IFNalpha kinoid vaccine-induced neutralizing antibodies prevent clinical manifestations in a lupus flare murine model
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Immune-regulatory mechanisms in systemic autoimmune and rheumatic diseasesType I interferon blockade in systemic lupus erythematosus: where do we stand?TLRs and interferons: a central paradigm in autoimmunityModelling clinical systemic lupus erythematosus: similarities, differences and success storiesEmerging therapies for systemic lupus erythematosus--focus on targeting interferon-alphaInterferon α kinoid induces neutralizing anti-interferon α antibodies that decrease the expression of interferon-induced and B cell activation associated transcripts: analysis of extended follow-up data from the interferon α kinoid phase I/II study.Distinct Functions of Autoantibodies Against Interferon in Systemic Lupus Erythematosus: A Comprehensive Analysis of Anticytokine Autoantibodies in Common Rheumatic DiseasesA genomic approach to human autoimmune diseases.Lupus nephritis: lessons from murine modelsActivation of type I interferon pathway in systemic lupus erythematosus: association with distinct clinical phenotypes.Active immunization to tumor necrosis factor-alpha is effective in treating chronic established inflammatory disease: a long-term study in a transgenic model of arthritis.Murine models of systemic lupus erythematosusThe tolerogenic peptide, hCDR1, down-regulates the expression of interferon-α in murine and human systemic lupus erythematosus.Interferon-inducible gene 202b controls CD8(+) T cell-mediated suppression in anti-DNA Ig peptide-treated (NZB × NZW) F1 lupus mice.Amine-reactive OVA multimers for auto-vaccination against cytokines and other mediators: perspectives illustrated for GCP-2 in L. major infection.The role of cytokines in the pathogenesis and treatment of systemic lupus erythematosusIFN-α and CD46 stimulation are associated with active lupus and skew natural T regulatory cell differentiation to type 1 regulatory T (Tr1) cellsPhenotypic and functional alterations of pDCs in lupus-prone mice.Sifalimumab, a human anti-interferon-α monoclonal antibody, in systemic lupus erythematosus: a phase I randomized, controlled, dose-escalation study.IFNα Inducible Models of Murine SLE.IL-1 Vaccination Is Suitable for Treating Inflammatory Diseases.Use of type I interferon-inducible mRNAs as pharmacodynamic markers and potential diagnostic markers in trials with sifalimumab, an anti-IFNα antibody, in systemic lupus erythematosus.Plasmacytoid dendritic cells in antiviral immunity and autoimmunity.Kinoids: a family of immunogens for active anticytokine immunotherapy applied to autoimmune diseases and cancer.Immunodrugs: breaking B- but not T-cell tolerance with therapeutic anticytokine vaccines.Aberrant B-lymphocyte responses in lupus: inherent or induced and potential therapeutic targets.Recent developments in the treatment of patients with systemic lupus erythematosus: focusing on biologic therapies.Type I IFNs as biomarkers in rheumatoid arthritis: towards disease profiling and personalized medicine.Targeting interferons in systemic lupus erythematosus: current and future prospects.Emerging therapies in systemic lupus erythematous: from clinical trial to the real life.Update on Biologic Therapies for Systemic Lupus Erythematosus.Down-regulation of interferon signature in systemic lupus erythematosus patients by active immunization with interferon α-kinoid.Humoral markers of active Epstein-Barr virus infection associate with anti-extractable nuclear antigen autoantibodies and plasma galectin-3 binding protein in systemic lupus erythematosus.JAK inhibitor has the amelioration effect in lupus-prone mice: the involvement of IFN signature gene downregulation.[Auto-vaccines: an immunological alternative to gene silencing].[Update on the use of active anti-cytokine therapies with kinoid vaccines for the treatment of inflammatory diseases].Incorporation of tetanus-epitope into virus-like particles achieves vaccine responses even in older recipients in models of psoriasis, Alzheimer's and cat allergy.Remission of systemic lupus erythematosus disease activity with regulatory cytokine interleukin (IL)-35 in Murphy Roths Large (MRL)/lpr mice.
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IFNalpha kinoid vaccine-induced neutralizing antibodies prevent clinical manifestations in a lupus flare murine model
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 11 March 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
IFNalpha kinoid vaccine-induce ...... in a lupus flare murine model
@en
IFNalpha kinoid vaccine-induce ...... in a lupus flare murine model.
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type
label
IFNalpha kinoid vaccine-induce ...... in a lupus flare murine model
@en
IFNalpha kinoid vaccine-induce ...... in a lupus flare murine model.
@nl
prefLabel
IFNalpha kinoid vaccine-induce ...... in a lupus flare murine model
@en
IFNalpha kinoid vaccine-induce ...... in a lupus flare murine model.
@nl
P2093
P2860
P50
P356
P1476
IFNalpha kinoid vaccine-induce ...... in a lupus flare murine model
@en
P2093
Alexis Mathian
Bernard Bizzini
Daniel Zagury
Dominique Emilie
Gabriel Peltre
Hélène Le Buanec
Patrick Larcier
Roger Burnett
Sophie Koutouzov
P2860
P304
P356
10.1073/PNAS.0900615106
P407
P577
2009-03-11T00:00:00Z