Prelamin A causes progeria through cell-extrinsic mechanisms and prevents cancer invasion.
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Hallmarks of progeroid syndromes: lessons from mice and reprogrammed cellsMolecular insights into the premature aging disease progeriaPotential therapeutic effects of the MTOR inhibitors for preventing ageing and progeria-related disordersA Novel Role of Lamins from Genetic Disease to Cancer BiomarkersTransformation resistance in a premature aging disorder identifies a tumor-protective function of BRD4.DNA repair defects and genome instability in Hutchinson-Gilford Progeria Syndrome.A Screen for Epigenetically Silenced microRNA Genes in Gastrointestinal Stromal Tumors.Loss of MT1-MMP causes cell senescence and nuclear defects which can be reversed by retinoic acidProliferation of progeria cells is enhanced by lamina-associated polypeptide 2α (LAP2α) through expression of extracellular matrix proteinsNuclear lamins in cancerGDF11 administration does not extend lifespan in a mouse model of premature aging.Diverse lamin-dependent mechanisms interact to control chromatin dynamics. Focus on laminopathiesLamins at the crossroads of mechanosignalingMechanosensing by the nucleus: From pathways to scaling relationships.Rare progerin-expressing preadipocytes and adipocytes contribute to tissue depletion over timeProtein sequestration at the nuclear periphery as a potential regulatory mechanism in premature aging.Shared molecular and cellular mechanisms of premature ageing and ageing-associated diseases.Nucleoplasmic lamins define growth-regulating functions of lamina-associated polypeptide 2α in progeria cells.Cancer Susceptibility Models in Protease-Deficient Mice.Mice with reduced expression of the telomere-associated protein Ft1 develop p53-sensitive progeroid traits.Progerin phosphorylation in interphase is lower and less mechanosensitive than lamin-A,C in iPS-derived mesenchymal stem cells.
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P2860
Prelamin A causes progeria through cell-extrinsic mechanisms and prevents cancer invasion.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on January 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Prelamin A causes progeria thr ...... and prevents cancer invasion.
@en
Prelamin A causes progeria thr ...... and prevents cancer invasion.
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type
label
Prelamin A causes progeria thr ...... and prevents cancer invasion.
@en
Prelamin A causes progeria thr ...... and prevents cancer invasion.
@nl
prefLabel
Prelamin A causes progeria thr ...... and prevents cancer invasion.
@en
Prelamin A causes progeria thr ...... and prevents cancer invasion.
@nl
P2093
P2860
P50
P356
P1476
Prelamin A causes progeria through cell-extrinsic mechanisms and prevents cancer invasion
@en
P2093
Alejandro P Ugalde
Fernando G Osorio
Haydn M Prosser
M Soledad Fernández-García
Mario F Fraga
Roland Rad
Rubén Cabanillas
Víctor Fanjul
P2860
P2888
P356
10.1038/NCOMMS3268
P407
P577
2013-01-01T00:00:00Z