lung adenocarcinoma to tyrosine kinase inhibitors
about
A novel, somatic, transforming mutation in the extracellular domain of Epidermal Growth Factor Receptor identified in myeloproliferative neoplasm.Preclinical development of G1T38: A novel, potent and selective inhibitor of cyclin dependent kinases 4/6 for use as an oral antineoplastic in patients with CDK4/6 sensitive tumors.Genetic defects of the IRF1-mediated major histocompatibility complex class I antigen presentation pathway occur prevalently in the JAK2 gene in non-small cell lung cancer.Understanding and targeting resistance mechanisms in NSCLC.EGFR feedback-inhibition by Ran-binding protein 6 is disrupted in cancer.Development of Erasin: a chromone-based STAT3 inhibitor which induces apoptosis in Erlotinib-resistant lung cancer cells.A Phase 1/2 Trial of Ruxolitinib and Erlotinib in Patients with EGFR-Mutant Lung Adenocarcinomas with Acquired Resistance to Erlotinib.Cancer gene profiling in non-small cell lung cancers reveals activating mutations in JAK2 and JAK3 with therapeutic implications.Activating mutation of PDGFRB gene in a rare cardiac undifferentiated intimal sarcoma of the left atrium: a case report.TRIM59 promotes gliomagenesis by inhibiting TC45 dephosphorylation of STAT3.Emerging application of genomics-guided therapeutics in personalized lung cancer treatment.
P2860
Q33732661-19DB0985-8726-41EC-B359-975A360E19D9Q38832541-91E9D3AF-085B-489D-A664-DB620B20DC8AQ42365255-E9842FF4-B7CA-4C96-9B71-4BC396A6F552Q46915997-F98E1689-FE3F-465C-9E07-03E8F5FC5B08Q47111538-0563E872-1DDF-4438-AE00-1B469A8467FFQ47122836-4DA1F38D-0CCA-4EBB-B07F-9A1F4166306CQ47126909-69CED024-5427-41CC-BC47-CA9869178503Q47151526-063D66DB-E43D-43CA-9A3D-66C834343D95Q47159879-1A592D3D-311F-40FD-A7E2-17F882BEEA12Q47828321-F7A26C68-16A6-42DF-B8E3-EC7DE1E310CEQ55314894-634A7AF9-40D6-45F5-B77F-6950AB909217
P2860
JAK2 inhibition sensitizes resistant EGFR-mutant lung adenocarcinoma to tyrosine kinase inhibitors
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 29 March 2016
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
JAK2 inhibition sensitizes res ...... to tyrosine kinase inhibitors
@en
JAK2 inhibition sensitizes res ...... to tyrosine kinase inhibitors.
@nl
type
label
JAK2 inhibition sensitizes res ...... to tyrosine kinase inhibitors
@en
JAK2 inhibition sensitizes res ...... to tyrosine kinase inhibitors.
@nl
prefLabel
JAK2 inhibition sensitizes res ...... to tyrosine kinase inhibitors
@en
JAK2 inhibition sensitizes res ...... to tyrosine kinase inhibitors.
@nl
P2093
P2860
P50
P1433
P1476
JAK2 inhibition sensitizes res ...... to tyrosine kinase inhibitors
@en
P2093
David Lyden
David Solit
Dennis Huszar
Eirini Bournazou
Erez Schori
Gregoire Altan-Bonnet
Haiying Zhang
Jacqueline F Bromberg
Katia Manova-Todorova
Laura A Daly
P2860
P356
10.1126/SCISIGNAL.AAC8460
P577
2016-03-29T00:00:00Z