Genetic and pharmacologic inhibition of mitochondrial-dependent necrosis attenuates muscular dystrophy. - Wikidata - awgldk - TriplyDB

Genetic and pharmacologic inhibition of mitochondrial-dependent necrosis attenuates muscular dystrophy.

Genetic and pharmacologic inhibition of mitochondrial-dependent necrosis attenuates muscular dystrophy.

http://www.wikidata.org/entity/Q37127322

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Inhibition of the Mitochondrial Permeability Transition for Cytoprotection: Direct versus Indirect Mechanisms Antamanide, a derivative of Amanita phalloides, is a novel inhibitor of the mitochondrial permeability transition pore Skeletal muscle laminin and MDC1A: pathogenesis and treatment strategies.Volitional weight-lifting in rats promotes adaptation via performance and muscle morphology prior to gains in muscle mass Cyclophilin D controls mitochondrial pore-dependent Ca(2+) exchange, metabolic flexibility, and propensity for heart failure in mice.Investigation of Debio 025, a cyclophilin inhibitor, in the dystrophic mdx mouse, a model for Duchenne muscular dystrophy Molecular mechanisms that differentiate apoptosis from programmed necrosis Regulated necrotic cell death: the passive aggressive side of Bax and Bak Remodeling of Mitochondrial Flashes in Muscular Development and Dystrophy in Zebrafish Photo-induction and automated quantification of reversible mitochondrial permeability transition pore opening in primary mouse myotubes Current understanding of molecular pathology and treatment of cardiomyopathy in duchenne muscular dystrophy Genetic evidence in the mouse solidifies the calcium hypothesis of myofiber death in muscular dystrophy Adenosine A(3) receptor stimulation induces protection of skeletal muscle from eccentric exercise-mediated injury A method for the direct identification of differentiating muscle cells by a fluorescent mitochondrial dye Modulation of F0F1-ATP synthase activity by cyclophilin D regulates matrix adenine nucleotide levels Severe osteogenesis imperfecta in cyclophilin B-deficient mice Apoptosis repressor with a CARD domain (ARC) restrains Bax-mediated pathogenesis in dystrophic skeletal muscle MG53 nucleates assembly of cell membrane repair machinery.A micropeptide encoded by a putative long noncoding RNA regulates muscle performance Phosphate is essential for inhibition of the mitochondrial permeability transition pore by cyclosporin A and by cyclophilin D ablation Enhancing muscle membrane repair by gene delivery of MG53 ameliorates muscular dystrophy and heart failure in δ-Sarcoglycan-deficient hamsters.Reduced IGF signaling prevents muscle cell death in a Caenorhabditis elegans model of muscular dystrophy Blockade of ActRIIB signaling triggers muscle fatigability and metabolic myopathy.Potent pro-inflammatory and pro-fibrotic molecules, osteopontin and galectin-3, are not major disease modulators of laminin α2 chain-deficient muscular dystrophy.CRISPR-Cpf1 correction of muscular dystrophy mutations in human cardiomyocytes and mice.Dystrophic Cardiomyopathy-Potential Role of Calcium in Pathogenesis, Treatment and Novel Therapies Ca2+ overload and mitochondrial permeability transition pore activation in living delta-sarcoglycan-deficient cardiomyocytes.Activating HSP72 in rodent skeletal muscle increases mitochondrial number and oxidative capacity and decreases insulin resistance.Enhanced Ca²⁺ influx from STIM1-Orai1 induces muscle pathology in mouse models of muscular dystrophy.Zebrafish models of collagen VI-related myopathies Identifying the components of the elusive mitochondrial permeability transition pore.TNF-induced necroptosis and PARP-1-mediated necrosis represent distinct routes to programmed necrotic cell death Pharmacologic management of Duchenne muscular dystrophy: target identification and preclinical trials Cyclophilin D-sensitive mitochondrial permeability transition in adult human brain and liver mitochondria.The collagen VI-related myopathies Ullrich congenital muscular dystrophy and Bethlem myopathy.Two close, too close: sarcoplasmic reticulum-mitochondrial crosstalk and cardiomyocyte fate Monoamine oxidase inhibition prevents mitochondrial dysfunction and apoptosis in myoblasts from patients with collagen VI myopathies.P38α MAPK underlies muscular dystrophy and myofiber death through a Bax-dependent mechanism.Debio-025 is more effective than prednisone in reducing muscular pathology in mdx mice.Mitochondrial dysfunction and defective autophagy in the pathogenesis of collagen VI muscular dystrophies.

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Genetic and pharmacologic inhibition of mitochondrial-dependent necrosis attenuates muscular dystrophy.

http://www.wikidata.org/entity/Q37127322

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 16 March 2008

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Genetic and pharmacologic inhi ...... attenuates muscular dystrophy.

@en

Genetic and pharmacologic inhi ...... attenuates muscular dystrophy.

@nl

type

label

Genetic and pharmacologic inhi ...... attenuates muscular dystrophy.

@en

Genetic and pharmacologic inhi ...... attenuates muscular dystrophy.

@nl

prefLabel

Genetic and pharmacologic inhi ...... attenuates muscular dystrophy.

@en

Genetic and pharmacologic inhi ...... attenuates muscular dystrophy.

@nl

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Nature Medicine

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Genetic and pharmacologic inhi ...... attenuates muscular dystrophy.

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Christopher P Baines

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Douglas P Millay

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Elisabeth R Barton

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Grégoire Vuagniaux

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H Lee Sweeney

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Hanna Osinska

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Jeffrey Robbins

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Michelle A Sargent

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P2860

Viral mediated expression of insulin-like growth factor I blocks the aging-related loss of skeletal muscle function

Defective membrane repair in dysferlin-deficient muscular dystrophy

Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death

Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death

Cyclophilin D is a component of mitochondrial permeability transition and mediates neuronal cell death after focal cerebral ischemia

The nonimmunosuppressive cyclosporin analogs NIM811 and UNIL025 display nanomolar potencies on permeability transition in brain-derived mitochondria.

The mitochondrion in apoptosis: how Pandora's box opens.

The dystrophin glycoprotein complex: signaling strength and integrity for the sarcolemma.

Properties of the permeability transition pore in mitochondria devoid of Cyclophilin D.

Muscular dystrophies involving the dystrophin-glycoprotein complex: an overview of current mouse models.

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442-447

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scholarly article

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10.1038/NM1736

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4

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14

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Jeffery D. Molkentin

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2008-03-16T00:00:00Z

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5507331

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18345011

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2655270

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