Effects of glycosylation on the stability of protein pharmaceuticals.
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Site-specific functionalization of proteins and their applications to therapeutic antibodiesRoles for major histocompatibility complex glycosylation in immune functionGlycotherapy: new advances inspire a reemergence of glycans in medicineEngineering a Monomeric Fc Domain Modality by N-Glycosylation for the Half-life Extension of BiotherapeuticsStructural and Energetic Basis of Carbohydrate–Aromatic Packing Interactions in ProteinsEffects of Glycosylation on the Enzymatic Activity and Mechanisms of ProteasesGlycan analysis of therapeutic glycoproteinsGlycoengineering of interferon-β 1a improves its biophysical and pharmacokinetic propertiesGlycosylation variants of a β-glucosidase secreted by a Taiwanese fungus, Chaetomella raphigera, exhibit variant-specific catalytic and biochemical propertiesEffects of N-glycosylation on protein conformation and dynamics: Protein Data Bank analysis and molecular dynamics simulation study.Effect of distal sugar and interglycosidic linkage of disaccharides on the activity of proline rich antimicrobial glycopeptides.Glucosylglycerol and glucosylglycerate as enzyme stabilizers.Perturbing the folding energy landscape of the bacterial immunity protein Im7 by site-specific N-linked glycosylation.High-throughput biophysical analysis and data visualization of conformational stability of an IgG1 monoclonal antibody after deglycosylation.Glycosylation of therapeutic proteins: an effective strategy to optimize efficacyMoisture-induced solid state instabilities in alpha-chymotrypsin and their reduction through chemical glycosylation.Conformation and dynamics of biopharmaceuticals: transition of mass spectrometry-based tools from academe to industry.In vivo protein stabilization based on fragment complementation and a split GFP system.Quantitative investigation of human cell surface N-glycoprotein dynamics.Glycosylation, an effective synthetic strategy to improve the bioavailability of therapeutic peptides.Conformational and aggregation properties of a PEGylated alanine-rich polypeptideRecent application of analytical methods to phase I and phase II drugs development: a review.Chemical glycosylation of cytochrome c improves physical and chemical protein stability.Mass spectrometric characterization of human N-acylethanolamine-hydrolyzing acid amidase.Integrating bioinformatics tools to handle glycosylationIschemia-reperfusion injury of the retina is linked to necroptosis via the ERK1/2-RIP3 pathway.The intrinsic and extrinsic effects of N-linked glycans on glycoproteostasis.Activation of caspase-dependent apoptosis by intracellular delivery of Cytochrome c-based nanoparticles.Galactosyltransferase 4 is a major control point for glycan branching in N-linked glycosylation.Characterization and favorable in vivo properties of heterodimeric soluble IL-15·IL-15Rα cytokine compared to IL-15 monomer.Role of glycosylation in structure and stability of Erythrina corallodendron lectin (EcorL): a molecular dynamics study.Analysis of native and APTS-labeled N-glycans by capillary electrophoresis/time-of-flight mass spectrometry.Chemically glycosylation improves the stability of an amperometric horseradish peroxidase biosensorConvergent chemoenzymatic synthesis of a library of glycosylated analogues of pramlintide: structure-activity relationships for amylin receptor agonism.Regional brain [(11)C]carfentanil binding following tobacco smoking.Biochemical properties and structure analysis of a DAG-Like lipase from Malassezia globosa.Immuno-affinity purification of PglPGIP1, a polygalacturonase-inhibitor protein from pearl millet: studies on its inhibition of fungal polygalacturonases and role in resistance against the downy mildew pathogen.Longevity and GAPDH Stability in Bivalves and Mammals: A Convenient Marker for Comparative Gerontology and Proteostasis.An Engineered Version of Human PON2 Opens the Way to Understand the Role of Its Post-Translational Modifications in Modulating Catalytic Activity.Abnormal N-acetylglucosaminyltransferase expression in prefrontal cortex in schizophrenia.
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P2860
Effects of glycosylation on the stability of protein pharmaceuticals.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on April 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Effects of glycosylation on the stability of protein pharmaceuticals.
@en
Effects of glycosylation on the stability of protein pharmaceuticals.
@nl
type
label
Effects of glycosylation on the stability of protein pharmaceuticals.
@en
Effects of glycosylation on the stability of protein pharmaceuticals.
@nl
prefLabel
Effects of glycosylation on the stability of protein pharmaceuticals.
@en
Effects of glycosylation on the stability of protein pharmaceuticals.
@nl
P2860
P356
P1476
Effects of glycosylation on the stability of protein pharmaceuticals.
@en
P2093
Kai Griebenow
Ricardo J Solá
P2860
P304
P356
10.1002/JPS.21504
P407
P577
2009-04-01T00:00:00Z