The glucagon-like peptide-1 receptor regulates endogenous glucose production and muscle glucose uptake independent of its incretin action.
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Physiology of proglucagon peptides: role of glucagon and GLP-1 in health and diseaseLiraglutide prevents microvascular insulin resistance and preserves muscle capillary density in high-fat diet-fed ratsGlucagon-like peptide 1 recruits muscle microvasculature and improves insulin's metabolic action in the presence of insulin resistanceGLP-1 at physiological concentrations recruits skeletal and cardiac muscle microvasculature in healthy humans.Protein kinase A mediates glucagon-like peptide 1-induced nitric oxide production and muscle microvascular recruitmentGlucagon-like peptide 1 recruits microvasculature and increases glucose use in muscle via a nitric oxide-dependent mechanismNeonatal exendin-4 treatment reduces oxidative stress and prevents hepatic insulin resistance in intrauterine growth-retarded rats.Glucagon-like peptide-1 receptor knockout mice are protected from high-fat diet-induced insulin resistanceGlucagon like peptide-1-induced glucose metabolism in differentiated human muscle satellite cells is attenuated by hyperglycemiaGlucagon receptor knockout prevents insulin-deficient type 1 diabetes in miceKnock-in mice for the R50X mutation in the PYGM gene present with McArdle disease.Effects on glucagon-like peptide-1 secretion by distal ileal administration of nutrients.Mechanisms underlying weight loss and metabolic improvements in rodent models of bariatric surgery.GLP-1 based therapeutics: simultaneously combating T2DM and obesity.Remodeling of hepatic metabolism and hyperaminoacidemia in mice deficient in proglucagon-derived peptides.Lipoprotein effects of incretin analogs and dipeptidyl peptidase 4 inhibitorsChronic administration of the glucagon-like peptide-1 analog, liraglutide, delays the onset of diabetes and lowers triglycerides in UCD-T2DM rats.Ileal Interposition in Rats with Experimental Type 2 Like Diabetes Improves Glycemic Control Independently of Glucose Absorption.Glp-1 analog, liraglutide, ameliorates hepatic steatosis and cardiac hypertrophy in C57BL/6J mice fed a Western diet.Brain GLP-1 and insulin sensitivity.The incretin hormone glucagon-like peptide 1 increases mitral cell excitability by decreasing conductance of a voltage-dependent potassium channel.The GLP-1 receptor agonists exenatide and liraglutide activate Glucose transport by an AMPK-dependent mechanism.NIH experiment in centralized mouse phenotyping: the Vanderbilt experience and recommendations for evaluating glucose homeostasis in the mouse.Efficacy of increased resistant starch consumption in human type 2 diabetes.Gut-liver interaction in triglyceride-rich lipoprotein metabolism.Use of the dipeptidyl peptidase-4 inhibitor linagliptin in combination therapy for type 2 diabetes.Effects of Roux-en-Y gastric bypass on energy and glucose homeostasis are preserved in two mouse models of functional glucagon-like peptide-1 deficiency.C/EBP homologous protein modulates liraglutide-mediated attenuation of non-alcoholic steatohepatitis.Glucose-dependent insulinotropic polypeptide directly induces glucose transport in rat skeletal muscle.Direct effect of incretin hormones on glucose and glycerol metabolism and hemodynamics.Colesevelam suppresses hepatic glycogenolysis by TGR5-mediated induction of GLP-1 action in DIO mice.Neuroendocrine mechanisms underlying bariatric surgery - insights from human studies and animal models.Leptin recruits Creb-regulated transcriptional coactivator 1 to improve hyperglycemia in insulin-deficient diabetesRegulation of glucose kinetics during exercise by the glucagon-like peptide-1 receptor.Hyperinsulinemic-euglycemic clamps in conscious, unrestrained mice.Effects of exercise interventions in graft-versus-host disease models.Direct effect of GLP-1 infusion on endogenous glucose production in humans.Muscle molecular adaptations to endurance exercise training are conditioned by glycogen availability: a proteomics-based analysis in the McArdle mouse model.Maternal Exercise Improves Glucose Tolerance in Female Offspring.Skeletal muscle overexpression of nicotinamide phosphoribosyl transferase in mice coupled with voluntary exercise augments exercise endurance.
P2860
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P2860
The glucagon-like peptide-1 receptor regulates endogenous glucose production and muscle glucose uptake independent of its incretin action.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh
2008年學術文章
@zh-hant
name
The glucagon-like peptide-1 re ...... endent of its incretin action.
@en
The glucagon-like peptide-1 re ...... endent of its incretin action.
@nl
type
label
The glucagon-like peptide-1 re ...... endent of its incretin action.
@en
The glucagon-like peptide-1 re ...... endent of its incretin action.
@nl
prefLabel
The glucagon-like peptide-1 re ...... endent of its incretin action.
@en
The glucagon-like peptide-1 re ...... endent of its incretin action.
@nl
P2093
P2860
P356
P1433
P1476
The glucagon-like peptide-1 re ...... endent of its incretin action.
@en
P2093
Brianna M Julien
David H Wasserman
Deanna P Bracy
Freyja D James
Julio E Ayala
P2860
P304
P356
10.1210/EN.2008-0945
P407
P577
2008-11-13T00:00:00Z