c-di-GMP is an effective immunomodulator and vaccine adjuvant against pneumococcal infection.
about
Cyclic di-GMP: the first 25 years of a universal bacterial second messengerRationale, progress and development of vaccines utilizing STING-activating cyclic dinucleotide adjuvantsAntibiotics in Canadian poultry productions and anticipated alternativesImpairment of pneumococcal antigen specific isotype-switched Igg memory B-cell immunity in HIV infected Malawian adults.The mucosal adjuvant cyclic di-AMP exerts immune stimulatory effects on dendritic cells and macrophagesMPYS is required for IFN response factor 3 activation and type I IFN production in the response of cultured phagocytes to bacterial second messengers cyclic-di-AMP and cyclic-di-GMP.The mucosal adjuvant cyclic di-GMP enhances antigen uptake and selectively activates pinocytosis-efficient cells in vivo.Nanoparticulate STING agonists are potent lymph node-targeted vaccine adjuvants.Identification of a novel pneumococcal vaccine antigen preferentially expressed during meningitis in mice.Cyclic di-nucleotides: new era for small molecules as adjuvants.Biofilm infections, their resilience to therapy and innovative treatment strategies.Adjuvant immunotherapies as a novel approach to bacterial infections.Large-scale production of the immunomodulator c-di-GMP from GMP and ATP by an enzymatic cascade.Cyclic Dinucleotides in the Scope of the Mammalian Immune System.Stimulation of innate immunity by in vivo cyclic di-GMP synthesis using adenovirus.Identification and Characterization of Stimulator of Interferon Genes As a Robust Adjuvant Target for Early Life Immunization.STING-Activating Adjuvants Elicit a Th17 Immune Response and Protect against Mycobacterium tuberculosis Infection.Enhanced immunostimulatory activity of cyclic dinucleotides on mouse cells when complexed with a cell-penetrating peptide or combined with CpG.MPYS/STING-mediated TNF-α, not type I IFN, is essential for the mucosal adjuvant activity of (3'-5')-cyclic-di-guanosine-monophosphate in vivo.Identification and Characterization of c-di-GMP Metabolic Enzymes of Leptospira interrogans and c-di-GMP Fluctuations After Thermal Shift and Infection.Codon optimization and improved delivery/immunization regimen enhance the immune response against wild-type and drug-resistant HIV-1 reverse transcriptase, preserving its Th2-polarity.
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P2860
c-di-GMP is an effective immunomodulator and vaccine adjuvant against pneumococcal infection.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 18 July 2008
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
c-di-GMP is an effective immun ...... gainst pneumococcal infection.
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c-di-GMP is an effective immun ...... gainst pneumococcal infection.
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type
label
c-di-GMP is an effective immun ...... gainst pneumococcal infection.
@en
c-di-GMP is an effective immun ...... gainst pneumococcal infection.
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prefLabel
c-di-GMP is an effective immun ...... gainst pneumococcal infection.
@en
c-di-GMP is an effective immun ...... gainst pneumococcal infection.
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P2093
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P1433
P1476
c-di-GMP is an effective immun ...... against pneumococcal infection
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Alun C Kirby
David K R Karaolis
James C Paton
Yoshihiro Hayakawa
P2860
P304
P356
10.1016/J.VACCINE.2008.06.099
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P577
2008-07-18T00:00:00Z