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Spotlight on Antimicrobial Metabolites from the Marine Bacteria Pseudoalteromonas: Chemodiversity and Ecological SignificanceDiscovery Strategies of Bioactive Compounds Synthesized by Nonribosomal Peptide Synthetases and Type-I Polyketide Synthases Derived from Marine Microbiomes.Primer on agar-based microbial imaging mass spectrometryLessons learned from the transformation of natural product discovery to a genome-driven endeavorDiscovery of defense- and neuropeptides in social ants by genome-miningThe insect pathogen Serratia marcescens Db10 uses a hybrid non-ribosomal peptide synthetase-polyketide synthase to produce the antibiotic althiomycinAccumulation of a bioactive benzoisochromanequinone compound kalafungin by a wild type antitumor-medermycin-producing streptomycete strainAntibiotics for emerging pathogensThe chemical arsenal of Burkholderia pseudomallei is essential for pathogenicity.Two induced fungal polyketide pathways converge into antiproliferative spiroanthrones.Marine natural products: a new wave of drugs?Insights into secondary metabolism from a global analysis of prokaryotic biosynthetic gene clustersHistorical variation of structural novelty in a natural product library.Natural products version 2.0: connecting genes to molecules.Structural mass spectrometry: rapid methods for separation and analysis of peptide natural productseSNaPD: a versatile, web-based bioinformatics platform for surveying and mining natural product biosynthetic diversity from metagenomes.Antibiotics and bacterial resistance in the 21st century.Lantibiotics from Geobacillus thermodenitrificans.Nucleophilic 1,4-additions for natural product discovery.Structure determination and interception of biosynthetic intermediates for the plantazolicin class of highly discriminating antibiotics.The natural product domain seeker NaPDoS: a phylogeny based bioinformatic tool to classify secondary metabolite gene diversityAntibiotics and the gut microbiota.Enzymatic processing of fumiquinazoline F: a tandem oxidative-acylation strategy for the generation of multicyclic scaffolds in fungal indole alkaloid biosynthesis.Structure and mechanism of enzymes involved in biosynthesis and breakdown of the phosphonates fosfomycin, dehydrophos, and phosphinothricin.Practical 4'-phosphopantetheine active site discovery from proteomic samples.Finding novel pharmaceuticals in the systems biology era using multiple effective drug targets, phenotypic screening and knowledge of transporters: where drug discovery went wrong and how to fix it.Genomic basis for natural product biosynthetic diversity in the actinomycetesA sea of biosynthesis: marine natural products meet the molecular age.Statistical research on the bioactivity of new marine natural products discovered during the 28 years from 1985 to 2012.Atlas for drug discovery.Beta-glucuronidase as a sensitive and versatile reporter in actinomycetes.Identification of cryptic products of the gliotoxin gene cluster using NMR-based comparative metabolomics and a model for gliotoxin biosynthesisFunctional Characterization of a Ketoreductase-Encoding Gene med-ORF12 Involved in the Formation of a Stereospecific Pyran Ring during the Biosynthesis of an Antitumor Antibiotic Medermycin.Discovery of phosphonic acid natural products by mining the genomes of 10,000 actinomycetes.Native promoter strategy for high-yielding synthesis and engineering of fungal secondary metabolites.Draft Genome Sequence of Streptomyces sp. TP-A0356, a Producer of Yatakemycin.Structure elucidation and biosynthesis of fuscachelins, peptide siderophores from the moderate thermophile Thermobifida fusca.2-Alkyl-4-hydroxymethylfuran-3-carboxylic acids, antibiotic production inducers discovered by Streptomyces coelicolor genome mining."Cre/loxP plus BAC": a strategy for direct cloning of large DNA fragment and its applications in Photorhabdus luminescens and Agrobacterium tumefaciens.Homologous NRPS-like gene clusters mediate redundant small-molecule biosynthesis in Aspergillus flavus.
P2860
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P2860
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 05 April 2008
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Genome mining for novel natural product discovery.
@en
Genome mining for novel natural product discovery.
@nl
type
label
Genome mining for novel natural product discovery.
@en
Genome mining for novel natural product discovery.
@nl
prefLabel
Genome mining for novel natural product discovery.
@en
Genome mining for novel natural product discovery.
@nl
P356
P1476
Genome mining for novel natural product discovery.
@en
P304
P356
10.1021/JM700948Z
P407
P577
2008-04-05T00:00:00Z