Distinct roles for mammalian target of rapamycin complexes in the fibroblast response to transforming growth factor-beta
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Autophagy in idiopathic pulmonary fibrosisThe Complexity of Targeting PI3K-Akt-mTOR Signalling in Human Acute Myeloid Leukaemia: The Importance of Leukemic Cell Heterogeneity, Neighbouring Mesenchymal Stem Cells and Immunocompetent CellsClinical Advancements in the Targeted Therapies against Liver Fibrosis.Noncanonical TGF-beta pathways, mTORC1 and Abl, in renal interstitial fibrogenesisType II transforming growth factor-beta receptor recycling is dependent upon the clathrin adaptor protein Dab2Delayed mTOR inhibition with low dose of everolimus reduces TGFβ expression, attenuates proteinuria and renal damage in the renal mass reduction modelNon-Smad transforming growth factor-β signaling regulated by focal adhesion kinase binding the p85 subunit of phosphatidylinositol 3-kinase.ERBB receptor activation is required for profibrotic responses to transforming growth factor beta.Sorting nexin 9 differentiates ligand-activated Smad3 from Smad2 for nuclear import and transforming growth factor β signaling.The insulin response integrates increased TGF-β signaling through Akt-induced enhancement of cell surface delivery of TGF-β receptors.Molecular biological characteristics of the recruitment of hematopoietic stem cells from bone marrow niche in chronic myeloid leukemia.Ras family small GTPase-mediated neuroprotective signaling in stroke.Retromer maintains basolateral distribution of the type II TGF-β receptor via the recycling endosome.Calpain-2 activates Akt via TGF-β1-mTORC2 pathway in pulmonary artery smooth muscle cellsProfibrotic TGFβ responses require the cooperative action of PDGF and ErbB receptor tyrosine kinases.TGF-β1 stimulates mitochondrial oxidative phosphorylation and generation of reactive oxygen species in cultured mouse podocytes, mediated in part by the mTOR pathway.TGF-β/Smad3 activates mammalian target of rapamycin complex-1 to promote collagen production by increasing HIF-1α expression.Activation of mTOR (mechanistic target of rapamycin) in rheumatic diseases.Transforming growth factor-β signaling participates in the maintenance of the primordial follicle pool in the mouse ovaryTransforming growth factor-β regulates the growth of valve interstitial cells in vitro.Roles of mTOR complexes in the kidney: implications for renal disease and transplantation.Everolimus is a potent inhibitor of activated hepatic stellate cell functions in vitro and in vivo, while demonstrating anti-angiogenic activities.Cell-penetrating peptides selectively targeting SMAD3 inhibit profibrotic TGF-β signaling.TGFbeta versatility: PI3K as a critical mediator of distinct cell type and context specific responses.Everolimus immunosuppression reduces the serum expression of fibrosis markers in liver transplant recipients.From TOR and SMAD, why HIF-1α can be bad.Profibrotic up-regulation of glucose transporter 1 by TGF-β involves activation of MEK and mammalian target of rapamycin complex 2 pathways.Impaired immunomodulatory function of chronic myeloid leukemia cancer stem cells and the possible mechanism involved in it.The Tension Biology of Wound Healing.Basolateral delivery of the type I transforming growth factor beta receptor is mediated by a dominant-acting cytoplasmic motif.Review: Metabolic Control of Immune System Activation in Rheumatic Diseases.TSC1 and TSC2 regulate cilia length and canonical Hedgehog signaling via different mechanisms.Activation of AMPK inhibits TGF-β1-induced airway smooth muscle cells proliferation and its potential mechanisms.Fatty acid synthase is required for profibrotic TGF-β signaling.The Role of the Mammalian Target of Rapamycin (mTOR) in Pulmonary Fibrosis.BCR/ABL oncogene-induced PI3K signaling pathway leads to chronic myeloid leukemia pathogenesis by impairing immuno-modulatory function of hemangioblasts.TGF-β stimulates biglycan core protein synthesis but not glycosaminoglycan chain elongation via Akt phosphorylation in vascular smooth muscle.
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Distinct roles for mammalian target of rapamycin complexes in the fibroblast response to transforming growth factor-beta
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on January 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Distinct roles for mammalian t ...... ransforming growth factor-beta
@en
Distinct roles for mammalian t ...... ansforming growth factor-beta.
@nl
type
label
Distinct roles for mammalian t ...... ransforming growth factor-beta
@en
Distinct roles for mammalian t ...... ansforming growth factor-beta.
@nl
prefLabel
Distinct roles for mammalian t ...... ransforming growth factor-beta
@en
Distinct roles for mammalian t ...... ansforming growth factor-beta.
@nl
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P2860
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Distinct roles for mammalian t ...... ransforming growth factor-beta
@en
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Edward B Leof
John Blenis
Mahefatiana Andrianifahanana
Mark C Wilkes
Maryanne Edens
Rod A Rahimi
Theodore J Kottom
P2860
P356
10.1158/0008-5472.CAN-08-2146
P407
P577
2009-01-01T00:00:00Z