Akt determines cell fate through inhibition of the PERK-eIF2α phosphorylation pathway - Wikidata - awgldk - TriplyDB

Akt determines cell fate through inhibition of the PERK-eIF2α phosphorylation pathway

Akt determines cell fate through inhibition of the PERK-eIF2α phosphorylation pathway

http://www.wikidata.org/entity/Q37119471

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Novel therapeutic strategies for multiple myeloma Eukaryotic initiation factor 2α--a downstream effector of mammalian target of rapamycin--modulates DNA repair and cancer response to treatment Modulation of the Akt pathway reveals a novel link with PERK/eIF2α, which is relevant during hypoxia Baclofen Protects Primary Rat Retinal Ganglion Cells from Chemical Hypoxia-Induced Apoptosis Through the Akt and PERK Pathways Regulation of NADPH-dependent Nitric Oxide and reactive oxygen species signalling in endothelial and melanoma cells by a photoactive NADPH analogue.Selective and potent Akt inhibition triggers anti-myeloma activities and enhances fatal endoplasmic reticulum stress induced by proteasome inhibition.An upstream open reading frame modulates ebola virus polymerase translation and virus replication.PERK silence inhibits glioma cell growth under low glucose stress by blockage of p-AKT and subsequent HK2's mitochondria translocation.3,3'-Diindolylmethane (DIM) and its ring-substituted halogenated analogs (ring-DIMs) induce differential mechanisms of survival and death in androgen-dependent and -independent prostate cancer cells.Endoplasmic reticulum stress, the unfolded protein response, autophagy, and the integrated regulation of breast cancer cell fate.Pdcd4 Is Involved in the Formation of Stress Granule in Response to Oxidized Low-Density Lipoprotein or High-Fat Diet.Panax quinquefolium saponin attenuates cardiomyocyte apoptosis induced by thapsigargin through inhibition of endoplasmic reticulum stress.Comparative transcriptomic analysis of silkworm Bmovo-1 and wild type silkworm ovary.The PERK-eIF2α phosphorylation arm is a pro-survival pathway of BCR-ABL signaling and confers resistance to imatinib treatment in chronic myeloid leukemia cells.Angiotensin II induces endoplasmic reticulum stress in podocyte, which would be further augmented by PI3-kinase inhibition ER stress potentiates insulin resistance through PERK-mediated FOXO phosphorylation.ATF4 induction through an atypical integrated stress response to ONC201 triggers p53-independent apoptosis in hematological malignancies.mTORC1 and CK2 coordinate ternary and eIF4F complex assembly.Total 4EBP1 Is Elevated in Liver of Rats in Response to Low Sulfur Amino Acid Intake.Disruption of Protein Processing in the Endoplasmic Reticulum of DYT1 Knock-in Mice Implicates Novel Pathways in Dystonia Pathogenesis.eIF2α phosphorylation bypasses premature senescence caused by oxidative stress and pro-oxidant antitumor therapies.High-refined-carbohydrate and high-fat diets induce comparable hepatic tumorigenesis in male mice.Post-transcriptional control of type I interferon induction by porcine reproductive and respiratory syndrome virus in its natural host cells.Control of oncogenesis by eIF2α phosphorylation: implications in PTEN and PI3K-Akt signaling and tumor treatment.Akt/PKB: one kinase, many modifications.Evidence for eIF2α phosphorylation-independent effects of GSK2656157, a novel catalytic inhibitor of PERK with clinical implications.Rescue of impaired sociability and anxiety-like behavior in adult cacna1c-deficient mice by pharmacologically targeting eIF2α.Molecular mechanisms of mTOR regulation by stress Suppression of PI3K/Akt signaling by synthetic bichalcone analog TSWU-CD4 induces ER stress- and Bax/Bak-mediated apoptosis of cancer cells.Fine-tuning PERK signaling for neuroprotection.The eIF2α serine 51 phosphorylation-ATF4 arm promotes HIPPO signaling and cell death under oxidative stress.Calcineurin β protects brain after injury by activating the unfolded protein response.[Pemetrexed + Sorafenib] lethality is increased by inhibition of ERBB1/2/3-PI3K-NFκB compensatory survival signaling.The histone deacetylase inhibitor romidepsin synergizes with lenalidomide and enhances tumor cell death in T-cell lymphoma cell lines.Phosphorylation of the translation initiation factor eIF2α at serine 51 determines the cell fate decisions of Akt in response to oxidative stress Residues required for phosphorylation of translation initiation factor eIF2α under diverse stress conditions are divergent between yeast and human.Moxibustion Activates Macrophage Autophagy and Protects Experimental Mice against Bacterial Infection.HIV-1 Gp120 clade B/C induces a GRP78 driven cytoprotective mechanism in astrocytoma.Complementary Roles of GADD34- and CReP-Containing Eukaryotic Initiation Factor 2α Phosphatases during the Unfolded Protein Response.Tumor progression locus 2 ablation suppressed hepatocellular carcinoma development by inhibiting hepatic inflammation and steatosis in mice

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Akt determines cell fate through inhibition of the PERK-eIF2α phosphorylation pathway

http://www.wikidata.org/entity/Q37119471

description

article científic

@ca

article scientifique

@fr

articolo scientifico

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artigo científico

@pt

bilimsel makale

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scientific article published on September 2011

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

Akt determines cell fate through inhibition of the PERK-eIF2α phosphorylation pathway

@en

Akt determines cell fate through inhibition of the PERK-eIF2α phosphorylation pathway.

@nl

type

label

Akt determines cell fate through inhibition of the PERK-eIF2α phosphorylation pathway

@en

Akt determines cell fate through inhibition of the PERK-eIF2α phosphorylation pathway.

@nl

prefLabel

Akt determines cell fate through inhibition of the PERK-eIF2α phosphorylation pathway

@en

Akt determines cell fate through inhibition of the PERK-eIF2α phosphorylation pathway.

@nl

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SCISIGNAL.2001630

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Science Signaling

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Akt determines cell fate through inhibition of the PERK-eIF2α phosphorylation pathway

@en

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Antonis E Koromilas

http://www.w3.org/2001/XMLSchema#string

Barbara Papadopoulou

http://www.w3.org/2001/XMLSchema#string

Jothi Latha Krishnamoorthy

http://www.w3.org/2001/XMLSchema#string

Maria Hatzoglou

http://www.w3.org/2001/XMLSchema#string

Shirley Campbell

http://www.w3.org/2001/XMLSchema#string

Shuo Wang

http://www.w3.org/2001/XMLSchema#string

William J Muller

http://www.w3.org/2001/XMLSchema#string

Zineb Mounir

http://www.w3.org/2001/XMLSchema#string

P2860

Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence

AKT/PKB signaling: navigating downstream

The identification of 2-(1H-indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (GDC-0941) as a potent, selective, orally bioavailable inhibitor of class I PI3 kinase for the treatment of cancer

Signal integration in the endoplasmic reticulum unfolded protein response

Regulation of translation initiation in eukaryotes: mechanisms and biological targets

Translational control is required for the unfolded protein response and in vivo glucose homeostasis

IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA

Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase

Heme-regulated eIF2alpha kinase (HRI) is required for translational regulation and survival of erythroid precursors in iron deficiency

A synthetic inhibitor of the mitogen-activated protein kinase cascade

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ra62

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scholarly article

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10.1126/SCISIGNAL.2001630

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192

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4

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2011-09-01T00:00:00Z

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21954288

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phosphorylation

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3752779

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