Cannabinoid receptor 2 signaling in peripheral immune cells modulates disease onset and severity in mouse models of Huntington's disease. - Wikidata - awgldk - TriplyDB

Cannabinoid receptor 2 signaling in peripheral immune cells modulates disease onset and severity in mouse models of Huntington's disease.

Cannabinoid receptor 2 signaling in peripheral immune cells modulates disease onset and severity in mouse models of Huntington's disease.

http://www.wikidata.org/entity/Q37120339

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The choreography of neuroinflammation in Huntington's disease Laquinimod rescues striatal, cortical and white matter pathology and results in modest behavioural improvements in the YAC128 model of Huntington disease.Neuroimmunology of Huntington's Disease: Revisiting Evidence from Human Studies Huntington’s disease blood and brain show a common gene expression pattern and share an immune signature with Alzheimer’s disease Mutant huntingtin impairs immune cell migration in Huntington disease.A scFv antibody targeting common oligomeric epitope has potential for treating several amyloidoses.Microglial Activation in the Pathogenesis of Huntington's Disease.Targets for future clinical trials in Huntington's disease: what's in the pipeline?Therapeutic advances in Huntington's Disease.The role of the immune system in triplet repeat expansion diseases Endocannabinoid signalling and the deteriorating brain Mutant Huntingtin Does Not Affect the Intrinsic Phenotype of Human Huntington's Disease T Lymphocytes.VCE-003.2, a novel cannabigerol derivative, enhances neuronal progenitor cell survival and alleviates symptomatology in murine models of Huntington's disease.Laquinimod dampens hyperactive cytokine production in Huntington's disease patient myeloid cells.αB-Crystallin overexpression in astrocytes modulates the phenotype of the BACHD mouse model of Huntington's disease A small molecule TrkB ligand reduces motor impairment and neuropathology in R6/2 and BACHD mouse models of Huntington's disease.RNA-Seq of Huntington's disease patient myeloid cells reveals innate transcriptional dysregulation associated with proinflammatory pathway activation.HTT-lowering reverses Huntington's disease immune dysfunction caused by NFκB pathway dysregulation.Peripheral inflammation in neurodegeneration.The role of the immune system in Huntington's disease.The role of cannabinoids and leptin in neurological diseases.Cannabinoids in Neurodegenerative Disorders and Stroke/Brain Trauma: From Preclinical Models to Clinical Applications.Huntington's Disease: Mechanisms of Pathogenesis and Therapeutic Strategies.Loss of the Sexually Dimorphic Neuro-Inflammatory Response in a Transgenic Mouse Model of Huntington's Disease.Mutant huntingtin is present in neuronal grafts in Huntington disease patients.Cerebrovascular and blood-brain barrier impairments in Huntington's disease: Potential implications for its pathophysiology.Anxious behavior induces elevated hippocampal Cb2 receptor gene expression.Cannabinoid CB2 Agonist GW405833 Suppresses Inflammatory and Neuropathic Pain through a CB1 Mechanism that is Independent of CB2 Receptors in Mice.NUB1 snubs huntingtin toxicity.In vivo neutralization of the protagonist role of macrophages during the chronic inflammatory stage of Huntington's disease

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Cannabinoid receptor 2 signaling in peripheral immune cells modulates disease onset and severity in mouse models of Huntington's disease.

http://www.wikidata.org/entity/Q37120339

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on December 2012

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Cannabinoid receptor 2 signali ...... odels of Huntington's disease.

@en

Cannabinoid receptor 2 signali ...... odels of Huntington's disease.

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type

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Cannabinoid receptor 2 signali ...... odels of Huntington's disease.

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Cannabinoid receptor 2 signali ...... odels of Huntington's disease.

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prefLabel

Cannabinoid receptor 2 signali ...... odels of Huntington's disease.

@en

Cannabinoid receptor 2 signali ...... odels of Huntington's disease.

@nl

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JNEUROSCI.4008-12.2012

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Journal of Neuroscience

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Cannabinoid receptor 2 signali ...... odels of Huntington's disease.

@en

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Diana Dunkelberger

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Jennifer Truong

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Jill Bouchard

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Kristofer Bouchard

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Nephi Stella

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Paul J Muchowski

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Saliha Moussaoui

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Sandrine Desrayaud

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P2860

Expression of central and peripheral cannabinoid receptors in human immune tissues and leukocyte subpopulations

The ageing systemic milieu negatively regulates neurogenesis and cognitive function.

CB2 receptor-mediated migration of immune cells: it can go either way

The CB2 cannabinoid agonist AM-1241 prolongs survival in a transgenic mouse model of amyotrophic lateral sclerosis when initiated at symptom onset

The cannabinoid CB2 receptor as a target for inflammation-dependent neurodegeneration

Reduction of human monocytic cell neurotoxicity and cytokine secretion by ligands of the cannabinoid-type CB2 receptor

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

Analyzing real-time PCR data by the comparative C(T) method

Identification and functional characterization of brainstem cannabinoid CB2 receptors

Molecular characterization of a peripheral receptor for cannabinoids

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18259-18268

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scholarly article

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10.1523/JNEUROSCI.4008-12.2012

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50

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32

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Sarah J. Tabrizi

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2012-12-01T00:00:00Z

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23238740

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Huntington disease

cannabinoid receptor

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3753072

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